Effects of six antibiotics and their binary mixtures on growth of Pseudokirchneriella subcapitata

The effect of ampicillin (AMP), amoxicillin (AMX), cephalotin (CEP), ciprofloxacin (CPF), gentamycin (GEN), and vancomycin (VAN) have been examined individually and as binary mixtures, on a non-target aquatic organism, the green alga Pseudokichneriella subcapitata. The β-lactam antibiotics AMP and A...

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Autores principales:	Magdaleno, Anahí, Juárez, Angela Beatriz
Publicado:	2015
Materias:	Antibiotic toxicity Green algae Mixture toxicity Risk quotient Synergism amoxicillin ampicillin cefalotin ciprofloxacin gentamicin vancomycin antiinfective agent antibiotics concentration (composition) ecotoxicology green alga risk assessment synergism toxicity algal growth Article concentration (parameters) controlled study ecotoxicity effluent toxicity environmental exposure growth inhibition molecular interaction nonhuman prediction Selenastrum capricornutum toxicity testing waste water water pollution drug effects drug interaction growth, development and aging Argentina Buenos Aires [Argentina] Chlorophyta Anti-Bacterial Agents Drug Interactions Risk Assessment
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01476513_v113_n_p72_Magdaleno http://hdl.handle.net/20.500.12110/paper_01476513_v113_n_p72_Magdaleno
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	paper:paper_01476513_v113_n_p72_Magdaleno2023-06-08T15:12:49Z Effects of six antibiotics and their binary mixtures on growth of Pseudokirchneriella subcapitata Magdaleno, Anahí Juárez, Angela Beatriz Antibiotic toxicity Green algae Mixture toxicity Risk quotient Synergism amoxicillin ampicillin cefalotin ciprofloxacin gentamicin vancomycin antiinfective agent antibiotics concentration (composition) ecotoxicology green alga risk assessment synergism toxicity algal growth Article concentration (parameters) controlled study ecotoxicity effluent toxicity environmental exposure growth inhibition molecular interaction nonhuman prediction risk assessment Selenastrum capricornutum toxicity testing waste water water pollution drug effects drug interaction green alga growth, development and aging Argentina Buenos Aires [Argentina] Chlorophyta Selenastrum capricornutum Anti-Bacterial Agents Chlorophyta Drug Interactions Risk Assessment The effect of ampicillin (AMP), amoxicillin (AMX), cephalotin (CEP), ciprofloxacin (CPF), gentamycin (GEN), and vancomycin (VAN) have been examined individually and as binary mixtures, on a non-target aquatic organism, the green alga Pseudokichneriella subcapitata. The β-lactam antibiotics AMP and AMX were not toxic to the alga at concentrations up to 2000mgl-1 (less than 10% of algal growth inhibition), whereas the fluoroquinolone CPF, and the aminoglycoside GEN were the most toxic antibiotics, with an EC50=11.3±0.7mgl-1 and 19.2±0.5mgl-1, respectively. The cephalosporin CEP and the glycopeptide VAN were less toxic than the last two mentioned, showing an EC50>600mgl-1 and 724±20mgl-1, respectively. The toxicological interactions of binary mixtures were predicted by the two classical models of additivity: concentration addition (CA) and independent action (IA), and compared to the experimentally determined toxicities over a range of concentrations between 1 and 50mgl-1. In all cases a clear synergistic effect was observed, showing that single compound toxicity data are not adequate for the prediction of aquatic toxicities of antibiotic mixtures. Risk assessment was performed by calculating the ratio between predicted environmental concentrations (PEC) and the predicted no effect concentration (PNEC). All the antibiotics tested, excepting GEN, have a potential ecological risk, taking into account the PEC of hospital effluents from Buenos Aires, Argentina. These risks increase when antibiotics are present in binary mixtures. © 2014 Elsevier Inc. Fil:Magdaleno, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Juárez, A.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01476513_v113_n_p72_Magdaleno http://hdl.handle.net/20.500.12110/paper_01476513_v113_n_p72_Magdaleno
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Antibiotic toxicity Green algae Mixture toxicity Risk quotient Synergism amoxicillin ampicillin cefalotin ciprofloxacin gentamicin vancomycin antiinfective agent antibiotics concentration (composition) ecotoxicology green alga risk assessment synergism toxicity algal growth Article concentration (parameters) controlled study ecotoxicity effluent toxicity environmental exposure growth inhibition molecular interaction nonhuman prediction risk assessment Selenastrum capricornutum toxicity testing waste water water pollution drug effects drug interaction green alga growth, development and aging Argentina Buenos Aires [Argentina] Chlorophyta Selenastrum capricornutum Anti-Bacterial Agents Chlorophyta Drug Interactions Risk Assessment
spellingShingle	Antibiotic toxicity Green algae Mixture toxicity Risk quotient Synergism amoxicillin ampicillin cefalotin ciprofloxacin gentamicin vancomycin antiinfective agent antibiotics concentration (composition) ecotoxicology green alga risk assessment synergism toxicity algal growth Article concentration (parameters) controlled study ecotoxicity effluent toxicity environmental exposure growth inhibition molecular interaction nonhuman prediction risk assessment Selenastrum capricornutum toxicity testing waste water water pollution drug effects drug interaction green alga growth, development and aging Argentina Buenos Aires [Argentina] Chlorophyta Selenastrum capricornutum Anti-Bacterial Agents Chlorophyta Drug Interactions Risk Assessment Magdaleno, Anahí Juárez, Angela Beatriz Effects of six antibiotics and their binary mixtures on growth of Pseudokirchneriella subcapitata
topic_facet	Antibiotic toxicity Green algae Mixture toxicity Risk quotient Synergism amoxicillin ampicillin cefalotin ciprofloxacin gentamicin vancomycin antiinfective agent antibiotics concentration (composition) ecotoxicology green alga risk assessment synergism toxicity algal growth Article concentration (parameters) controlled study ecotoxicity effluent toxicity environmental exposure growth inhibition molecular interaction nonhuman prediction risk assessment Selenastrum capricornutum toxicity testing waste water water pollution drug effects drug interaction green alga growth, development and aging Argentina Buenos Aires [Argentina] Chlorophyta Selenastrum capricornutum Anti-Bacterial Agents Chlorophyta Drug Interactions Risk Assessment
description	The effect of ampicillin (AMP), amoxicillin (AMX), cephalotin (CEP), ciprofloxacin (CPF), gentamycin (GEN), and vancomycin (VAN) have been examined individually and as binary mixtures, on a non-target aquatic organism, the green alga Pseudokichneriella subcapitata. The β-lactam antibiotics AMP and AMX were not toxic to the alga at concentrations up to 2000mgl-1 (less than 10% of algal growth inhibition), whereas the fluoroquinolone CPF, and the aminoglycoside GEN were the most toxic antibiotics, with an EC50=11.3±0.7mgl-1 and 19.2±0.5mgl-1, respectively. The cephalosporin CEP and the glycopeptide VAN were less toxic than the last two mentioned, showing an EC50>600mgl-1 and 724±20mgl-1, respectively. The toxicological interactions of binary mixtures were predicted by the two classical models of additivity: concentration addition (CA) and independent action (IA), and compared to the experimentally determined toxicities over a range of concentrations between 1 and 50mgl-1. In all cases a clear synergistic effect was observed, showing that single compound toxicity data are not adequate for the prediction of aquatic toxicities of antibiotic mixtures. Risk assessment was performed by calculating the ratio between predicted environmental concentrations (PEC) and the predicted no effect concentration (PNEC). All the antibiotics tested, excepting GEN, have a potential ecological risk, taking into account the PEC of hospital effluents from Buenos Aires, Argentina. These risks increase when antibiotics are present in binary mixtures. © 2014 Elsevier Inc.
author	Magdaleno, Anahí Juárez, Angela Beatriz
author_facet	Magdaleno, Anahí Juárez, Angela Beatriz
author_sort	Magdaleno, Anahí
title	Effects of six antibiotics and their binary mixtures on growth of Pseudokirchneriella subcapitata
title_short	Effects of six antibiotics and their binary mixtures on growth of Pseudokirchneriella subcapitata
title_full	Effects of six antibiotics and their binary mixtures on growth of Pseudokirchneriella subcapitata
title_fullStr	Effects of six antibiotics and their binary mixtures on growth of Pseudokirchneriella subcapitata
title_full_unstemmed	Effects of six antibiotics and their binary mixtures on growth of Pseudokirchneriella subcapitata
title_sort	effects of six antibiotics and their binary mixtures on growth of pseudokirchneriella subcapitata
publishDate	2015
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01476513_v113_n_p72_Magdaleno http://hdl.handle.net/20.500.12110/paper_01476513_v113_n_p72_Magdaleno
work_keys_str_mv	AT magdalenoanahi effectsofsixantibioticsandtheirbinarymixturesongrowthofpseudokirchneriellasubcapitata AT juarezangelabeatriz effectsofsixantibioticsandtheirbinarymixturesongrowthofpseudokirchneriellasubcapitata
_version_	1768544219739193344

Effects of six antibiotics and their binary mixtures on growth of Pseudokirchneriella subcapitata

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