Effects of three veterinary antibiotics and their binary mixtures on two green alga species

The individual and combined toxicities of chlortetracycline (CTC), oxytetracycline (OTC) and enrofloxacin (ENF) have been examined in two green algae representative of the freshwater environment, the international standard strain Pseudokichneriella subcapitata and the native strain Ankistrodesmus fu...

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Publicado:	2018
Materias:	Binary mixtures Chlortetracycline Enrofloxacin Oxytetracycline Pseudokirchneriella subcapitata Algae Antibiotics Toxicity Concentration addition Freshwater environments International standards Oxytetracyclines (OTC) Toxicological effects antibiotic agent chlortetracycline enrofloxacin oxytetracycline veterinary drug antiinfective agent quinolone derivative antibiotics concentration (composition) experimental study freshwater environment green alga isolated population river pollution toxicity algal growth Ankistrodesmus fusiformis Article Chlorella pyrenoidosa Chlorella vulgaris concentration (parameters) Desmodesmus subspicatus EC50 ecotoxicity ecotoxicology IC50 nonhuman Pseudokichneriella subcapitata river sea pollution drug effects drug interaction limnology algae Chlorophyta Selenastrum capricornutum Anti-Bacterial Agents Drug Interactions Fluoroquinolones Freshwater Biology Veterinary Drugs
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00456535_v194_n_p821_Carusso http://hdl.handle.net/20.500.12110/paper_00456535_v194_n_p821_Carusso
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00456535_v194_n_p821_Carusso
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spelling	paper:paper_00456535_v194_n_p821_Carusso2023-06-08T15:05:16Z Effects of three veterinary antibiotics and their binary mixtures on two green alga species Binary mixtures Chlortetracycline Enrofloxacin Oxytetracycline Pseudokirchneriella subcapitata Algae Antibiotics Toxicity Chlortetracycline Concentration addition Enrofloxacin Freshwater environments International standards Oxytetracyclines (OTC) Pseudokirchneriella subcapitata Toxicological effects Binary mixtures antibiotic agent chlortetracycline enrofloxacin oxytetracycline veterinary drug antiinfective agent chlortetracycline enrofloxacin oxytetracycline quinolone derivative veterinary drug antibiotics concentration (composition) experimental study freshwater environment green alga isolated population river pollution toxicity algal growth Ankistrodesmus fusiformis Article Chlorella pyrenoidosa Chlorella vulgaris concentration (parameters) Desmodesmus subspicatus EC50 ecotoxicity ecotoxicology freshwater environment green alga IC50 nonhuman Pseudokichneriella subcapitata river sea pollution drug effects drug interaction green alga limnology algae Ankistrodesmus fusiformis Chlorophyta Selenastrum capricornutum Anti-Bacterial Agents Chlorophyta Chlortetracycline Drug Interactions Fluoroquinolones Freshwater Biology Oxytetracycline Veterinary Drugs The individual and combined toxicities of chlortetracycline (CTC), oxytetracycline (OTC) and enrofloxacin (ENF) have been examined in two green algae representative of the freshwater environment, the international standard strain Pseudokichneriella subcapitata and the native strain Ankistrodesmus fusiformis. The toxicities of the three antibiotics and their mixtures were similar in both strains, although low concentrations of ENF and CTC + ENF were more toxic in A. fusiformis than in the standard strain. The toxicological interactions of binary mixtures were predicted using the two classical models of additivity: Concentration Addition (CA) and Independent Action (IA), and compared to the experimentally determined toxicities over a range of concentrations between 0.1 and 10 mg L−1. The CA model predicted the inhibition of algal growth in the three mixtures in P. subcapitata, and in the CTC + OTC and CTC + ENF mixtures in A. fusiformis. However, this model underestimated the experimental results obtained in the OTC + ENF mixture in A. fusiformis. The IA model did not predict the experimental toxicological effects of the three mixtures in either strain. The sum of the toxic units (TU) for the mixtures was calculated. According to these values, the binary mixtures CTC + ENF and OTC + ENF showed an additive effect, and the CTC + OTC mixture showed antagonism in P. subcapitata, whereas the three mixtures showed synergistic effects in A. fusiformis. Although A. fusiformis was isolated from a polluted river, it showed a similar sensitivity with respect to P. subcapitata when it was exposed to binary mixtures of antibiotics. © 2017 Elsevier Ltd 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00456535_v194_n_p821_Carusso http://hdl.handle.net/20.500.12110/paper_00456535_v194_n_p821_Carusso
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Binary mixtures Chlortetracycline Enrofloxacin Oxytetracycline Pseudokirchneriella subcapitata Algae Antibiotics Toxicity Chlortetracycline Concentration addition Enrofloxacin Freshwater environments International standards Oxytetracyclines (OTC) Pseudokirchneriella subcapitata Toxicological effects Binary mixtures antibiotic agent chlortetracycline enrofloxacin oxytetracycline veterinary drug antiinfective agent chlortetracycline enrofloxacin oxytetracycline quinolone derivative veterinary drug antibiotics concentration (composition) experimental study freshwater environment green alga isolated population river pollution toxicity algal growth Ankistrodesmus fusiformis Article Chlorella pyrenoidosa Chlorella vulgaris concentration (parameters) Desmodesmus subspicatus EC50 ecotoxicity ecotoxicology freshwater environment green alga IC50 nonhuman Pseudokichneriella subcapitata river sea pollution drug effects drug interaction green alga limnology algae Ankistrodesmus fusiformis Chlorophyta Selenastrum capricornutum Anti-Bacterial Agents Chlorophyta Chlortetracycline Drug Interactions Fluoroquinolones Freshwater Biology Oxytetracycline Veterinary Drugs
spellingShingle	Binary mixtures Chlortetracycline Enrofloxacin Oxytetracycline Pseudokirchneriella subcapitata Algae Antibiotics Toxicity Chlortetracycline Concentration addition Enrofloxacin Freshwater environments International standards Oxytetracyclines (OTC) Pseudokirchneriella subcapitata Toxicological effects Binary mixtures antibiotic agent chlortetracycline enrofloxacin oxytetracycline veterinary drug antiinfective agent chlortetracycline enrofloxacin oxytetracycline quinolone derivative veterinary drug antibiotics concentration (composition) experimental study freshwater environment green alga isolated population river pollution toxicity algal growth Ankistrodesmus fusiformis Article Chlorella pyrenoidosa Chlorella vulgaris concentration (parameters) Desmodesmus subspicatus EC50 ecotoxicity ecotoxicology freshwater environment green alga IC50 nonhuman Pseudokichneriella subcapitata river sea pollution drug effects drug interaction green alga limnology algae Ankistrodesmus fusiformis Chlorophyta Selenastrum capricornutum Anti-Bacterial Agents Chlorophyta Chlortetracycline Drug Interactions Fluoroquinolones Freshwater Biology Oxytetracycline Veterinary Drugs Effects of three veterinary antibiotics and their binary mixtures on two green alga species
topic_facet	Binary mixtures Chlortetracycline Enrofloxacin Oxytetracycline Pseudokirchneriella subcapitata Algae Antibiotics Toxicity Chlortetracycline Concentration addition Enrofloxacin Freshwater environments International standards Oxytetracyclines (OTC) Pseudokirchneriella subcapitata Toxicological effects Binary mixtures antibiotic agent chlortetracycline enrofloxacin oxytetracycline veterinary drug antiinfective agent chlortetracycline enrofloxacin oxytetracycline quinolone derivative veterinary drug antibiotics concentration (composition) experimental study freshwater environment green alga isolated population river pollution toxicity algal growth Ankistrodesmus fusiformis Article Chlorella pyrenoidosa Chlorella vulgaris concentration (parameters) Desmodesmus subspicatus EC50 ecotoxicity ecotoxicology freshwater environment green alga IC50 nonhuman Pseudokichneriella subcapitata river sea pollution drug effects drug interaction green alga limnology algae Ankistrodesmus fusiformis Chlorophyta Selenastrum capricornutum Anti-Bacterial Agents Chlorophyta Chlortetracycline Drug Interactions Fluoroquinolones Freshwater Biology Oxytetracycline Veterinary Drugs
description	The individual and combined toxicities of chlortetracycline (CTC), oxytetracycline (OTC) and enrofloxacin (ENF) have been examined in two green algae representative of the freshwater environment, the international standard strain Pseudokichneriella subcapitata and the native strain Ankistrodesmus fusiformis. The toxicities of the three antibiotics and their mixtures were similar in both strains, although low concentrations of ENF and CTC + ENF were more toxic in A. fusiformis than in the standard strain. The toxicological interactions of binary mixtures were predicted using the two classical models of additivity: Concentration Addition (CA) and Independent Action (IA), and compared to the experimentally determined toxicities over a range of concentrations between 0.1 and 10 mg L−1. The CA model predicted the inhibition of algal growth in the three mixtures in P. subcapitata, and in the CTC + OTC and CTC + ENF mixtures in A. fusiformis. However, this model underestimated the experimental results obtained in the OTC + ENF mixture in A. fusiformis. The IA model did not predict the experimental toxicological effects of the three mixtures in either strain. The sum of the toxic units (TU) for the mixtures was calculated. According to these values, the binary mixtures CTC + ENF and OTC + ENF showed an additive effect, and the CTC + OTC mixture showed antagonism in P. subcapitata, whereas the three mixtures showed synergistic effects in A. fusiformis. Although A. fusiformis was isolated from a polluted river, it showed a similar sensitivity with respect to P. subcapitata when it was exposed to binary mixtures of antibiotics. © 2017 Elsevier Ltd
title	Effects of three veterinary antibiotics and their binary mixtures on two green alga species
title_short	Effects of three veterinary antibiotics and their binary mixtures on two green alga species
title_full	Effects of three veterinary antibiotics and their binary mixtures on two green alga species
title_fullStr	Effects of three veterinary antibiotics and their binary mixtures on two green alga species
title_full_unstemmed	Effects of three veterinary antibiotics and their binary mixtures on two green alga species
title_sort	effects of three veterinary antibiotics and their binary mixtures on two green alga species
publishDate	2018
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00456535_v194_n_p821_Carusso http://hdl.handle.net/20.500.12110/paper_00456535_v194_n_p821_Carusso
_version_	1768543027059490816

Effects of three veterinary antibiotics and their binary mixtures on two green alga species

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