Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists
A visual danger stimulus (VDS) elicits an escape response in the crab Chasmagnathus that declines after a few iterative presentations. Long-lasting retention of such decrement, termed context-signal memory (CSM), is mediated by an association between danger stimulus and environmental cues, cyclohexi...
| Publicado: |
2002
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913057_v72_n1-2_p251_Troncoso http://hdl.handle.net/20.500.12110/paper_00913057_v72_n1-2_p251_Troncoso |
| Aporte de: |
| id |
paper:paper_00913057_v72_n1-2_p251_Troncoso |
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| record_format |
dspace |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
AP5: MK-801 Crab Crustacea Learning Memory NMDA 2 amino 5 phosphonovaleric acid angiotensin cyclic AMP dependent protein kinase cycloheximide dizocilpine immunoglobulin enhancer binding protein n methyl dextro aspartic acid receptor n methyl dextro aspartic acid receptor blocking agent amino acid receptor blocking agent n methyl dextro aspartic acid receptor amnesia article associative memory controlled study crab Crustacea dose response drug effect environment enzyme activity male memory memory consolidation nonhuman priority journal stimulus training animal Brachyura comparative study drug antagonism physiology Chasmagnathus Crustacea Decapoda (Crustacea) Invertebrata Vertebrata Animals Brachyura Excitatory Amino Acid Antagonists Male Memory Receptors, N-Methyl-D-Aspartate |
| spellingShingle |
AP5: MK-801 Crab Crustacea Learning Memory NMDA 2 amino 5 phosphonovaleric acid angiotensin cyclic AMP dependent protein kinase cycloheximide dizocilpine immunoglobulin enhancer binding protein n methyl dextro aspartic acid receptor n methyl dextro aspartic acid receptor blocking agent amino acid receptor blocking agent n methyl dextro aspartic acid receptor amnesia article associative memory controlled study crab Crustacea dose response drug effect environment enzyme activity male memory memory consolidation nonhuman priority journal stimulus training animal Brachyura comparative study drug antagonism physiology Chasmagnathus Crustacea Decapoda (Crustacea) Invertebrata Vertebrata Animals Brachyura Excitatory Amino Acid Antagonists Male Memory Receptors, N-Methyl-D-Aspartate Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists |
| topic_facet |
AP5: MK-801 Crab Crustacea Learning Memory NMDA 2 amino 5 phosphonovaleric acid angiotensin cyclic AMP dependent protein kinase cycloheximide dizocilpine immunoglobulin enhancer binding protein n methyl dextro aspartic acid receptor n methyl dextro aspartic acid receptor blocking agent amino acid receptor blocking agent n methyl dextro aspartic acid receptor amnesia article associative memory controlled study crab Crustacea dose response drug effect environment enzyme activity male memory memory consolidation nonhuman priority journal stimulus training animal Brachyura comparative study drug antagonism physiology Chasmagnathus Crustacea Decapoda (Crustacea) Invertebrata Vertebrata Animals Brachyura Excitatory Amino Acid Antagonists Male Memory Receptors, N-Methyl-D-Aspartate |
| description |
A visual danger stimulus (VDS) elicits an escape response in the crab Chasmagnathus that declines after a few iterative presentations. Long-lasting retention of such decrement, termed context-signal memory (CSM), is mediated by an association between danger stimulus and environmental cues, cycloheximide sensitive, correlated with PKA activity and NFκ-B activation, positively modulated by angiotensins, and selectively regulated by a muscarinic-cholinergic mechanism. The present research was aimed at studying the possible involvement of NMDA-like receptors in CSM, given the role attributed to these receptors in vertebrate memory and their occurrence in invertebrates including crustaceans. Vertebrate antagonists (±)-2-amino-5-phosphonopentanoic acid (AP5) and (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) were used. Memory retention impairment was shown with MK-801 10-3 M (1 μg/g) injected immediately before training or after training, or delayed 1 or 4 h, but not 6 h, posttraining. An AP5 10-3 M dose (0.6 μg/g) impairs retention when given before but not after training. Neither antagonist produced retrieval deficit. A memory process similar to CSM but nonassociative in nature and induced by massed training (termed signal memory, SM), proved entirely insensitive to AP5 or MK-801, confirming the view that distinct mechanisms subserve these different types of memory in the crab. © 2002 Elsevier Science Inc. All rights reserved. |
| title |
Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists |
| title_short |
Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists |
| title_full |
Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists |
| title_fullStr |
Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists |
| title_full_unstemmed |
Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists |
| title_sort |
two related forms of memory in the crab chasmagnathus are differentially affected by nmda receptor antagonists |
| publishDate |
2002 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00913057_v72_n1-2_p251_Troncoso http://hdl.handle.net/20.500.12110/paper_00913057_v72_n1-2_p251_Troncoso |
| bdutipo_str |
Repositorios |
| _version_ |
1764820559595569152 |