Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei
Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A (1) and B (2) are two...
| Publicado: |
2001
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v64_n6_p732_Maier http://hdl.handle.net/20.500.12110/paper_01633864_v64_n6_p732_Maier |
| Aporte de: |
| id |
paper:paper_01633864_v64_n6_p732_Maier |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_01633864_v64_n6_p732_Maier2023-06-08T15:14:14Z Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei antivirus agent liouvilloside A liouvilloside B triterpene derivative unclassified drug antiviral activity article cytostasis cytotoxicity drug isolation echinoderm Herpes simplex virus 1 immunomodulation structure analysis sulfation Animals Antineoplastic Agents Antiviral Agents Carbohydrate Conformation Cercopithecus aethiops Drug Screening Assays, Antitumor Herpesvirus 1, Human Hydrolysis Magnetic Resonance Spectroscopy Methylation Microbial Sensitivity Tests Oligosaccharides Sea Cucumbers Spectrometry, Mass, Fast Atom Bombardment Triterpenes Vero Cells Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A (1) and B (2) are two new examples of a small number of trisulfated triterpene glycosides from sea cucumbers belonging to the family Cucumariidae. Both glycosides were found to be virucidal against herpes simplex virus type 1 (HSV-1) at concentrations below 10 μg/mL. 2001 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v64_n6_p732_Maier http://hdl.handle.net/20.500.12110/paper_01633864_v64_n6_p732_Maier |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
antivirus agent liouvilloside A liouvilloside B triterpene derivative unclassified drug antiviral activity article cytostasis cytotoxicity drug isolation echinoderm Herpes simplex virus 1 immunomodulation structure analysis sulfation Animals Antineoplastic Agents Antiviral Agents Carbohydrate Conformation Cercopithecus aethiops Drug Screening Assays, Antitumor Herpesvirus 1, Human Hydrolysis Magnetic Resonance Spectroscopy Methylation Microbial Sensitivity Tests Oligosaccharides Sea Cucumbers Spectrometry, Mass, Fast Atom Bombardment Triterpenes Vero Cells |
| spellingShingle |
antivirus agent liouvilloside A liouvilloside B triterpene derivative unclassified drug antiviral activity article cytostasis cytotoxicity drug isolation echinoderm Herpes simplex virus 1 immunomodulation structure analysis sulfation Animals Antineoplastic Agents Antiviral Agents Carbohydrate Conformation Cercopithecus aethiops Drug Screening Assays, Antitumor Herpesvirus 1, Human Hydrolysis Magnetic Resonance Spectroscopy Methylation Microbial Sensitivity Tests Oligosaccharides Sea Cucumbers Spectrometry, Mass, Fast Atom Bombardment Triterpenes Vero Cells Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei |
| topic_facet |
antivirus agent liouvilloside A liouvilloside B triterpene derivative unclassified drug antiviral activity article cytostasis cytotoxicity drug isolation echinoderm Herpes simplex virus 1 immunomodulation structure analysis sulfation Animals Antineoplastic Agents Antiviral Agents Carbohydrate Conformation Cercopithecus aethiops Drug Screening Assays, Antitumor Herpesvirus 1, Human Hydrolysis Magnetic Resonance Spectroscopy Methylation Microbial Sensitivity Tests Oligosaccharides Sea Cucumbers Spectrometry, Mass, Fast Atom Bombardment Triterpenes Vero Cells |
| description |
Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A (1) and B (2) are two new examples of a small number of trisulfated triterpene glycosides from sea cucumbers belonging to the family Cucumariidae. Both glycosides were found to be virucidal against herpes simplex virus type 1 (HSV-1) at concentrations below 10 μg/mL. |
| title |
Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei |
| title_short |
Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei |
| title_full |
Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei |
| title_fullStr |
Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei |
| title_full_unstemmed |
Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei |
| title_sort |
two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber staurocucumis liouvillei |
| publishDate |
2001 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v64_n6_p732_Maier http://hdl.handle.net/20.500.12110/paper_01633864_v64_n6_p732_Maier |
| _version_ |
1768541933157744640 |