New sulfated polyhydroxysteroids from the Antarctic ophiuroid Astrotoma agassizii

Three new and two known sulfated steroidal polyols have been isolated from the Antarctic ophiuroid Astrotoma agassizii. All of the new steroids possess a terminal isopropenyl group and a C-21 sulfoxy moiety in the side chain but differ in the steroidal nuclei. The structures of these new steroids we...

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Autores principales:	Roccatagliata, Alejandro Jorge, Maier, Marta Silvia, Seldes, Alicia Marta
Publicado:	1998
Materias:	5alpha cholest 24 ene 2beta,3alpha,21 triol 3,21 disulfate cholesta 5,24 diene 2alpha,3alpha,4beta,21 tetrol 3,21 disulfate cholesta 5,24 diene 2beta,3alpha,21 triol 2,21 disulfate cholesterol hydroxysteroid sterol unclassified drug article chemical analysis column chromatography data analysis drug isolation enzyme activity high performance liquid chromatography nuclear magnetic resonance sulfation Astrotoma agassizii
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v61_n3_p370_Roccatagliata http://hdl.handle.net/20.500.12110/paper_01633864_v61_n3_p370_Roccatagliata
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01633864_v61_n3_p370_Roccatagliata
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spelling	paper:paper_01633864_v61_n3_p370_Roccatagliata2023-06-08T15:14:11Z New sulfated polyhydroxysteroids from the Antarctic ophiuroid Astrotoma agassizii Roccatagliata, Alejandro Jorge Maier, Marta Silvia Seldes, Alicia Marta 5alpha cholest 24 ene 2beta,3alpha,21 triol 3,21 disulfate cholesta 5,24 diene 2alpha,3alpha,4beta,21 tetrol 3,21 disulfate cholesta 5,24 diene 2beta,3alpha,21 triol 2,21 disulfate cholesterol hydroxysteroid sterol unclassified drug article chemical analysis column chromatography data analysis drug isolation enzyme activity high performance liquid chromatography nuclear magnetic resonance sulfation Astrotoma agassizii Three new and two known sulfated steroidal polyols have been isolated from the Antarctic ophiuroid Astrotoma agassizii. All of the new steroids possess a terminal isopropenyl group and a C-21 sulfoxy moiety in the side chain but differ in the steroidal nuclei. The structures of these new steroids were established from spectral and chemical correlations with related steroids as (20R)-cholesta-5,24-diene-2β,3α,21-triol 2,21-disulfate (1), (20R)-5α-cholest-24-ene-2β,3α,21-triol 3,21-disulfate (3), and (20R)- cholesta-5,24-diene-2α,3α,4β,21-tetrol 3,21-disulfate (5). Analysis of the nonsulfated sterol fraction has shown the presence of cholest-5-en-3β-ol, cholesta-5,24-dien-3β-ol and (22E) cholesta-5,22-dien-3β-ol as the major sterols. Fil:Roccatagliata, A.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Maier, M.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Seldes, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1998 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v61_n3_p370_Roccatagliata http://hdl.handle.net/20.500.12110/paper_01633864_v61_n3_p370_Roccatagliata
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	5alpha cholest 24 ene 2beta,3alpha,21 triol 3,21 disulfate cholesta 5,24 diene 2alpha,3alpha,4beta,21 tetrol 3,21 disulfate cholesta 5,24 diene 2beta,3alpha,21 triol 2,21 disulfate cholesterol hydroxysteroid sterol unclassified drug article chemical analysis column chromatography data analysis drug isolation enzyme activity high performance liquid chromatography nuclear magnetic resonance sulfation Astrotoma agassizii
spellingShingle	5alpha cholest 24 ene 2beta,3alpha,21 triol 3,21 disulfate cholesta 5,24 diene 2alpha,3alpha,4beta,21 tetrol 3,21 disulfate cholesta 5,24 diene 2beta,3alpha,21 triol 2,21 disulfate cholesterol hydroxysteroid sterol unclassified drug article chemical analysis column chromatography data analysis drug isolation enzyme activity high performance liquid chromatography nuclear magnetic resonance sulfation Astrotoma agassizii Roccatagliata, Alejandro Jorge Maier, Marta Silvia Seldes, Alicia Marta New sulfated polyhydroxysteroids from the Antarctic ophiuroid Astrotoma agassizii
topic_facet	5alpha cholest 24 ene 2beta,3alpha,21 triol 3,21 disulfate cholesta 5,24 diene 2alpha,3alpha,4beta,21 tetrol 3,21 disulfate cholesta 5,24 diene 2beta,3alpha,21 triol 2,21 disulfate cholesterol hydroxysteroid sterol unclassified drug article chemical analysis column chromatography data analysis drug isolation enzyme activity high performance liquid chromatography nuclear magnetic resonance sulfation Astrotoma agassizii
description	Three new and two known sulfated steroidal polyols have been isolated from the Antarctic ophiuroid Astrotoma agassizii. All of the new steroids possess a terminal isopropenyl group and a C-21 sulfoxy moiety in the side chain but differ in the steroidal nuclei. The structures of these new steroids were established from spectral and chemical correlations with related steroids as (20R)-cholesta-5,24-diene-2β,3α,21-triol 2,21-disulfate (1), (20R)-5α-cholest-24-ene-2β,3α,21-triol 3,21-disulfate (3), and (20R)- cholesta-5,24-diene-2α,3α,4β,21-tetrol 3,21-disulfate (5). Analysis of the nonsulfated sterol fraction has shown the presence of cholest-5-en-3β-ol, cholesta-5,24-dien-3β-ol and (22E) cholesta-5,22-dien-3β-ol as the major sterols.
author	Roccatagliata, Alejandro Jorge Maier, Marta Silvia Seldes, Alicia Marta
author_facet	Roccatagliata, Alejandro Jorge Maier, Marta Silvia Seldes, Alicia Marta
author_sort	Roccatagliata, Alejandro Jorge
title	New sulfated polyhydroxysteroids from the Antarctic ophiuroid Astrotoma agassizii
title_short	New sulfated polyhydroxysteroids from the Antarctic ophiuroid Astrotoma agassizii
title_full	New sulfated polyhydroxysteroids from the Antarctic ophiuroid Astrotoma agassizii
title_fullStr	New sulfated polyhydroxysteroids from the Antarctic ophiuroid Astrotoma agassizii
title_full_unstemmed	New sulfated polyhydroxysteroids from the Antarctic ophiuroid Astrotoma agassizii
title_sort	new sulfated polyhydroxysteroids from the antarctic ophiuroid astrotoma agassizii
publishDate	1998
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v61_n3_p370_Roccatagliata http://hdl.handle.net/20.500.12110/paper_01633864_v61_n3_p370_Roccatagliata
work_keys_str_mv	AT roccatagliataalejandrojorge newsulfatedpolyhydroxysteroidsfromtheantarcticophiuroidastrotomaagassizii AT maiermartasilvia newsulfatedpolyhydroxysteroidsfromtheantarcticophiuroidastrotomaagassizii AT seldesaliciamarta newsulfatedpolyhydroxysteroidsfromtheantarcticophiuroidastrotomaagassizii
_version_	1768543652729061376

New sulfated polyhydroxysteroids from the Antarctic ophiuroid Astrotoma agassizii

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