16-hydroxylated withanolides from Exodeconus maritimus

In addition to the known compounds withanolide A (4), withanone (5), and NIC-3 (6), three 16-hydroxylated withanolides were isolated from Exodeconus maritimus. The new withanolides were identified as 6α,7α-epoxy-5α,16β- dihydroxy-1-oxowitha-2,17(20),24-trienolide (exodeconolide A, 1), 6α,7α- epoxy-5...

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Autores principales:	Veleiro, Adriana Silvia, Burton, Gerardo
Publicado:	1997
Materias:	exodeconolide a exodeconolide b exodeconolide c nic 3 unclassified drug withanolide withanolide a withanone antiinflammatory activity antimicrobial activity antineoplastic activity article defense mechanism drug isolation drug structure immunomodulation mass spectrometry nuclear magnetic resonance phytochemistry species differentiation structure activity relation taxonomy Exodeconus maritimus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v60_n6_p568_Gil http://hdl.handle.net/20.500.12110/paper_01633864_v60_n6_p568_Gil
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01633864_v60_n6_p568_Gil
record_format	dspace
spelling	paper:paper_01633864_v60_n6_p568_Gil2023-06-08T15:14:10Z 16-hydroxylated withanolides from Exodeconus maritimus Veleiro, Adriana Silvia Burton, Gerardo exodeconolide a exodeconolide b exodeconolide c nic 3 unclassified drug withanolide withanolide a withanone antiinflammatory activity antimicrobial activity antineoplastic activity article defense mechanism drug isolation drug structure immunomodulation mass spectrometry nuclear magnetic resonance phytochemistry species differentiation structure activity relation taxonomy Exodeconus maritimus In addition to the known compounds withanolide A (4), withanone (5), and NIC-3 (6), three 16-hydroxylated withanolides were isolated from Exodeconus maritimus. The new withanolides were identified as 6α,7α-epoxy-5α,16β- dihydroxy-1-oxowitha-2,17(20),24-trienolide (exodeconolide A, 1), 6α,7α- epoxy-5α,16α-dihydroxy-l-oxowitha-2,17(20),24-trienolide (exodeconolide B, 2), and 6α7α-epoxy-5α,16α,17α-trihydroxy-1-oxowitha-2, 24-dienolide (exodeconolide C, 3), by a combination of spectroscopic (1D and 2D NMR, MS) and chemical methods with the aid of molecular modeling. Fil:Veleiro, A.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1997 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v60_n6_p568_Gil http://hdl.handle.net/20.500.12110/paper_01633864_v60_n6_p568_Gil
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	exodeconolide a exodeconolide b exodeconolide c nic 3 unclassified drug withanolide withanolide a withanone antiinflammatory activity antimicrobial activity antineoplastic activity article defense mechanism drug isolation drug structure immunomodulation mass spectrometry nuclear magnetic resonance phytochemistry species differentiation structure activity relation taxonomy Exodeconus maritimus
spellingShingle	exodeconolide a exodeconolide b exodeconolide c nic 3 unclassified drug withanolide withanolide a withanone antiinflammatory activity antimicrobial activity antineoplastic activity article defense mechanism drug isolation drug structure immunomodulation mass spectrometry nuclear magnetic resonance phytochemistry species differentiation structure activity relation taxonomy Exodeconus maritimus Veleiro, Adriana Silvia Burton, Gerardo 16-hydroxylated withanolides from Exodeconus maritimus
topic_facet	exodeconolide a exodeconolide b exodeconolide c nic 3 unclassified drug withanolide withanolide a withanone antiinflammatory activity antimicrobial activity antineoplastic activity article defense mechanism drug isolation drug structure immunomodulation mass spectrometry nuclear magnetic resonance phytochemistry species differentiation structure activity relation taxonomy Exodeconus maritimus
description	In addition to the known compounds withanolide A (4), withanone (5), and NIC-3 (6), three 16-hydroxylated withanolides were isolated from Exodeconus maritimus. The new withanolides were identified as 6α,7α-epoxy-5α,16β- dihydroxy-1-oxowitha-2,17(20),24-trienolide (exodeconolide A, 1), 6α,7α- epoxy-5α,16α-dihydroxy-l-oxowitha-2,17(20),24-trienolide (exodeconolide B, 2), and 6α7α-epoxy-5α,16α,17α-trihydroxy-1-oxowitha-2, 24-dienolide (exodeconolide C, 3), by a combination of spectroscopic (1D and 2D NMR, MS) and chemical methods with the aid of molecular modeling.
author	Veleiro, Adriana Silvia Burton, Gerardo
author_facet	Veleiro, Adriana Silvia Burton, Gerardo
author_sort	Veleiro, Adriana Silvia
title	16-hydroxylated withanolides from Exodeconus maritimus
title_short	16-hydroxylated withanolides from Exodeconus maritimus
title_full	16-hydroxylated withanolides from Exodeconus maritimus
title_fullStr	16-hydroxylated withanolides from Exodeconus maritimus
title_full_unstemmed	16-hydroxylated withanolides from Exodeconus maritimus
title_sort	16-hydroxylated withanolides from exodeconus maritimus
publishDate	1997
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v60_n6_p568_Gil http://hdl.handle.net/20.500.12110/paper_01633864_v60_n6_p568_Gil
work_keys_str_mv	AT veleiroadrianasilvia 16hydroxylatedwithanolidesfromexodeconusmaritimus AT burtongerardo 16hydroxylatedwithanolidesfromexodeconusmaritimus
_version_	1768544952332058624

16-hydroxylated withanolides from Exodeconus maritimus

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