VIP and tolerance induction in autoimmunity

Vasoactive intestinal peptide (VIP) is a potent antiinflammatory agent with immunoregulatory properties, skewing the immune response to a Th2 pattern of cytokine production. Here, we studied the effect of treatment with VIP in the development of diabetes in nonobese diabetic (NOD) mice, an annual mo...

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Autores principales:	Rosignoli, Florencia, Pérez Leirós, Claudia
Publicado:	2006
Materias:	Autoimmune FoxP3 TGF-β VIP cytokine transcription factor transcription factor T bet transforming growth factor beta vasoactive intestinal polypeptide animal experiment animal model autoimmunity cell differentiation cell function conference paper controlled study down regulation drug mechanism female insulin dependent diabetes mellitus insulitis mouse nonhuman pancreas pancreas islet regulatory T lymphocyte Th1 cell upregulation Animalia
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v1070_n_p525_Rosignoli http://hdl.handle.net/20.500.12110/paper_00778923_v1070_n_p525_Rosignoli
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00778923_v1070_n_p525_Rosignoli
record_format	dspace
spelling	paper:paper_00778923_v1070_n_p525_Rosignoli2023-06-08T15:07:27Z VIP and tolerance induction in autoimmunity Rosignoli, Florencia Pérez Leirós, Claudia Autoimmune FoxP3 TGF-β VIP cytokine transcription factor transcription factor T bet transforming growth factor beta vasoactive intestinal polypeptide animal experiment animal model autoimmunity cell differentiation cell function conference paper controlled study down regulation drug mechanism female insulin dependent diabetes mellitus insulitis mouse nonhuman pancreas pancreas islet regulatory T lymphocyte Th1 cell upregulation Animalia Vasoactive intestinal peptide (VIP) is a potent antiinflammatory agent with immunoregulatory properties, skewing the immune response to a Th2 pattern of cytokine production. Here, we studied the effect of treatment with VIP in the development of diabetes in nonobese diabetic (NOD) mice, an annual model of type 1 diabetes. Mice treated with VIP from 4 weeks of age did not develop diabetes and showed milder insulitis than nontreated mice. The protective mechanism of VIP was associated with a reduction in the circulating levels of Th1 cytokines. In the pancreas of VIP-treated animals, regulatory T cell markers predominate, as indicated by the upregulation of FoxP3 and transforming growth factor-β (TGF-β), and the downregulation of the transcription factor, T-bet. These findings indicate that VIP restores tolerance to pancreatic islets by promoting the local differentiation and function of regulatory T cells. © 2006 New York Academy of Sciences. Fil:Rosignoli, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pérez-Leirós, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2006 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v1070_n_p525_Rosignoli http://hdl.handle.net/20.500.12110/paper_00778923_v1070_n_p525_Rosignoli
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Autoimmune FoxP3 TGF-β VIP cytokine transcription factor transcription factor T bet transforming growth factor beta vasoactive intestinal polypeptide animal experiment animal model autoimmunity cell differentiation cell function conference paper controlled study down regulation drug mechanism female insulin dependent diabetes mellitus insulitis mouse nonhuman pancreas pancreas islet regulatory T lymphocyte Th1 cell upregulation Animalia
spellingShingle	Autoimmune FoxP3 TGF-β VIP cytokine transcription factor transcription factor T bet transforming growth factor beta vasoactive intestinal polypeptide animal experiment animal model autoimmunity cell differentiation cell function conference paper controlled study down regulation drug mechanism female insulin dependent diabetes mellitus insulitis mouse nonhuman pancreas pancreas islet regulatory T lymphocyte Th1 cell upregulation Animalia Rosignoli, Florencia Pérez Leirós, Claudia VIP and tolerance induction in autoimmunity
topic_facet	Autoimmune FoxP3 TGF-β VIP cytokine transcription factor transcription factor T bet transforming growth factor beta vasoactive intestinal polypeptide animal experiment animal model autoimmunity cell differentiation cell function conference paper controlled study down regulation drug mechanism female insulin dependent diabetes mellitus insulitis mouse nonhuman pancreas pancreas islet regulatory T lymphocyte Th1 cell upregulation Animalia
description	Vasoactive intestinal peptide (VIP) is a potent antiinflammatory agent with immunoregulatory properties, skewing the immune response to a Th2 pattern of cytokine production. Here, we studied the effect of treatment with VIP in the development of diabetes in nonobese diabetic (NOD) mice, an annual model of type 1 diabetes. Mice treated with VIP from 4 weeks of age did not develop diabetes and showed milder insulitis than nontreated mice. The protective mechanism of VIP was associated with a reduction in the circulating levels of Th1 cytokines. In the pancreas of VIP-treated animals, regulatory T cell markers predominate, as indicated by the upregulation of FoxP3 and transforming growth factor-β (TGF-β), and the downregulation of the transcription factor, T-bet. These findings indicate that VIP restores tolerance to pancreatic islets by promoting the local differentiation and function of regulatory T cells. © 2006 New York Academy of Sciences.
author	Rosignoli, Florencia Pérez Leirós, Claudia
author_facet	Rosignoli, Florencia Pérez Leirós, Claudia
author_sort	Rosignoli, Florencia
title	VIP and tolerance induction in autoimmunity
title_short	VIP and tolerance induction in autoimmunity
title_full	VIP and tolerance induction in autoimmunity
title_fullStr	VIP and tolerance induction in autoimmunity
title_full_unstemmed	VIP and tolerance induction in autoimmunity
title_sort	vip and tolerance induction in autoimmunity
publishDate	2006
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00778923_v1070_n_p525_Rosignoli http://hdl.handle.net/20.500.12110/paper_00778923_v1070_n_p525_Rosignoli
work_keys_str_mv	AT rosignoliflorencia vipandtoleranceinductioninautoimmunity AT perezleirosclaudia vipandtoleranceinductioninautoimmunity
_version_	1768544311222206464

VIP and tolerance induction in autoimmunity

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