A comparative study of a novel lipophilic phthalocyanine incorporated into nanoemulsion formulations: Photophysics, size, solubility and thermodynamic stability
Lipophilic tetrakis-(1-adamantylsulfanyl)phthalocyaninatozinc(II) was incorporated into two different nanoemulsion formulations with the former emulsion containing isopropyl myristate and Tween 80® and the latter glycerol monocaprylocaprate and Tween 80®. A two- to three-fold increase in water solub...
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2011
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01437208_v91_n2_p208_GarciaVior http://hdl.handle.net/20.500.12110/paper_01437208_v91_n2_p208_GarciaVior |
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paper:paper_01437208_v91_n2_p208_GarciaVior2023-06-08T15:11:55Z A comparative study of a novel lipophilic phthalocyanine incorporated into nanoemulsion formulations: Photophysics, size, solubility and thermodynamic stability Nanoemulsions Photodynamic therapy Singlet oxygen Solubility Thermodynamic stability Zinc(II) phthalocyanines Clinical trial Comparative studies Isopropyl myristate Nano-emulsions Nano-size Nanoemulsion Parenteral administration Photophysics Singlet oxygen Singlet oxygen generation Singlet oxygen production Tetrakis Thermodynamically stable Tween 80 Water solubilities Zinc phthalocyanines Emulsification Gas generators Glycerol Oxygen Photodynamic therapy Plasmons Quantum yield Solubility Thermodynamic stability Zinc Zinc compounds Nitrogen compounds Lipophilic tetrakis-(1-adamantylsulfanyl)phthalocyaninatozinc(II) was incorporated into two different nanoemulsion formulations with the former emulsion containing isopropyl myristate and Tween 80® and the latter glycerol monocaprylocaprate and Tween 80®. A two- to three-fold increase in water solubility was observed for the zinc phthalocyanine when incorporated into the nanoemulsions in comparison with that observed for water-DMSO (98:2). Morphological evaluation confirmed the formation of thermodynamically stable nanoemulsions in the nanosize range. The zinc phthalocyanine incorporated into the nanoemulsions was photo-stable over the irradiation times studied and both formulations displayed excellent singlet oxygen generation ability with high values of quantum yield of singlet oxygen production of up to 0.58. In addition, the viscosity of the nanoemulsions ranged from 30.2 to 323.9 cP. The foregoing formulations are considered to be strong candidates for parenteral administration of the zinc phthalocyanine in photodynamic therapy clinical trials. © 2011 Elsevier Ltd. All rights reserved. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01437208_v91_n2_p208_GarciaVior http://hdl.handle.net/20.500.12110/paper_01437208_v91_n2_p208_GarciaVior |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Nanoemulsions Photodynamic therapy Singlet oxygen Solubility Thermodynamic stability Zinc(II) phthalocyanines Clinical trial Comparative studies Isopropyl myristate Nano-emulsions Nano-size Nanoemulsion Parenteral administration Photophysics Singlet oxygen Singlet oxygen generation Singlet oxygen production Tetrakis Thermodynamically stable Tween 80 Water solubilities Zinc phthalocyanines Emulsification Gas generators Glycerol Oxygen Photodynamic therapy Plasmons Quantum yield Solubility Thermodynamic stability Zinc Zinc compounds Nitrogen compounds |
| spellingShingle |
Nanoemulsions Photodynamic therapy Singlet oxygen Solubility Thermodynamic stability Zinc(II) phthalocyanines Clinical trial Comparative studies Isopropyl myristate Nano-emulsions Nano-size Nanoemulsion Parenteral administration Photophysics Singlet oxygen Singlet oxygen generation Singlet oxygen production Tetrakis Thermodynamically stable Tween 80 Water solubilities Zinc phthalocyanines Emulsification Gas generators Glycerol Oxygen Photodynamic therapy Plasmons Quantum yield Solubility Thermodynamic stability Zinc Zinc compounds Nitrogen compounds A comparative study of a novel lipophilic phthalocyanine incorporated into nanoemulsion formulations: Photophysics, size, solubility and thermodynamic stability |
| topic_facet |
Nanoemulsions Photodynamic therapy Singlet oxygen Solubility Thermodynamic stability Zinc(II) phthalocyanines Clinical trial Comparative studies Isopropyl myristate Nano-emulsions Nano-size Nanoemulsion Parenteral administration Photophysics Singlet oxygen Singlet oxygen generation Singlet oxygen production Tetrakis Thermodynamically stable Tween 80 Water solubilities Zinc phthalocyanines Emulsification Gas generators Glycerol Oxygen Photodynamic therapy Plasmons Quantum yield Solubility Thermodynamic stability Zinc Zinc compounds Nitrogen compounds |
| description |
Lipophilic tetrakis-(1-adamantylsulfanyl)phthalocyaninatozinc(II) was incorporated into two different nanoemulsion formulations with the former emulsion containing isopropyl myristate and Tween 80® and the latter glycerol monocaprylocaprate and Tween 80®. A two- to three-fold increase in water solubility was observed for the zinc phthalocyanine when incorporated into the nanoemulsions in comparison with that observed for water-DMSO (98:2). Morphological evaluation confirmed the formation of thermodynamically stable nanoemulsions in the nanosize range. The zinc phthalocyanine incorporated into the nanoemulsions was photo-stable over the irradiation times studied and both formulations displayed excellent singlet oxygen generation ability with high values of quantum yield of singlet oxygen production of up to 0.58. In addition, the viscosity of the nanoemulsions ranged from 30.2 to 323.9 cP. The foregoing formulations are considered to be strong candidates for parenteral administration of the zinc phthalocyanine in photodynamic therapy clinical trials. © 2011 Elsevier Ltd. All rights reserved. |
| title |
A comparative study of a novel lipophilic phthalocyanine incorporated into nanoemulsion formulations: Photophysics, size, solubility and thermodynamic stability |
| title_short |
A comparative study of a novel lipophilic phthalocyanine incorporated into nanoemulsion formulations: Photophysics, size, solubility and thermodynamic stability |
| title_full |
A comparative study of a novel lipophilic phthalocyanine incorporated into nanoemulsion formulations: Photophysics, size, solubility and thermodynamic stability |
| title_fullStr |
A comparative study of a novel lipophilic phthalocyanine incorporated into nanoemulsion formulations: Photophysics, size, solubility and thermodynamic stability |
| title_full_unstemmed |
A comparative study of a novel lipophilic phthalocyanine incorporated into nanoemulsion formulations: Photophysics, size, solubility and thermodynamic stability |
| title_sort |
comparative study of a novel lipophilic phthalocyanine incorporated into nanoemulsion formulations: photophysics, size, solubility and thermodynamic stability |
| publishDate |
2011 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01437208_v91_n2_p208_GarciaVior http://hdl.handle.net/20.500.12110/paper_01437208_v91_n2_p208_GarciaVior |
| _version_ |
1768542262478766080 |