Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance
The impact of interstitial inflammatory cells, such as mast cells, and angiogenesis on the prognosis of cancer patients has been reported in many solid tumors, although there is disagreement about their role. We undertook a retrospective study with tissue samples from 65 patients with stage I and II...
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paper:paper_00468177_v41_n5_p697_Carlini2023-06-08T15:05:32Z Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance Puricelli, Lydia Inés Lauria de Cidre, Lilia Intratumoral Lung cancer Mast cell phenotypes Microvessels Peritumoral CD34 antigen chymase tryptase adult aged article cancer survival cell infiltration controlled study female human human tissue immunohistochemistry lung lobectomy lung non small cell cancer major clinical study male mast cell microvasculature phenotype prognosis Age Factors Aged Aged, 80 and over Carcinoma, Non-Small-Cell Lung Chi-Square Distribution Female Humans Immunohistochemistry Lung Lung Neoplasms Male Mast Cells Microvessels Middle Aged Neoplasm Staging Neovascularization, Pathologic Prognosis Proportional Hazards Models Retrospective Studies Statistics, Nonparametric The impact of interstitial inflammatory cells, such as mast cells, and angiogenesis on the prognosis of cancer patients has been reported in many solid tumors, although there is disagreement about their role. We undertook a retrospective study with tissue samples from 65 patients with stage I and II non-small cell lung cancer to assess the clinical pathologic role and prognostic significance of mast cells. Mast cell phenotypes were identified by immunohistochemistry for tryptase and chymase. In addition, we identified microvessels using the endothelial marker CD34. Mast cell and microvessel density was quantified by assessing immunopositive cells in the intratumoral and peritumoral zones of tumor specimens. Both mast cell and microvessel density was higher in the peritumoral zone than the intratumoral zone (P ≤ .05). A positive correlation between mast cell (tryptase-chymase phenotype) and microvessel densities was observed in the intratumoral zone (P ≤ .05), supporting the involvement of mast cells in the angiogenic process. Regarding survival, a subset of stage I patients had a worse prognosis at five years when low mast cell (tryptase-chymase phenotype) density was found in the peritumoral zone (median survival in months [range]: 27 [1-60] versus 46 [1-60]). Multivariate Cox analysis indicated that this parameter may be an independent prognostic factor (P ≤ .05) useful for selecting candidates for earlier treatment. © 2010 Elsevier Inc. All rights reserved. Fil:Puricelli, L.I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Lauría de Cidre, L.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00468177_v41_n5_p697_Carlini http://hdl.handle.net/20.500.12110/paper_00468177_v41_n5_p697_Carlini |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Intratumoral Lung cancer Mast cell phenotypes Microvessels Peritumoral CD34 antigen chymase tryptase adult aged article cancer survival cell infiltration controlled study female human human tissue immunohistochemistry lung lobectomy lung non small cell cancer major clinical study male mast cell microvasculature phenotype prognosis Age Factors Aged Aged, 80 and over Carcinoma, Non-Small-Cell Lung Chi-Square Distribution Female Humans Immunohistochemistry Lung Lung Neoplasms Male Mast Cells Microvessels Middle Aged Neoplasm Staging Neovascularization, Pathologic Prognosis Proportional Hazards Models Retrospective Studies Statistics, Nonparametric |
| spellingShingle |
Intratumoral Lung cancer Mast cell phenotypes Microvessels Peritumoral CD34 antigen chymase tryptase adult aged article cancer survival cell infiltration controlled study female human human tissue immunohistochemistry lung lobectomy lung non small cell cancer major clinical study male mast cell microvasculature phenotype prognosis Age Factors Aged Aged, 80 and over Carcinoma, Non-Small-Cell Lung Chi-Square Distribution Female Humans Immunohistochemistry Lung Lung Neoplasms Male Mast Cells Microvessels Middle Aged Neoplasm Staging Neovascularization, Pathologic Prognosis Proportional Hazards Models Retrospective Studies Statistics, Nonparametric Puricelli, Lydia Inés Lauria de Cidre, Lilia Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance |
| topic_facet |
Intratumoral Lung cancer Mast cell phenotypes Microvessels Peritumoral CD34 antigen chymase tryptase adult aged article cancer survival cell infiltration controlled study female human human tissue immunohistochemistry lung lobectomy lung non small cell cancer major clinical study male mast cell microvasculature phenotype prognosis Age Factors Aged Aged, 80 and over Carcinoma, Non-Small-Cell Lung Chi-Square Distribution Female Humans Immunohistochemistry Lung Lung Neoplasms Male Mast Cells Microvessels Middle Aged Neoplasm Staging Neovascularization, Pathologic Prognosis Proportional Hazards Models Retrospective Studies Statistics, Nonparametric |
| description |
The impact of interstitial inflammatory cells, such as mast cells, and angiogenesis on the prognosis of cancer patients has been reported in many solid tumors, although there is disagreement about their role. We undertook a retrospective study with tissue samples from 65 patients with stage I and II non-small cell lung cancer to assess the clinical pathologic role and prognostic significance of mast cells. Mast cell phenotypes were identified by immunohistochemistry for tryptase and chymase. In addition, we identified microvessels using the endothelial marker CD34. Mast cell and microvessel density was quantified by assessing immunopositive cells in the intratumoral and peritumoral zones of tumor specimens. Both mast cell and microvessel density was higher in the peritumoral zone than the intratumoral zone (P ≤ .05). A positive correlation between mast cell (tryptase-chymase phenotype) and microvessel densities was observed in the intratumoral zone (P ≤ .05), supporting the involvement of mast cells in the angiogenic process. Regarding survival, a subset of stage I patients had a worse prognosis at five years when low mast cell (tryptase-chymase phenotype) density was found in the peritumoral zone (median survival in months [range]: 27 [1-60] versus 46 [1-60]). Multivariate Cox analysis indicated that this parameter may be an independent prognostic factor (P ≤ .05) useful for selecting candidates for earlier treatment. © 2010 Elsevier Inc. All rights reserved. |
| author |
Puricelli, Lydia Inés Lauria de Cidre, Lilia |
| author_facet |
Puricelli, Lydia Inés Lauria de Cidre, Lilia |
| author_sort |
Puricelli, Lydia Inés |
| title |
Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance |
| title_short |
Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance |
| title_full |
Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance |
| title_fullStr |
Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance |
| title_full_unstemmed |
Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance |
| title_sort |
mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance |
| publishDate |
2010 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00468177_v41_n5_p697_Carlini http://hdl.handle.net/20.500.12110/paper_00468177_v41_n5_p697_Carlini |
| work_keys_str_mv |
AT puricellilydiaines mastcellphenotypesandmicrovesselsinnonsmallcelllungcanceranditsprognosticsignificance AT lauriadecidrelilia mastcellphenotypesandmicrovesselsinnonsmallcelllungcanceranditsprognosticsignificance |
| _version_ |
1768544997322260480 |