Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E?
Variations in the spontaneous contractile activity during 6 hours following isolation of uterine horns from proestrus, metestrus and spayed rats, were explored. In estrus and metestrus preparations the contractions declined during 60 min and between 180-200 min a progressive spontaneous recovery (ab...
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1979
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v17_n5_p673_Gimeno http://hdl.handle.net/20.500.12110/paper_00906980_v17_n5_p673_Gimeno |
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paper:paper_00906980_v17_n5_p673_Gimeno2023-06-08T15:07:52Z Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E? indometacin prostaglandin e prostaglandin e2 prostaglandin f2 alpha animal experiment estrus female genital system in vitro study metestrus rat uterus contraction Animals Estrus Female Indomethacin Ovary Pregnancy Prostaglandins E Prostaglandins F Rats Secretory Rate Time Factors Uterine Contraction Variations in the spontaneous contractile activity during 6 hours following isolation of uterine horns from proestrus, metestrus and spayed rats, were explored. In estrus and metestrus preparations the contractions declined during 60 min and between 180-200 min a progressive spontaneous recovery (abolished by indomethacin) was observed up to 360 min. Uteri from proestrus and spayed animals exhibited a continuous depression without recovery during the whole experimental period. At 60 min, uterine horns from estrus animals (which showed a marked contractile decrement) released to the suspending medium significantly less prostaglandin E-like material than at 360 min, i.e. when contractions had almost completely recovered. No modification in the amount of prostaglandin F-like material was detected accompanying these spontaneous contractile variations. In the spayed group at 60 min of functioning (i.e. when the contractile impairment was significantly smaller than at a later time) the release of PGE was greater than at 360 min. These findings suggest a possible control of rat uterine contractions by PGE, rather than by PGF. © 1979. 1979 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v17_n5_p673_Gimeno http://hdl.handle.net/20.500.12110/paper_00906980_v17_n5_p673_Gimeno |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
indometacin prostaglandin e prostaglandin e2 prostaglandin f2 alpha animal experiment estrus female genital system in vitro study metestrus rat uterus contraction Animals Estrus Female Indomethacin Ovary Pregnancy Prostaglandins E Prostaglandins F Rats Secretory Rate Time Factors Uterine Contraction |
| spellingShingle |
indometacin prostaglandin e prostaglandin e2 prostaglandin f2 alpha animal experiment estrus female genital system in vitro study metestrus rat uterus contraction Animals Estrus Female Indomethacin Ovary Pregnancy Prostaglandins E Prostaglandins F Rats Secretory Rate Time Factors Uterine Contraction Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E? |
| topic_facet |
indometacin prostaglandin e prostaglandin e2 prostaglandin f2 alpha animal experiment estrus female genital system in vitro study metestrus rat uterus contraction Animals Estrus Female Indomethacin Ovary Pregnancy Prostaglandins E Prostaglandins F Rats Secretory Rate Time Factors Uterine Contraction |
| description |
Variations in the spontaneous contractile activity during 6 hours following isolation of uterine horns from proestrus, metestrus and spayed rats, were explored. In estrus and metestrus preparations the contractions declined during 60 min and between 180-200 min a progressive spontaneous recovery (abolished by indomethacin) was observed up to 360 min. Uteri from proestrus and spayed animals exhibited a continuous depression without recovery during the whole experimental period. At 60 min, uterine horns from estrus animals (which showed a marked contractile decrement) released to the suspending medium significantly less prostaglandin E-like material than at 360 min, i.e. when contractions had almost completely recovered. No modification in the amount of prostaglandin F-like material was detected accompanying these spontaneous contractile variations. In the spayed group at 60 min of functioning (i.e. when the contractile impairment was significantly smaller than at a later time) the release of PGE was greater than at 360 min. These findings suggest a possible control of rat uterine contractions by PGE, rather than by PGF. © 1979. |
| title |
Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E? |
| title_short |
Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E? |
| title_full |
Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E? |
| title_fullStr |
Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E? |
| title_full_unstemmed |
Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E? |
| title_sort |
is the spontaneous motility of isolated rat uterus controlled by prostaglandin e? |
| publishDate |
1979 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906980_v17_n5_p673_Gimeno http://hdl.handle.net/20.500.12110/paper_00906980_v17_n5_p673_Gimeno |
| _version_ |
1768544587872206848 |