In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions
It was found that concentrated polyethylene glycol 400 (PEG 400) solutions have significant antibacterial activity against various pathogenic bacteria, including Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus. This effect might be attributed to two effects...
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1983
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00664804_v24_n3_p409_Chirife http://hdl.handle.net/20.500.12110/paper_00664804_v24_n3_p409_Chirife |
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paper:paper_00664804_v24_n3_p409_Chirife2023-06-08T15:06:09Z In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions macrogol 400 drug sensitivity Escherichia coli in vitro study Klebsiella Klebsiella pneumoniae nonhuman phase contrast microscopy Pseudomonas Pseudomonas aeruginosa Staphylococcus Staphylococcus aureus It was found that concentrated polyethylene glycol 400 (PEG 400) solutions have significant antibacterial activity against various pathogenic bacteria, including Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus. This effect might be attributed to two effects: lowering of water activity and, superimposed on this, the specific action of PEG-400 molecules on bacterial cells. Phase-contrast microscopic observations of cells placed in contact with PEG 400 revealed clumping and morphological changes of bacterial cells. The larger changes in appearances were evidenced by the species which were more rapidly killed by PEG 400. The results obtained suggested that concentrated PEG 400 solutions may have a potential value in medicine as a topical antibacterial agent. The feasibility of this application is the subject of present investigation. 1983 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00664804_v24_n3_p409_Chirife http://hdl.handle.net/20.500.12110/paper_00664804_v24_n3_p409_Chirife |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
macrogol 400 drug sensitivity Escherichia coli in vitro study Klebsiella Klebsiella pneumoniae nonhuman phase contrast microscopy Pseudomonas Pseudomonas aeruginosa Staphylococcus Staphylococcus aureus |
| spellingShingle |
macrogol 400 drug sensitivity Escherichia coli in vitro study Klebsiella Klebsiella pneumoniae nonhuman phase contrast microscopy Pseudomonas Pseudomonas aeruginosa Staphylococcus Staphylococcus aureus In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions |
| topic_facet |
macrogol 400 drug sensitivity Escherichia coli in vitro study Klebsiella Klebsiella pneumoniae nonhuman phase contrast microscopy Pseudomonas Pseudomonas aeruginosa Staphylococcus Staphylococcus aureus |
| description |
It was found that concentrated polyethylene glycol 400 (PEG 400) solutions have significant antibacterial activity against various pathogenic bacteria, including Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus. This effect might be attributed to two effects: lowering of water activity and, superimposed on this, the specific action of PEG-400 molecules on bacterial cells. Phase-contrast microscopic observations of cells placed in contact with PEG 400 revealed clumping and morphological changes of bacterial cells. The larger changes in appearances were evidenced by the species which were more rapidly killed by PEG 400. The results obtained suggested that concentrated PEG 400 solutions may have a potential value in medicine as a topical antibacterial agent. The feasibility of this application is the subject of present investigation. |
| title |
In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions |
| title_short |
In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions |
| title_full |
In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions |
| title_fullStr |
In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions |
| title_full_unstemmed |
In vitro antibacterial activity of concentrated polyethylene glycol 400 solutions |
| title_sort |
in vitro antibacterial activity of concentrated polyethylene glycol 400 solutions |
| publishDate |
1983 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00664804_v24_n3_p409_Chirife http://hdl.handle.net/20.500.12110/paper_00664804_v24_n3_p409_Chirife |
| _version_ |
1768546061419282432 |