Similar regulatory mechanism underlying 3H-noradrenaline release from isolated hypothalamus and perfused tail artery of the rat by Latrodectus antheratus (black widow spider) venom gland extract and by potassium
The release of tritium by Latrodectus antheratus spider venom gland extract, high K+ and tyramine, were studied in two noradrenergically innervated tissues of the rat (the isolated hypothalamus and the perfused tail artery) preloaded with 3H-noradrenaline. An increase in 3H release by venom gland ex...
Guardado en:
| Publicado: |
1981
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00410101_v19_n2_p249_Pardal http://hdl.handle.net/20.500.12110/paper_00410101_v19_n2_p249_Pardal |
| Aporte de: |
| id |
paper:paper_00410101_v19_n2_p249_Pardal |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_00410101_v19_n2_p249_Pardal2023-06-08T15:04:44Z Similar regulatory mechanism underlying 3H-noradrenaline release from isolated hypothalamus and perfused tail artery of the rat by Latrodectus antheratus (black widow spider) venom gland extract and by potassium adrenergic receptor alpha adrenergic receptor methoxamine phenoxybenzamine phentolamine potassium radioisotope tyramine animal experiment artery arthropod central nervous system drug mechanism hypothalamus in vitro study noradrenalin h 3 noradrenalin release peripheral vascular system phenoxamine rat spider tail artery venom gland extract Animal Arteries Arthropod Venoms Black Widow Spider Female Hypothalamus In Vitro Male Methoxamine Muscle, Smooth, Vascular Norepinephrine Phenoxybenzamine Potassium Rats Spider Venoms Support, Non-U.S. Gov't Tyramine The release of tritium by Latrodectus antheratus spider venom gland extract, high K+ and tyramine, were studied in two noradrenergically innervated tissues of the rat (the isolated hypothalamus and the perfused tail artery) preloaded with 3H-noradrenaline. An increase in 3H release by venom gland extract and by K+ was observed in the presence of phenoxybenzamine, an alpha-adrenoceptor blocker. In contrast, the release of 3H by tyramine, an indirect sympathomimetic amine whose action does not depend on the presence of calcium ions, was not modified. Methoxamine, an alpha-adrenoceptor agonist, decreased the 3H release by the venom gland extract and high K+. The results suggest that the venom gland extract releases noradrenaline by a process similar to that evoked by stimulation with high K+, i.e. via a depolarizing mechanism regulated by a negative feedback pathway involving alpha-adrenoceptors. © 1981. 1981 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00410101_v19_n2_p249_Pardal http://hdl.handle.net/20.500.12110/paper_00410101_v19_n2_p249_Pardal |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
adrenergic receptor alpha adrenergic receptor methoxamine phenoxybenzamine phentolamine potassium radioisotope tyramine animal experiment artery arthropod central nervous system drug mechanism hypothalamus in vitro study noradrenalin h 3 noradrenalin release peripheral vascular system phenoxamine rat spider tail artery venom gland extract Animal Arteries Arthropod Venoms Black Widow Spider Female Hypothalamus In Vitro Male Methoxamine Muscle, Smooth, Vascular Norepinephrine Phenoxybenzamine Potassium Rats Spider Venoms Support, Non-U.S. Gov't Tyramine |
| spellingShingle |
adrenergic receptor alpha adrenergic receptor methoxamine phenoxybenzamine phentolamine potassium radioisotope tyramine animal experiment artery arthropod central nervous system drug mechanism hypothalamus in vitro study noradrenalin h 3 noradrenalin release peripheral vascular system phenoxamine rat spider tail artery venom gland extract Animal Arteries Arthropod Venoms Black Widow Spider Female Hypothalamus In Vitro Male Methoxamine Muscle, Smooth, Vascular Norepinephrine Phenoxybenzamine Potassium Rats Spider Venoms Support, Non-U.S. Gov't Tyramine Similar regulatory mechanism underlying 3H-noradrenaline release from isolated hypothalamus and perfused tail artery of the rat by Latrodectus antheratus (black widow spider) venom gland extract and by potassium |
| topic_facet |
adrenergic receptor alpha adrenergic receptor methoxamine phenoxybenzamine phentolamine potassium radioisotope tyramine animal experiment artery arthropod central nervous system drug mechanism hypothalamus in vitro study noradrenalin h 3 noradrenalin release peripheral vascular system phenoxamine rat spider tail artery venom gland extract Animal Arteries Arthropod Venoms Black Widow Spider Female Hypothalamus In Vitro Male Methoxamine Muscle, Smooth, Vascular Norepinephrine Phenoxybenzamine Potassium Rats Spider Venoms Support, Non-U.S. Gov't Tyramine |
| description |
The release of tritium by Latrodectus antheratus spider venom gland extract, high K+ and tyramine, were studied in two noradrenergically innervated tissues of the rat (the isolated hypothalamus and the perfused tail artery) preloaded with 3H-noradrenaline. An increase in 3H release by venom gland extract and by K+ was observed in the presence of phenoxybenzamine, an alpha-adrenoceptor blocker. In contrast, the release of 3H by tyramine, an indirect sympathomimetic amine whose action does not depend on the presence of calcium ions, was not modified. Methoxamine, an alpha-adrenoceptor agonist, decreased the 3H release by the venom gland extract and high K+. The results suggest that the venom gland extract releases noradrenaline by a process similar to that evoked by stimulation with high K+, i.e. via a depolarizing mechanism regulated by a negative feedback pathway involving alpha-adrenoceptors. © 1981. |
| title |
Similar regulatory mechanism underlying 3H-noradrenaline release from isolated hypothalamus and perfused tail artery of the rat by Latrodectus antheratus (black widow spider) venom gland extract and by potassium |
| title_short |
Similar regulatory mechanism underlying 3H-noradrenaline release from isolated hypothalamus and perfused tail artery of the rat by Latrodectus antheratus (black widow spider) venom gland extract and by potassium |
| title_full |
Similar regulatory mechanism underlying 3H-noradrenaline release from isolated hypothalamus and perfused tail artery of the rat by Latrodectus antheratus (black widow spider) venom gland extract and by potassium |
| title_fullStr |
Similar regulatory mechanism underlying 3H-noradrenaline release from isolated hypothalamus and perfused tail artery of the rat by Latrodectus antheratus (black widow spider) venom gland extract and by potassium |
| title_full_unstemmed |
Similar regulatory mechanism underlying 3H-noradrenaline release from isolated hypothalamus and perfused tail artery of the rat by Latrodectus antheratus (black widow spider) venom gland extract and by potassium |
| title_sort |
similar regulatory mechanism underlying 3h-noradrenaline release from isolated hypothalamus and perfused tail artery of the rat by latrodectus antheratus (black widow spider) venom gland extract and by potassium |
| publishDate |
1981 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00410101_v19_n2_p249_Pardal http://hdl.handle.net/20.500.12110/paper_00410101_v19_n2_p249_Pardal |
| _version_ |
1768543600907386880 |