Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides

Diverse classes of sulfated polysaccharides obtained from the red seaweeds (Rhodophyta) Grateloupia indica, Scinaia hatei and Gracilaria corticata, the brown seaweeds (Phaeophyta) Stoechospermum marginatum and Cystoseira indica and the green seaweed (Chlorophyta) Caulerpa racemosa were assayed for a...

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Autores principales:	Pujol, Carlos Alberto, Damonte, Elsa Beatriz
Publicado:	2012
Materias:	Algal sulfated polysaccharides Antiviral activity Dengue virus Sugar composition algal extract antivirus agent dextran sulfate ds 8000 fucan sulfate galactan galactan sulfate heparin hot water polysaccharide sulfate unclassified drug xylomannan sulfate animal cell antiviral activity antiviral susceptibility article brown alga carbohydrate analysis Caulerpa racemosa cell viability Cystoseira indica dengue Dengue virus 1 Dengue virus 2 Dengue virus 3 Dengue virus 4 drug cytotoxicity drug determination drug efficacy drug isolation drug potency drug structure Gracilaria corticata Grateloupia indica green alga IC 50 in vitro study infection control molecular weight nonhuman red alga Scinaia hatei Stoechospermum marginatum structure activity relation Vero cell virus attachment virus entry virus inhibition Animals Antiviral Agents Cercopithecus aethiops Chlorophyta Dengue Virus Phaeophyta Polysaccharides Rhodophyta Sulfates Vero Cells algae Grateloupia Phaeophyceae Scinaia
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01418130_v51_n4_p412_Pujol http://hdl.handle.net/20.500.12110/paper_01418130_v51_n4_p412_Pujol
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_01418130_v51_n4_p412_Pujol
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spelling	paper:paper_01418130_v51_n4_p412_Pujol2023-06-08T15:11:24Z Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides Pujol, Carlos Alberto Damonte, Elsa Beatriz Algal sulfated polysaccharides Antiviral activity Dengue virus Sugar composition algal extract antivirus agent dextran sulfate ds 8000 fucan sulfate galactan galactan sulfate heparin hot water polysaccharide sulfate unclassified drug xylomannan sulfate animal cell antiviral activity antiviral susceptibility article brown alga carbohydrate analysis Caulerpa racemosa cell viability Cystoseira indica dengue Dengue virus Dengue virus 1 Dengue virus 2 Dengue virus 3 Dengue virus 4 drug cytotoxicity drug determination drug efficacy drug isolation drug potency drug structure Gracilaria corticata Grateloupia indica green alga IC 50 in vitro study infection control molecular weight nonhuman red alga Scinaia hatei Stoechospermum marginatum structure activity relation Vero cell virus attachment virus entry virus inhibition Animals Antiviral Agents Cercopithecus aethiops Chlorophyta Dengue Virus Phaeophyta Polysaccharides Rhodophyta Sulfates Vero Cells algae Caulerpa racemosa Chlorophyta Cystoseira indica Dengue virus Gracilaria corticata Grateloupia Phaeophyceae Rhodophyta Scinaia Stoechospermum marginatum Diverse classes of sulfated polysaccharides obtained from the red seaweeds (Rhodophyta) Grateloupia indica, Scinaia hatei and Gracilaria corticata, the brown seaweeds (Phaeophyta) Stoechospermum marginatum and Cystoseira indica and the green seaweed (Chlorophyta) Caulerpa racemosa were assayed for antiviral activity against the four serotypes of dengue virus (DENV). DENV-2 was the most susceptible serotype to all polysulfates, with inhibitory concentration 50% values in the range 0.12-20. μg/mL. The antiviral potency of the sulfated polysaccharides depended on the sulfate content, the position of sulfate group, the sugar composition, and the molar mass. Independently of the sugar composition, the antiviral effect was mainly exerted during DENV-2 adsorption and internalization. © 2012 Elsevier B.V. Fil:Pujol, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01418130_v51_n4_p412_Pujol http://hdl.handle.net/20.500.12110/paper_01418130_v51_n4_p412_Pujol
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Algal sulfated polysaccharides Antiviral activity Dengue virus Sugar composition algal extract antivirus agent dextran sulfate ds 8000 fucan sulfate galactan galactan sulfate heparin hot water polysaccharide sulfate unclassified drug xylomannan sulfate animal cell antiviral activity antiviral susceptibility article brown alga carbohydrate analysis Caulerpa racemosa cell viability Cystoseira indica dengue Dengue virus Dengue virus 1 Dengue virus 2 Dengue virus 3 Dengue virus 4 drug cytotoxicity drug determination drug efficacy drug isolation drug potency drug structure Gracilaria corticata Grateloupia indica green alga IC 50 in vitro study infection control molecular weight nonhuman red alga Scinaia hatei Stoechospermum marginatum structure activity relation Vero cell virus attachment virus entry virus inhibition Animals Antiviral Agents Cercopithecus aethiops Chlorophyta Dengue Virus Phaeophyta Polysaccharides Rhodophyta Sulfates Vero Cells algae Caulerpa racemosa Chlorophyta Cystoseira indica Dengue virus Gracilaria corticata Grateloupia Phaeophyceae Rhodophyta Scinaia Stoechospermum marginatum
spellingShingle	Algal sulfated polysaccharides Antiviral activity Dengue virus Sugar composition algal extract antivirus agent dextran sulfate ds 8000 fucan sulfate galactan galactan sulfate heparin hot water polysaccharide sulfate unclassified drug xylomannan sulfate animal cell antiviral activity antiviral susceptibility article brown alga carbohydrate analysis Caulerpa racemosa cell viability Cystoseira indica dengue Dengue virus Dengue virus 1 Dengue virus 2 Dengue virus 3 Dengue virus 4 drug cytotoxicity drug determination drug efficacy drug isolation drug potency drug structure Gracilaria corticata Grateloupia indica green alga IC 50 in vitro study infection control molecular weight nonhuman red alga Scinaia hatei Stoechospermum marginatum structure activity relation Vero cell virus attachment virus entry virus inhibition Animals Antiviral Agents Cercopithecus aethiops Chlorophyta Dengue Virus Phaeophyta Polysaccharides Rhodophyta Sulfates Vero Cells algae Caulerpa racemosa Chlorophyta Cystoseira indica Dengue virus Gracilaria corticata Grateloupia Phaeophyceae Rhodophyta Scinaia Stoechospermum marginatum Pujol, Carlos Alberto Damonte, Elsa Beatriz Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides
topic_facet	Algal sulfated polysaccharides Antiviral activity Dengue virus Sugar composition algal extract antivirus agent dextran sulfate ds 8000 fucan sulfate galactan galactan sulfate heparin hot water polysaccharide sulfate unclassified drug xylomannan sulfate animal cell antiviral activity antiviral susceptibility article brown alga carbohydrate analysis Caulerpa racemosa cell viability Cystoseira indica dengue Dengue virus Dengue virus 1 Dengue virus 2 Dengue virus 3 Dengue virus 4 drug cytotoxicity drug determination drug efficacy drug isolation drug potency drug structure Gracilaria corticata Grateloupia indica green alga IC 50 in vitro study infection control molecular weight nonhuman red alga Scinaia hatei Stoechospermum marginatum structure activity relation Vero cell virus attachment virus entry virus inhibition Animals Antiviral Agents Cercopithecus aethiops Chlorophyta Dengue Virus Phaeophyta Polysaccharides Rhodophyta Sulfates Vero Cells algae Caulerpa racemosa Chlorophyta Cystoseira indica Dengue virus Gracilaria corticata Grateloupia Phaeophyceae Rhodophyta Scinaia Stoechospermum marginatum
description	Diverse classes of sulfated polysaccharides obtained from the red seaweeds (Rhodophyta) Grateloupia indica, Scinaia hatei and Gracilaria corticata, the brown seaweeds (Phaeophyta) Stoechospermum marginatum and Cystoseira indica and the green seaweed (Chlorophyta) Caulerpa racemosa were assayed for antiviral activity against the four serotypes of dengue virus (DENV). DENV-2 was the most susceptible serotype to all polysulfates, with inhibitory concentration 50% values in the range 0.12-20. μg/mL. The antiviral potency of the sulfated polysaccharides depended on the sulfate content, the position of sulfate group, the sugar composition, and the molar mass. Independently of the sugar composition, the antiviral effect was mainly exerted during DENV-2 adsorption and internalization. © 2012 Elsevier B.V.
author	Pujol, Carlos Alberto Damonte, Elsa Beatriz
author_facet	Pujol, Carlos Alberto Damonte, Elsa Beatriz
author_sort	Pujol, Carlos Alberto
title	Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides
title_short	Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides
title_full	Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides
title_fullStr	Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides
title_full_unstemmed	Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides
title_sort	antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides
publishDate	2012
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01418130_v51_n4_p412_Pujol http://hdl.handle.net/20.500.12110/paper_01418130_v51_n4_p412_Pujol
work_keys_str_mv	AT pujolcarlosalberto antiviralactivityagainstdenguevirusofdiverseclassesofalgalsulfatedpolysaccharides AT damonteelsabeatriz antiviralactivityagainstdenguevirusofdiverseclassesofalgalsulfatedpolysaccharides
_version_	1768542591538692096

Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides

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