Photophysics and photobiology of novel liposomal formulations of 2,9(10), 16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II)
Six novel liposomal formulations of 2,9(10),16(17),23(24)-tetrakis[(2- dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) (Pc9) were investigated to establish how the environments affect their photophysical and photobiological properties. The incorporation efficiency and solubility during a time p...
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2013
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01437208_v96_n3_p626_LopezZeballos http://hdl.handle.net/20.500.12110/paper_01437208_v96_n3_p626_LopezZeballos |
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paper:paper_01437208_v96_n3_p626_LopezZeballos2023-06-08T15:11:55Z Photophysics and photobiology of novel liposomal formulations of 2,9(10), 16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) KB cells Liposome Photocytotoxicity Photodynamic therapy Phthalocyanine Singlet oxygen Carcinoma cells Cytotoxic effects Liposomal formulation Photobiology Photocytotoxicity Photophysical Photophysics Phthalocyanine Singlet oxygen Tetrakis Time-periods Cell proliferation Liposomes Oxygen Photodynamic therapy Quantum yield Cytotoxicity Six novel liposomal formulations of 2,9(10),16(17),23(24)-tetrakis[(2- dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) (Pc9) were investigated to establish how the environments affect their photophysical and photobiological properties. The incorporation efficiency and solubility during a time period were evaluated. All Pc9-liposomal formulations were efficient singlet oxygen quantum yield generators. The photobiological potentials were evaluated on human nasopharynx KB carcinoma cells. None of the formulations studied showed cytotoxic effects in the absence of light, whereas all of them showed good performance after irradiation. The 50% inhibition of cell proliferation (IC 50) was in the range of 0.21-0.47 μM for Pc9-loaded liposome formulations. A lysosomal localization was found for S-PEG as well as for S. © 2012 Elsevier Ltd. All rights reserved. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01437208_v96_n3_p626_LopezZeballos http://hdl.handle.net/20.500.12110/paper_01437208_v96_n3_p626_LopezZeballos |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
KB cells Liposome Photocytotoxicity Photodynamic therapy Phthalocyanine Singlet oxygen Carcinoma cells Cytotoxic effects Liposomal formulation Photobiology Photocytotoxicity Photophysical Photophysics Phthalocyanine Singlet oxygen Tetrakis Time-periods Cell proliferation Liposomes Oxygen Photodynamic therapy Quantum yield Cytotoxicity |
| spellingShingle |
KB cells Liposome Photocytotoxicity Photodynamic therapy Phthalocyanine Singlet oxygen Carcinoma cells Cytotoxic effects Liposomal formulation Photobiology Photocytotoxicity Photophysical Photophysics Phthalocyanine Singlet oxygen Tetrakis Time-periods Cell proliferation Liposomes Oxygen Photodynamic therapy Quantum yield Cytotoxicity Photophysics and photobiology of novel liposomal formulations of 2,9(10), 16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) |
| topic_facet |
KB cells Liposome Photocytotoxicity Photodynamic therapy Phthalocyanine Singlet oxygen Carcinoma cells Cytotoxic effects Liposomal formulation Photobiology Photocytotoxicity Photophysical Photophysics Phthalocyanine Singlet oxygen Tetrakis Time-periods Cell proliferation Liposomes Oxygen Photodynamic therapy Quantum yield Cytotoxicity |
| description |
Six novel liposomal formulations of 2,9(10),16(17),23(24)-tetrakis[(2- dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) (Pc9) were investigated to establish how the environments affect their photophysical and photobiological properties. The incorporation efficiency and solubility during a time period were evaluated. All Pc9-liposomal formulations were efficient singlet oxygen quantum yield generators. The photobiological potentials were evaluated on human nasopharynx KB carcinoma cells. None of the formulations studied showed cytotoxic effects in the absence of light, whereas all of them showed good performance after irradiation. The 50% inhibition of cell proliferation (IC 50) was in the range of 0.21-0.47 μM for Pc9-loaded liposome formulations. A lysosomal localization was found for S-PEG as well as for S. © 2012 Elsevier Ltd. All rights reserved. |
| title |
Photophysics and photobiology of novel liposomal formulations of 2,9(10), 16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) |
| title_short |
Photophysics and photobiology of novel liposomal formulations of 2,9(10), 16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) |
| title_full |
Photophysics and photobiology of novel liposomal formulations of 2,9(10), 16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) |
| title_fullStr |
Photophysics and photobiology of novel liposomal formulations of 2,9(10), 16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) |
| title_full_unstemmed |
Photophysics and photobiology of novel liposomal formulations of 2,9(10), 16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) |
| title_sort |
photophysics and photobiology of novel liposomal formulations of 2,9(10), 16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(ii) |
| publishDate |
2013 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01437208_v96_n3_p626_LopezZeballos http://hdl.handle.net/20.500.12110/paper_01437208_v96_n3_p626_LopezZeballos |
| _version_ |
1768544173222264832 |