Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2)
The profile of spontaneous contractions as well as the influences of prostacyclin (PGI2) on the motility of human ovarian veins obtained during the estrogenic phase of the sex cycle were explored. The preparations exhibited a distinct phasic activity, which progressively decreased as isolation time...
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1979
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v18_n6_p829_Borda http://hdl.handle.net/20.500.12110/paper_00906980_v18_n6_p829_Borda |
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paper:paper_00906980_v18_n6_p829_Borda2023-06-08T15:07:52Z Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2) phentolamine propranolol prostacyclin estrus human human cell in vitro study muscle contractility normal human ovarian vein peripheral vascular system venoconstriction Adult Epoprostenol Female Humans Muscle Contraction Ovary Phentolamine Propranolol Prostaglandins Veins The profile of spontaneous contractions as well as the influences of prostacyclin (PGI2) on the motility of human ovarian veins obtained during the estrogenic phase of the sex cycle were explored. The preparations exhibited a distinct phasic activity, which progressively decreased as isolation time progresses, dissapearing almost completely following more than two hours. PGI2 produced a biphasic influence on quiescent preparations. After the threshold is attained lower concentrations caused depression of tone whereas higher ones enhanced the basal tone and induced phasic contractile cycles. Phentolamine reduced markedly the stimulating influence of PGI2 but had no action on the inhibitory effects, whereas propranolol failed to alter either the excitatory or the depressive action. The results suggest a participation of alpha-adrenoceptive-mediated mechanisms in the stimulatory effects of PGI2. On the other hand, PGI2 may be of importance in the regulation of venous flow and the spontaneous or PGI2-induced contractions could play a role in the counter current mechanism between veins and arteries in the ovarian pedicle. © 1980. 1979 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v18_n6_p829_Borda http://hdl.handle.net/20.500.12110/paper_00906980_v18_n6_p829_Borda |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
phentolamine propranolol prostacyclin estrus human human cell in vitro study muscle contractility normal human ovarian vein peripheral vascular system venoconstriction Adult Epoprostenol Female Humans Muscle Contraction Ovary Phentolamine Propranolol Prostaglandins Veins |
| spellingShingle |
phentolamine propranolol prostacyclin estrus human human cell in vitro study muscle contractility normal human ovarian vein peripheral vascular system venoconstriction Adult Epoprostenol Female Humans Muscle Contraction Ovary Phentolamine Propranolol Prostaglandins Veins Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2) |
| topic_facet |
phentolamine propranolol prostacyclin estrus human human cell in vitro study muscle contractility normal human ovarian vein peripheral vascular system venoconstriction Adult Epoprostenol Female Humans Muscle Contraction Ovary Phentolamine Propranolol Prostaglandins Veins |
| description |
The profile of spontaneous contractions as well as the influences of prostacyclin (PGI2) on the motility of human ovarian veins obtained during the estrogenic phase of the sex cycle were explored. The preparations exhibited a distinct phasic activity, which progressively decreased as isolation time progresses, dissapearing almost completely following more than two hours. PGI2 produced a biphasic influence on quiescent preparations. After the threshold is attained lower concentrations caused depression of tone whereas higher ones enhanced the basal tone and induced phasic contractile cycles. Phentolamine reduced markedly the stimulating influence of PGI2 but had no action on the inhibitory effects, whereas propranolol failed to alter either the excitatory or the depressive action. The results suggest a participation of alpha-adrenoceptive-mediated mechanisms in the stimulatory effects of PGI2. On the other hand, PGI2 may be of importance in the regulation of venous flow and the spontaneous or PGI2-induced contractions could play a role in the counter current mechanism between veins and arteries in the ovarian pedicle. © 1980. |
| title |
Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2) |
| title_short |
Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2) |
| title_full |
Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2) |
| title_fullStr |
Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2) |
| title_full_unstemmed |
Spontaneous contractile activity of isolated ovarian human vein. A dual influence of prostacyclin (PGI2) |
| title_sort |
spontaneous contractile activity of isolated ovarian human vein. a dual influence of prostacyclin (pgi2) |
| publishDate |
1979 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v18_n6_p829_Borda http://hdl.handle.net/20.500.12110/paper_00906980_v18_n6_p829_Borda |
| _version_ |
1768544723840008192 |