Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus
Estrogenic chemicals are often detected in the aquatic environment and can negatively affect animal development and reproduction. In teleost fishes, the hormonal regulation during a critical period of larval development has a strong influence on gonadal sex differentiation; thus this process may be...
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01476513_v124_n_p82_Meijide http://hdl.handle.net/20.500.12110/paper_01476513_v124_n_p82_Meijide |
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paper:paper_01476513_v124_n_p82_Meijide2023-06-08T15:12:51Z Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus Meijide, Fernando Javier Rey Vázquez, Graciela Piazza, Yanina Grisel Babay, Paola Alejandra Itria, Raúl Fabio Lo Nostro, Fabiana Laura Acute toxicity Environmental estrogens Gonad development Sex differentiation Teleosts Testicular oocytes 4 tert octylphenol estradiol 4-nonylphenol 4-tert-octylphenol estradiol estrogen phenol derivative biomarker cichlid estrogenic compound larval development pollution effect pollution exposure toxicity acute toxicity adult animal cell animal experiment animal tissue Article Cichlasoma dimerus cichlid concentration (parameters) controlled study female gonad development larval stage male nonhuman oocyte ovary development sex differentiation spermatogenesis testis development animal cichlid drug effects growth, development and aging larva ovary testis Animalia Cichlasoma Teleostei Animals Cichlids Estradiol Estrogens Female Larva Male Ovary Phenols Sex Differentiation Testis Estrogenic chemicals are often detected in the aquatic environment and can negatively affect animal development and reproduction. In teleost fishes, the hormonal regulation during a critical period of larval development has a strong influence on gonadal sex differentiation; thus this process may be affected by the exposure to environmental estrogens. In this study, we first assessed the lethal acute toxicity of the natural estrogen 17β-estradiol (E2) and the weaker estrogen mimics 4-tert-octylphenol (OP) and 4-nonylphenol (NP) on larval stages of the South American cichlid fish Cichlasoma dimerus. In a further experiment, we analyzed the effects of chronic waterborne exposure to E2 and OP on gonad development and sex differentiation. Exposure to high concentrations of E2 had a pronounced feminizing effect directing sex differentiation towards ovarian development, while testis development was inhibited at a lower, environmentally relevant concentration. Among OP-exposed fish, 15-38.5% of the males exhibited testicular oocytes (TOs), a commonly reported biomarker of estrogenic exposure. However, since TOs were also recorded in control males and the proportion of males with TOs was not significantly higher in OP treatments, their occurrence could not be attributed to OP exposure. In addition, TOs did not seem to impair male gonad development and functionality since normal spermatogenesis was observed in testes of OP-treated fish. These results indicate that E2 occurring in the South American aquatic environment may affect male reproductive development and pose a risk for wild C. dimerus, especially under prolonged exposure, while the effects of weaker xenoestrogens such as OP would be negligible for gonad development in this species. As illustrated by this study, the natural occurrence of TOs indicates that conclusions concerning the causes of this phenomenon must be drawn with care. © 2015 Elsevier Inc. Fil:Meijide, F.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rey Vázquez, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Piazza, Y.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Babay, P.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Itria, R.F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Lo Nostro, F.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01476513_v124_n_p82_Meijide http://hdl.handle.net/20.500.12110/paper_01476513_v124_n_p82_Meijide |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
Acute toxicity Environmental estrogens Gonad development Sex differentiation Teleosts Testicular oocytes 4 tert octylphenol estradiol 4-nonylphenol 4-tert-octylphenol estradiol estrogen phenol derivative biomarker cichlid estrogenic compound larval development pollution effect pollution exposure toxicity acute toxicity adult animal cell animal experiment animal tissue Article Cichlasoma dimerus cichlid concentration (parameters) controlled study female gonad development larval stage male nonhuman oocyte ovary development sex differentiation spermatogenesis testis development animal cichlid drug effects growth, development and aging larva ovary testis Animalia Cichlasoma Teleostei Animals Cichlids Estradiol Estrogens Female Larva Male Ovary Phenols Sex Differentiation Testis |
spellingShingle |
Acute toxicity Environmental estrogens Gonad development Sex differentiation Teleosts Testicular oocytes 4 tert octylphenol estradiol 4-nonylphenol 4-tert-octylphenol estradiol estrogen phenol derivative biomarker cichlid estrogenic compound larval development pollution effect pollution exposure toxicity acute toxicity adult animal cell animal experiment animal tissue Article Cichlasoma dimerus cichlid concentration (parameters) controlled study female gonad development larval stage male nonhuman oocyte ovary development sex differentiation spermatogenesis testis development animal cichlid drug effects growth, development and aging larva ovary testis Animalia Cichlasoma Teleostei Animals Cichlids Estradiol Estrogens Female Larva Male Ovary Phenols Sex Differentiation Testis Meijide, Fernando Javier Rey Vázquez, Graciela Piazza, Yanina Grisel Babay, Paola Alejandra Itria, Raúl Fabio Lo Nostro, Fabiana Laura Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus |
topic_facet |
Acute toxicity Environmental estrogens Gonad development Sex differentiation Teleosts Testicular oocytes 4 tert octylphenol estradiol 4-nonylphenol 4-tert-octylphenol estradiol estrogen phenol derivative biomarker cichlid estrogenic compound larval development pollution effect pollution exposure toxicity acute toxicity adult animal cell animal experiment animal tissue Article Cichlasoma dimerus cichlid concentration (parameters) controlled study female gonad development larval stage male nonhuman oocyte ovary development sex differentiation spermatogenesis testis development animal cichlid drug effects growth, development and aging larva ovary testis Animalia Cichlasoma Teleostei Animals Cichlids Estradiol Estrogens Female Larva Male Ovary Phenols Sex Differentiation Testis |
description |
Estrogenic chemicals are often detected in the aquatic environment and can negatively affect animal development and reproduction. In teleost fishes, the hormonal regulation during a critical period of larval development has a strong influence on gonadal sex differentiation; thus this process may be affected by the exposure to environmental estrogens. In this study, we first assessed the lethal acute toxicity of the natural estrogen 17β-estradiol (E2) and the weaker estrogen mimics 4-tert-octylphenol (OP) and 4-nonylphenol (NP) on larval stages of the South American cichlid fish Cichlasoma dimerus. In a further experiment, we analyzed the effects of chronic waterborne exposure to E2 and OP on gonad development and sex differentiation. Exposure to high concentrations of E2 had a pronounced feminizing effect directing sex differentiation towards ovarian development, while testis development was inhibited at a lower, environmentally relevant concentration. Among OP-exposed fish, 15-38.5% of the males exhibited testicular oocytes (TOs), a commonly reported biomarker of estrogenic exposure. However, since TOs were also recorded in control males and the proportion of males with TOs was not significantly higher in OP treatments, their occurrence could not be attributed to OP exposure. In addition, TOs did not seem to impair male gonad development and functionality since normal spermatogenesis was observed in testes of OP-treated fish. These results indicate that E2 occurring in the South American aquatic environment may affect male reproductive development and pose a risk for wild C. dimerus, especially under prolonged exposure, while the effects of weaker xenoestrogens such as OP would be negligible for gonad development in this species. As illustrated by this study, the natural occurrence of TOs indicates that conclusions concerning the causes of this phenomenon must be drawn with care. © 2015 Elsevier Inc. |
author |
Meijide, Fernando Javier Rey Vázquez, Graciela Piazza, Yanina Grisel Babay, Paola Alejandra Itria, Raúl Fabio Lo Nostro, Fabiana Laura |
author_facet |
Meijide, Fernando Javier Rey Vázquez, Graciela Piazza, Yanina Grisel Babay, Paola Alejandra Itria, Raúl Fabio Lo Nostro, Fabiana Laura |
author_sort |
Meijide, Fernando Javier |
title |
Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus |
title_short |
Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus |
title_full |
Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus |
title_fullStr |
Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus |
title_full_unstemmed |
Effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the South American cichlid fish Cichlasoma dimerus |
title_sort |
effects of waterborne exposure to 17β-estradiol and 4-tert-octylphenol on early life stages of the south american cichlid fish cichlasoma dimerus |
publishDate |
2016 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01476513_v124_n_p82_Meijide http://hdl.handle.net/20.500.12110/paper_01476513_v124_n_p82_Meijide |
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