Ornithine decarboxylase activity and polyamine levels in the epididymis of prepubertal rat after antiandrogen administration
The antiandrogens flutamide and casodex have been administered subcutaneously (vehicle, 1, 5, or 10 mg per day) to prepubertal male rats for 10 days. A significant change of epididymal weight has been observed after both treatments, from the lowest dose used. Epididymal dihydrotestosterone concentra...
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1997
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01485016_v38_n2_p163_Rulli http://hdl.handle.net/20.500.12110/paper_01485016_v38_n2_p163_Rulli |
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paper:paper_01485016_v38_n2_p163_Rulli2023-06-08T15:13:10Z Ornithine decarboxylase activity and polyamine levels in the epididymis of prepubertal rat after antiandrogen administration casodex epididymis flutamide ornithine decarboxylase polyamines androgen androstanolone antiandrogen bicalutamide flutamide ornithine decarboxylase polyamine putrescine spermidine spermine article controlled study development drug effect enzyme activity epididymis male nonhuman polyamine metabolism prepuberty priority journal rat subcutaneous drug administration The antiandrogens flutamide and casodex have been administered subcutaneously (vehicle, 1, 5, or 10 mg per day) to prepubertal male rats for 10 days. A significant change of epididymal weight has been observed after both treatments, from the lowest dose used. Epididymal dihydrotestosterone concentrations were significantly increased in flutamide- or casodex-treated rats, while epididymal 3α-androstanediol concentrations were affected only after flutamide administration, suggesting a differential effect on androgen metabolism between both antiandrogens. Ornithine decarboxylase (ODC) activity was significantly decreased by flutamide, and to a lesser extent by casodex. Antiandrogen administration resulted in a significant decrease in epididymal content of the polyamines putrescine, spermidine, and spermine. A slight but significant decrease in putrescine and spermidine concentrations, but not in spermine, was observed after flutamide treatment. However, casodex had no effects on polyamines levels. A decrease in putrescine concentration was detected only when ODC activity fell to rather low levels. Interference of the antiandrogens with the biological action of androgens on ODC activity was clearly seen in immature male rats. Therefore, both epididymal growth and differentiation, in correlation to ODC activity, would be severely affected at an early period of sexual development, such as prepuberty. 1997 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01485016_v38_n2_p163_Rulli http://hdl.handle.net/20.500.12110/paper_01485016_v38_n2_p163_Rulli |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
casodex epididymis flutamide ornithine decarboxylase polyamines androgen androstanolone antiandrogen bicalutamide flutamide ornithine decarboxylase polyamine putrescine spermidine spermine article controlled study development drug effect enzyme activity epididymis male nonhuman polyamine metabolism prepuberty priority journal rat subcutaneous drug administration |
| spellingShingle |
casodex epididymis flutamide ornithine decarboxylase polyamines androgen androstanolone antiandrogen bicalutamide flutamide ornithine decarboxylase polyamine putrescine spermidine spermine article controlled study development drug effect enzyme activity epididymis male nonhuman polyamine metabolism prepuberty priority journal rat subcutaneous drug administration Ornithine decarboxylase activity and polyamine levels in the epididymis of prepubertal rat after antiandrogen administration |
| topic_facet |
casodex epididymis flutamide ornithine decarboxylase polyamines androgen androstanolone antiandrogen bicalutamide flutamide ornithine decarboxylase polyamine putrescine spermidine spermine article controlled study development drug effect enzyme activity epididymis male nonhuman polyamine metabolism prepuberty priority journal rat subcutaneous drug administration |
| description |
The antiandrogens flutamide and casodex have been administered subcutaneously (vehicle, 1, 5, or 10 mg per day) to prepubertal male rats for 10 days. A significant change of epididymal weight has been observed after both treatments, from the lowest dose used. Epididymal dihydrotestosterone concentrations were significantly increased in flutamide- or casodex-treated rats, while epididymal 3α-androstanediol concentrations were affected only after flutamide administration, suggesting a differential effect on androgen metabolism between both antiandrogens. Ornithine decarboxylase (ODC) activity was significantly decreased by flutamide, and to a lesser extent by casodex. Antiandrogen administration resulted in a significant decrease in epididymal content of the polyamines putrescine, spermidine, and spermine. A slight but significant decrease in putrescine and spermidine concentrations, but not in spermine, was observed after flutamide treatment. However, casodex had no effects on polyamines levels. A decrease in putrescine concentration was detected only when ODC activity fell to rather low levels. Interference of the antiandrogens with the biological action of androgens on ODC activity was clearly seen in immature male rats. Therefore, both epididymal growth and differentiation, in correlation to ODC activity, would be severely affected at an early period of sexual development, such as prepuberty. |
| title |
Ornithine decarboxylase activity and polyamine levels in the epididymis of prepubertal rat after antiandrogen administration |
| title_short |
Ornithine decarboxylase activity and polyamine levels in the epididymis of prepubertal rat after antiandrogen administration |
| title_full |
Ornithine decarboxylase activity and polyamine levels in the epididymis of prepubertal rat after antiandrogen administration |
| title_fullStr |
Ornithine decarboxylase activity and polyamine levels in the epididymis of prepubertal rat after antiandrogen administration |
| title_full_unstemmed |
Ornithine decarboxylase activity and polyamine levels in the epididymis of prepubertal rat after antiandrogen administration |
| title_sort |
ornithine decarboxylase activity and polyamine levels in the epididymis of prepubertal rat after antiandrogen administration |
| publishDate |
1997 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01485016_v38_n2_p163_Rulli http://hdl.handle.net/20.500.12110/paper_01485016_v38_n2_p163_Rulli |
| _version_ |
1768544589485965312 |