Non-invasive biomechanical evaluation of implanted human cryopreserved arterial homografts : CCCComparison with pre-implanted cryografts and arteries from human donors and recipients
Native vessels-grafts biomechanical mismatch (BM) is related to graft failure. The BM could be reduced using human cryopreserved/defrosted arteries (cryografts), but post-thaw cryografts' recovery could be associated with an impaired biomechanical behavior. In vitro, we demonstrated that our cr...
| Publicado: |
2009
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906964_v37_n7_p1273_Bia http://hdl.handle.net/20.500.12110/paper_00906964_v37_n7_p1273_Bia |
| Aporte de: |
| id |
paper:paper_00906964_v37_n7_p1273_Bia |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_00906964_v37_n7_p1273_Bia2023-06-08T15:07:51Z Non-invasive biomechanical evaluation of implanted human cryopreserved arterial homografts : CCCComparison with pre-implanted cryografts and arteries from human donors and recipients Arterial remodeling Arterial stiffness B-mode echography Biomechanical mismatch Cryopreserved arterial homografts Elasticity Intima-media thickness Non-invasive evaluation Pulse wave velocity Arterial remodeling Arterial stiffness B-mode echography Biomechanical mismatch Cryopreserved arterial homografts Intima-media thickness Non-invasive evaluation Pulse wave velocity Acoustic wave velocity Elasticity Grafts Stiffness Ultrasonic imaging Biomechanics aged artery article biomechanics blood vessel prosthesis clinical trial comparative study computer assisted diagnosis cryopreservation donor echography elastography equipment female human male mechanical stress methodology middle aged pathophysiology physiology transplantation young modulus Aged Arteries Biomechanics Blood Vessel Prosthesis Cryopreservation Elastic Modulus Elasticity Imaging Techniques Equipment Failure Analysis Female Humans Image Interpretation, Computer-Assisted Male Middle Aged Stress, Mechanical Tissue Donors Native vessels-grafts biomechanical mismatch (BM) is related to graft failure. The BM could be reduced using human cryopreserved/defrosted arteries (cryografts), but post-thaw cryografts' recovery could be associated with an impaired biomechanical behavior. In vitro, we demonstrated that our cryopreservation methods do not affect arteries' biomechanics, but only post-implant studies would allow determining the cryografts' biomechanical performance. Aim To characterize the biomechanical properties of implanted cryografts, and to compare them with cryografts pre-implant, recipients' native arteries, and arteries from subjects with characteristics similar to those of the recipients and multiorgan donors (MOD) whose arteries were cryopreserved. Methods Native femoral arteries anastomosed to cryografts, implanted cryografts, and arteries from subjects, recipient-like and MOD-like, were studied. In vitro (pre-implant cryografts) and in vivo non-invasive studies were performed. Arterial pressure, diameter, and wall thickness were obtained to quantify local and regional biomechanical parameters, and to evaluate the arterial remodeling. Conclusion Implanted cryografts were remodeled, with an increased wall thickness, wall-to-lumen ratio, and wall cross-sectional area. The proximal-distal gradual transition in stiffness remained unchanged. Implanted cryografts were stiffer than MOD-like arteries, but more compliant than recipients' arteries. The cryografts-native arteries biomechanical differences were lesser than those described for venous grafts or expanded polytetrafluoroethylene. © 2009 Biomedical Engineering Society. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906964_v37_n7_p1273_Bia http://hdl.handle.net/20.500.12110/paper_00906964_v37_n7_p1273_Bia |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Arterial remodeling Arterial stiffness B-mode echography Biomechanical mismatch Cryopreserved arterial homografts Elasticity Intima-media thickness Non-invasive evaluation Pulse wave velocity Arterial remodeling Arterial stiffness B-mode echography Biomechanical mismatch Cryopreserved arterial homografts Intima-media thickness Non-invasive evaluation Pulse wave velocity Acoustic wave velocity Elasticity Grafts Stiffness Ultrasonic imaging Biomechanics aged artery article biomechanics blood vessel prosthesis clinical trial comparative study computer assisted diagnosis cryopreservation donor echography elastography equipment female human male mechanical stress methodology middle aged pathophysiology physiology transplantation young modulus Aged Arteries Biomechanics Blood Vessel Prosthesis Cryopreservation Elastic Modulus Elasticity Imaging Techniques Equipment Failure Analysis Female Humans Image Interpretation, Computer-Assisted Male Middle Aged Stress, Mechanical Tissue Donors |
| spellingShingle |
Arterial remodeling Arterial stiffness B-mode echography Biomechanical mismatch Cryopreserved arterial homografts Elasticity Intima-media thickness Non-invasive evaluation Pulse wave velocity Arterial remodeling Arterial stiffness B-mode echography Biomechanical mismatch Cryopreserved arterial homografts Intima-media thickness Non-invasive evaluation Pulse wave velocity Acoustic wave velocity Elasticity Grafts Stiffness Ultrasonic imaging Biomechanics aged artery article biomechanics blood vessel prosthesis clinical trial comparative study computer assisted diagnosis cryopreservation donor echography elastography equipment female human male mechanical stress methodology middle aged pathophysiology physiology transplantation young modulus Aged Arteries Biomechanics Blood Vessel Prosthesis Cryopreservation Elastic Modulus Elasticity Imaging Techniques Equipment Failure Analysis Female Humans Image Interpretation, Computer-Assisted Male Middle Aged Stress, Mechanical Tissue Donors Non-invasive biomechanical evaluation of implanted human cryopreserved arterial homografts : CCCComparison with pre-implanted cryografts and arteries from human donors and recipients |
| topic_facet |
Arterial remodeling Arterial stiffness B-mode echography Biomechanical mismatch Cryopreserved arterial homografts Elasticity Intima-media thickness Non-invasive evaluation Pulse wave velocity Arterial remodeling Arterial stiffness B-mode echography Biomechanical mismatch Cryopreserved arterial homografts Intima-media thickness Non-invasive evaluation Pulse wave velocity Acoustic wave velocity Elasticity Grafts Stiffness Ultrasonic imaging Biomechanics aged artery article biomechanics blood vessel prosthesis clinical trial comparative study computer assisted diagnosis cryopreservation donor echography elastography equipment female human male mechanical stress methodology middle aged pathophysiology physiology transplantation young modulus Aged Arteries Biomechanics Blood Vessel Prosthesis Cryopreservation Elastic Modulus Elasticity Imaging Techniques Equipment Failure Analysis Female Humans Image Interpretation, Computer-Assisted Male Middle Aged Stress, Mechanical Tissue Donors |
| description |
Native vessels-grafts biomechanical mismatch (BM) is related to graft failure. The BM could be reduced using human cryopreserved/defrosted arteries (cryografts), but post-thaw cryografts' recovery could be associated with an impaired biomechanical behavior. In vitro, we demonstrated that our cryopreservation methods do not affect arteries' biomechanics, but only post-implant studies would allow determining the cryografts' biomechanical performance. Aim To characterize the biomechanical properties of implanted cryografts, and to compare them with cryografts pre-implant, recipients' native arteries, and arteries from subjects with characteristics similar to those of the recipients and multiorgan donors (MOD) whose arteries were cryopreserved. Methods Native femoral arteries anastomosed to cryografts, implanted cryografts, and arteries from subjects, recipient-like and MOD-like, were studied. In vitro (pre-implant cryografts) and in vivo non-invasive studies were performed. Arterial pressure, diameter, and wall thickness were obtained to quantify local and regional biomechanical parameters, and to evaluate the arterial remodeling. Conclusion Implanted cryografts were remodeled, with an increased wall thickness, wall-to-lumen ratio, and wall cross-sectional area. The proximal-distal gradual transition in stiffness remained unchanged. Implanted cryografts were stiffer than MOD-like arteries, but more compliant than recipients' arteries. The cryografts-native arteries biomechanical differences were lesser than those described for venous grafts or expanded polytetrafluoroethylene. © 2009 Biomedical Engineering Society. |
| title |
Non-invasive biomechanical evaluation of implanted human cryopreserved arterial homografts : CCCComparison with pre-implanted cryografts and arteries from human donors and recipients |
| title_short |
Non-invasive biomechanical evaluation of implanted human cryopreserved arterial homografts : CCCComparison with pre-implanted cryografts and arteries from human donors and recipients |
| title_full |
Non-invasive biomechanical evaluation of implanted human cryopreserved arterial homografts : CCCComparison with pre-implanted cryografts and arteries from human donors and recipients |
| title_fullStr |
Non-invasive biomechanical evaluation of implanted human cryopreserved arterial homografts : CCCComparison with pre-implanted cryografts and arteries from human donors and recipients |
| title_full_unstemmed |
Non-invasive biomechanical evaluation of implanted human cryopreserved arterial homografts : CCCComparison with pre-implanted cryografts and arteries from human donors and recipients |
| title_sort |
non-invasive biomechanical evaluation of implanted human cryopreserved arterial homografts : ccccomparison with pre-implanted cryografts and arteries from human donors and recipients |
| publishDate |
2009 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00906964_v37_n7_p1273_Bia http://hdl.handle.net/20.500.12110/paper_00906964_v37_n7_p1273_Bia |
| _version_ |
1768545919582601216 |