Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities
Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry. This study demonstrates the potential of chemically engineered sulfated xylomannans from Scinaia hatei as antiHSV drug candidate. Particularly, a dimethylformamide...
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2015
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01448617_v131_n_p315_Ray http://hdl.handle.net/20.500.12110/paper_01448617_v131_n_p315_Ray |
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paper:paper_01448617_v131_n_p315_Ray2023-06-08T15:12:00Z Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities Antiviral drug candidate Cytotoxicity Polysaccharide engineering Scinaia hatei Bioactivity Cell membranes Cytotoxicity Molecular mass Viruses Anionic polysaccharides Anti-viral drugs Antiviral activities Cell-surface heparan Herpes simplex virus Hydroxyl functionality Molecular entities Scinaia hatei Sulfur compounds Human herpesvirus 1 Human herpesvirus 2 Scinaia Simplexvirus antivirus agent glycoside oligosaccharide sulfate xylomannan animal chemistry Chlorocebus aethiops drug effects Herpes simplex virus 1 infrared spectroscopy isolation and purification molecular weight red alga Vero cell line Animals Antiviral Agents Cercopithecus aethiops Glycosides Herpesvirus 1, Human Molecular Weight Oligosaccharides Rhodophyta Spectroscopy, Fourier Transform Infrared Sulfates Vero Cells Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry. This study demonstrates the potential of chemically engineered sulfated xylomannans from Scinaia hatei as antiHSV drug candidate. Particularly, a dimethylformamide -SO<inf>3</inf>/pyridine based procedure has been employed for the generation of anionic polysaccharides. This one-step procedure has the power of providing a spectrum of xylomannans with varying molecular masses (<12-74 kDa), sulfate content (1-50%) and glycosyl composition. Especially, the sulfated xylomannans S1F1 and S2F1 possessed altered activity against HSV-1 and HSV-2 compared to the parental compound (F1) and that too in the absence of drug-induced cytotoxicity. Regarding methodological facet, the directive decoration of hydroxyl functionality with sulfate group plus changes in the molecular mass and sugar composition during isolation by the used reagent opens a door for the production of new molecular entity with altered biological activity from other natural sources. © 2015 Elsevier B.V. All rights reserved. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01448617_v131_n_p315_Ray http://hdl.handle.net/20.500.12110/paper_01448617_v131_n_p315_Ray |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Antiviral drug candidate Cytotoxicity Polysaccharide engineering Scinaia hatei Bioactivity Cell membranes Cytotoxicity Molecular mass Viruses Anionic polysaccharides Anti-viral drugs Antiviral activities Cell-surface heparan Herpes simplex virus Hydroxyl functionality Molecular entities Scinaia hatei Sulfur compounds Human herpesvirus 1 Human herpesvirus 2 Scinaia Simplexvirus antivirus agent glycoside oligosaccharide sulfate xylomannan animal chemistry Chlorocebus aethiops drug effects Herpes simplex virus 1 infrared spectroscopy isolation and purification molecular weight red alga Vero cell line Animals Antiviral Agents Cercopithecus aethiops Glycosides Herpesvirus 1, Human Molecular Weight Oligosaccharides Rhodophyta Spectroscopy, Fourier Transform Infrared Sulfates Vero Cells |
| spellingShingle |
Antiviral drug candidate Cytotoxicity Polysaccharide engineering Scinaia hatei Bioactivity Cell membranes Cytotoxicity Molecular mass Viruses Anionic polysaccharides Anti-viral drugs Antiviral activities Cell-surface heparan Herpes simplex virus Hydroxyl functionality Molecular entities Scinaia hatei Sulfur compounds Human herpesvirus 1 Human herpesvirus 2 Scinaia Simplexvirus antivirus agent glycoside oligosaccharide sulfate xylomannan animal chemistry Chlorocebus aethiops drug effects Herpes simplex virus 1 infrared spectroscopy isolation and purification molecular weight red alga Vero cell line Animals Antiviral Agents Cercopithecus aethiops Glycosides Herpesvirus 1, Human Molecular Weight Oligosaccharides Rhodophyta Spectroscopy, Fourier Transform Infrared Sulfates Vero Cells Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities |
| topic_facet |
Antiviral drug candidate Cytotoxicity Polysaccharide engineering Scinaia hatei Bioactivity Cell membranes Cytotoxicity Molecular mass Viruses Anionic polysaccharides Anti-viral drugs Antiviral activities Cell-surface heparan Herpes simplex virus Hydroxyl functionality Molecular entities Scinaia hatei Sulfur compounds Human herpesvirus 1 Human herpesvirus 2 Scinaia Simplexvirus antivirus agent glycoside oligosaccharide sulfate xylomannan animal chemistry Chlorocebus aethiops drug effects Herpes simplex virus 1 infrared spectroscopy isolation and purification molecular weight red alga Vero cell line Animals Antiviral Agents Cercopithecus aethiops Glycosides Herpesvirus 1, Human Molecular Weight Oligosaccharides Rhodophyta Spectroscopy, Fourier Transform Infrared Sulfates Vero Cells |
| description |
Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry. This study demonstrates the potential of chemically engineered sulfated xylomannans from Scinaia hatei as antiHSV drug candidate. Particularly, a dimethylformamide -SO<inf>3</inf>/pyridine based procedure has been employed for the generation of anionic polysaccharides. This one-step procedure has the power of providing a spectrum of xylomannans with varying molecular masses (<12-74 kDa), sulfate content (1-50%) and glycosyl composition. Especially, the sulfated xylomannans S1F1 and S2F1 possessed altered activity against HSV-1 and HSV-2 compared to the parental compound (F1) and that too in the absence of drug-induced cytotoxicity. Regarding methodological facet, the directive decoration of hydroxyl functionality with sulfate group plus changes in the molecular mass and sugar composition during isolation by the used reagent opens a door for the production of new molecular entity with altered biological activity from other natural sources. © 2015 Elsevier B.V. All rights reserved. |
| title |
Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities |
| title_short |
Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities |
| title_full |
Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities |
| title_fullStr |
Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities |
| title_full_unstemmed |
Additionally sulfated xylomannan sulfates from Scinaia hatei and their antiviral activities |
| title_sort |
additionally sulfated xylomannan sulfates from scinaia hatei and their antiviral activities |
| publishDate |
2015 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01448617_v131_n_p315_Ray http://hdl.handle.net/20.500.12110/paper_01448617_v131_n_p315_Ray |
| _version_ |
1768546153899491328 |