Plasmatic homocysteine response to vitamin supplementation in elderly people
Homocysteine (Hcy) increase is now widely accepted as a risk factor for vascular disease. The effects of folic acid (FA) and vitamins B12 and B6 in lowering Hcy have been extensively studied, but there is still little data on the response to FA dietary administration. Our purpose was to evaluate the...
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2000
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00493848_v100_n6_p495_Murua http://hdl.handle.net/20.500.12110/paper_00493848_v100_n6_p495_Murua |
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paper:paper_00493848_v100_n6_p495_Murua2023-06-08T15:05:46Z Plasmatic homocysteine response to vitamin supplementation in elderly people Diet Elderly Folic acid Homocysteine Vitamin treatment folic acid homocysteine vitamin article atherogenesis atherosclerosis cardiovascular risk clinical article clinical trial controlled clinical trial controlled study diet supplementation drug effect elderly care female human male priority journal randomized controlled trial risk factor single blind procedure thrombogenesis thrombosis vascular disease vitamin supplementation Aged Aged, 80 and over Dietary Supplements Dose-Response Relationship, Drug Female Folic Acid Homocysteine Humans Male Statistics, Nonparametric Vascular Diseases Vitamins Homocysteine (Hcy) increase is now widely accepted as a risk factor for vascular disease. The effects of folic acid (FA) and vitamins B12 and B6 in lowering Hcy have been extensively studied, but there is still little data on the response to FA dietary administration. Our purpose was to evaluate the impact of the diet and the degree of response to different doses of pharmacological FA supplementation. In a prospective, randomized, and simple blind study, 50 elderly subjects were given a 400-μg/day FA diet and were randomly assigned to one of the following treatments: Group I=placebo tablet; Group II=tablet containing 1-mg folic acid, 1-mg B12, and 25-mg B6; and Group III=tablet containing 2.5-mg folic acid and same B6 and B12 doses as Group II. Forty-four subjects completed the study, and their plasmas were evaluated. Hcy concentration significantly decreased even in patients with normal basal values, and there were no differences in the response between individuals receiving diet plus placebo and those receiving diet plus pharmacological supplementation. After the treatment, the mean decrease of plasmatic Hcy levels was 10.8 (9.4, 12.5) μmol/l, geometric mean [95% confidence interval (95% CI)], and particularly, the values for Group I were 10.6 (7.4, 14.8) μmol/l. In 31% of the subjects, the post-treatment Hcy levels were ≤5 μmol/l. These results show that a special diet, with or without pharmacological FA and B12 and B6 supplementation, significantly decreases the Hcy levels in elderly people. Therefore, a diet with high contents of FA might have an enormous impact on the morbidity and mortality of atherothrombosis. © 2000 Elsevier Science Ltd. 2000 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00493848_v100_n6_p495_Murua http://hdl.handle.net/20.500.12110/paper_00493848_v100_n6_p495_Murua |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Diet Elderly Folic acid Homocysteine Vitamin treatment folic acid homocysteine vitamin article atherogenesis atherosclerosis cardiovascular risk clinical article clinical trial controlled clinical trial controlled study diet supplementation drug effect elderly care female human male priority journal randomized controlled trial risk factor single blind procedure thrombogenesis thrombosis vascular disease vitamin supplementation Aged Aged, 80 and over Dietary Supplements Dose-Response Relationship, Drug Female Folic Acid Homocysteine Humans Male Statistics, Nonparametric Vascular Diseases Vitamins |
| spellingShingle |
Diet Elderly Folic acid Homocysteine Vitamin treatment folic acid homocysteine vitamin article atherogenesis atherosclerosis cardiovascular risk clinical article clinical trial controlled clinical trial controlled study diet supplementation drug effect elderly care female human male priority journal randomized controlled trial risk factor single blind procedure thrombogenesis thrombosis vascular disease vitamin supplementation Aged Aged, 80 and over Dietary Supplements Dose-Response Relationship, Drug Female Folic Acid Homocysteine Humans Male Statistics, Nonparametric Vascular Diseases Vitamins Plasmatic homocysteine response to vitamin supplementation in elderly people |
| topic_facet |
Diet Elderly Folic acid Homocysteine Vitamin treatment folic acid homocysteine vitamin article atherogenesis atherosclerosis cardiovascular risk clinical article clinical trial controlled clinical trial controlled study diet supplementation drug effect elderly care female human male priority journal randomized controlled trial risk factor single blind procedure thrombogenesis thrombosis vascular disease vitamin supplementation Aged Aged, 80 and over Dietary Supplements Dose-Response Relationship, Drug Female Folic Acid Homocysteine Humans Male Statistics, Nonparametric Vascular Diseases Vitamins |
| description |
Homocysteine (Hcy) increase is now widely accepted as a risk factor for vascular disease. The effects of folic acid (FA) and vitamins B12 and B6 in lowering Hcy have been extensively studied, but there is still little data on the response to FA dietary administration. Our purpose was to evaluate the impact of the diet and the degree of response to different doses of pharmacological FA supplementation. In a prospective, randomized, and simple blind study, 50 elderly subjects were given a 400-μg/day FA diet and were randomly assigned to one of the following treatments: Group I=placebo tablet; Group II=tablet containing 1-mg folic acid, 1-mg B12, and 25-mg B6; and Group III=tablet containing 2.5-mg folic acid and same B6 and B12 doses as Group II. Forty-four subjects completed the study, and their plasmas were evaluated. Hcy concentration significantly decreased even in patients with normal basal values, and there were no differences in the response between individuals receiving diet plus placebo and those receiving diet plus pharmacological supplementation. After the treatment, the mean decrease of plasmatic Hcy levels was 10.8 (9.4, 12.5) μmol/l, geometric mean [95% confidence interval (95% CI)], and particularly, the values for Group I were 10.6 (7.4, 14.8) μmol/l. In 31% of the subjects, the post-treatment Hcy levels were ≤5 μmol/l. These results show that a special diet, with or without pharmacological FA and B12 and B6 supplementation, significantly decreases the Hcy levels in elderly people. Therefore, a diet with high contents of FA might have an enormous impact on the morbidity and mortality of atherothrombosis. © 2000 Elsevier Science Ltd. |
| title |
Plasmatic homocysteine response to vitamin supplementation in elderly people |
| title_short |
Plasmatic homocysteine response to vitamin supplementation in elderly people |
| title_full |
Plasmatic homocysteine response to vitamin supplementation in elderly people |
| title_fullStr |
Plasmatic homocysteine response to vitamin supplementation in elderly people |
| title_full_unstemmed |
Plasmatic homocysteine response to vitamin supplementation in elderly people |
| title_sort |
plasmatic homocysteine response to vitamin supplementation in elderly people |
| publishDate |
2000 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00493848_v100_n6_p495_Murua http://hdl.handle.net/20.500.12110/paper_00493848_v100_n6_p495_Murua |
| _version_ |
1768544949960179712 |