Actions of immunosuppressor drugs on the development of an experimental ovarian tumor

Immunosuppression has been related to the incidence of tumor apparition, including endocrine tumors. The intrasplenic ovarian tumor (luteoma) is a typical benign endocrine tumor that develops under high gonadotropin stimulation and, from the immunological perspective, is located in a critical organ...

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Publicado:	2002
Materias:	Cyclosporin A Dexamethasone Immunosuppression Luteoma cyclosporin A dexamethasone estradiol follitropin immunosuppressive agent luteinizing hormone prolactin animal experiment animal model animal tissue article cancer growth cancer risk chemical carcinogenesis controlled study experimental neoplasm female histopathology immunosuppressive treatment luteoma mouse nonhuman Animals Body Weight Cyclosporine Estradiol Female Follicle Stimulating Hormone Immunocompromised Host Immunosuppressive Agents Luteinizing Hormone Neoplasm Transplantation Organ Size Ovarian Neoplasms Ovariectomy Ovary Prolactin Rats Rats, Sprague-Dawley Spleen Thymus Gland Transplantation, Heterotopic Animalia Castor
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00379727_v227_n8_p658_Sorianello http://hdl.handle.net/20.500.12110/paper_00379727_v227_n8_p658_Sorianello
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	paper:paper_00379727_v227_n8_p658_Sorianello2023-06-08T15:02:25Z Actions of immunosuppressor drugs on the development of an experimental ovarian tumor Cyclosporin A Dexamethasone Immunosuppression Luteoma cyclosporin A dexamethasone estradiol follitropin immunosuppressive agent luteinizing hormone prolactin animal experiment animal model animal tissue article cancer growth cancer risk chemical carcinogenesis controlled study experimental neoplasm female histopathology immunosuppressive treatment luteoma mouse nonhuman Animals Body Weight Cyclosporine Dexamethasone Estradiol Female Follicle Stimulating Hormone Immunocompromised Host Immunosuppressive Agents Luteinizing Hormone Luteoma Neoplasm Transplantation Organ Size Ovarian Neoplasms Ovariectomy Ovary Prolactin Rats Rats, Sprague-Dawley Spleen Thymus Gland Transplantation, Heterotopic Animalia Castor Immunosuppression has been related to the incidence of tumor apparition, including endocrine tumors. The intrasplenic ovarian tumor (luteoma) is a typical benign endocrine tumor that develops under high gonadotropin stimulation and, from the immunological perspective, is located in a critical organ involved in immune response. To establish if immunosuppression could alter the development of this experimental tumor, the effects of cyclosporin A (CsA) and dexamethasone (Dex) were evaluated. After surgery, tumor-bearing and sham animals were kept without treatment for 4 weeks; thereafter, they were distributed into CsA (25 mg/kg), Dex (0.1 mg/kg), or vehicle (75:25 castor oil:ethanol) groups and were injected on alternate days for 50 days. Body weight was evaluated weekly. Animals were sacrificed after a jugular vein blood sample was obtained. Thyml were weighed. Tumors were measured and placed in formaline for histological studies. Serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), and estradiol were measured by radioimmunoassay. Hematological parameters were determined. CsA induced a significant decrease in survival rates both in tumor-bearing and sham animals (P < 0.01). Dex significantly impaired weight increase in both groups of animals. CsA induced a significant weight loss in sham animals, not observed in tumor-bearing animals. Dex induced thymus weight loss in both groups, whereas CsA induced thymus weight loss only in sham animals. Only Dex induced a decrease in lymphocyte number in both groups. CsA induced an increase in monocyte number only in sham animals. Treatments did not alter LH, FSH, or estradiol, whereas PRL was increased by CsA only in sham rats. Neither Dex nor CsA induced any significant variations in tumor volume, nor did they alter tumor histology. In addition, no visible metastases or alterations in other organs were observed. We conclude that, though immunological parameters were altered by the treatments, immunosuppressor drugs did not condition tumor development. In addition, tumors secrete one or more factor/s that counteract CsA effect. 2002 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00379727_v227_n8_p658_Sorianello http://hdl.handle.net/20.500.12110/paper_00379727_v227_n8_p658_Sorianello
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Cyclosporin A Dexamethasone Immunosuppression Luteoma cyclosporin A dexamethasone estradiol follitropin immunosuppressive agent luteinizing hormone prolactin animal experiment animal model animal tissue article cancer growth cancer risk chemical carcinogenesis controlled study experimental neoplasm female histopathology immunosuppressive treatment luteoma mouse nonhuman Animals Body Weight Cyclosporine Dexamethasone Estradiol Female Follicle Stimulating Hormone Immunocompromised Host Immunosuppressive Agents Luteinizing Hormone Luteoma Neoplasm Transplantation Organ Size Ovarian Neoplasms Ovariectomy Ovary Prolactin Rats Rats, Sprague-Dawley Spleen Thymus Gland Transplantation, Heterotopic Animalia Castor
spellingShingle	Cyclosporin A Dexamethasone Immunosuppression Luteoma cyclosporin A dexamethasone estradiol follitropin immunosuppressive agent luteinizing hormone prolactin animal experiment animal model animal tissue article cancer growth cancer risk chemical carcinogenesis controlled study experimental neoplasm female histopathology immunosuppressive treatment luteoma mouse nonhuman Animals Body Weight Cyclosporine Dexamethasone Estradiol Female Follicle Stimulating Hormone Immunocompromised Host Immunosuppressive Agents Luteinizing Hormone Luteoma Neoplasm Transplantation Organ Size Ovarian Neoplasms Ovariectomy Ovary Prolactin Rats Rats, Sprague-Dawley Spleen Thymus Gland Transplantation, Heterotopic Animalia Castor Actions of immunosuppressor drugs on the development of an experimental ovarian tumor
topic_facet	Cyclosporin A Dexamethasone Immunosuppression Luteoma cyclosporin A dexamethasone estradiol follitropin immunosuppressive agent luteinizing hormone prolactin animal experiment animal model animal tissue article cancer growth cancer risk chemical carcinogenesis controlled study experimental neoplasm female histopathology immunosuppressive treatment luteoma mouse nonhuman Animals Body Weight Cyclosporine Dexamethasone Estradiol Female Follicle Stimulating Hormone Immunocompromised Host Immunosuppressive Agents Luteinizing Hormone Luteoma Neoplasm Transplantation Organ Size Ovarian Neoplasms Ovariectomy Ovary Prolactin Rats Rats, Sprague-Dawley Spleen Thymus Gland Transplantation, Heterotopic Animalia Castor
description	Immunosuppression has been related to the incidence of tumor apparition, including endocrine tumors. The intrasplenic ovarian tumor (luteoma) is a typical benign endocrine tumor that develops under high gonadotropin stimulation and, from the immunological perspective, is located in a critical organ involved in immune response. To establish if immunosuppression could alter the development of this experimental tumor, the effects of cyclosporin A (CsA) and dexamethasone (Dex) were evaluated. After surgery, tumor-bearing and sham animals were kept without treatment for 4 weeks; thereafter, they were distributed into CsA (25 mg/kg), Dex (0.1 mg/kg), or vehicle (75:25 castor oil:ethanol) groups and were injected on alternate days for 50 days. Body weight was evaluated weekly. Animals were sacrificed after a jugular vein blood sample was obtained. Thyml were weighed. Tumors were measured and placed in formaline for histological studies. Serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), and estradiol were measured by radioimmunoassay. Hematological parameters were determined. CsA induced a significant decrease in survival rates both in tumor-bearing and sham animals (P < 0.01). Dex significantly impaired weight increase in both groups of animals. CsA induced a significant weight loss in sham animals, not observed in tumor-bearing animals. Dex induced thymus weight loss in both groups, whereas CsA induced thymus weight loss only in sham animals. Only Dex induced a decrease in lymphocyte number in both groups. CsA induced an increase in monocyte number only in sham animals. Treatments did not alter LH, FSH, or estradiol, whereas PRL was increased by CsA only in sham rats. Neither Dex nor CsA induced any significant variations in tumor volume, nor did they alter tumor histology. In addition, no visible metastases or alterations in other organs were observed. We conclude that, though immunological parameters were altered by the treatments, immunosuppressor drugs did not condition tumor development. In addition, tumors secrete one or more factor/s that counteract CsA effect.
title	Actions of immunosuppressor drugs on the development of an experimental ovarian tumor
title_short	Actions of immunosuppressor drugs on the development of an experimental ovarian tumor
title_full	Actions of immunosuppressor drugs on the development of an experimental ovarian tumor
title_fullStr	Actions of immunosuppressor drugs on the development of an experimental ovarian tumor
title_full_unstemmed	Actions of immunosuppressor drugs on the development of an experimental ovarian tumor
title_sort	actions of immunosuppressor drugs on the development of an experimental ovarian tumor
publishDate	2002
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00379727_v227_n8_p658_Sorianello http://hdl.handle.net/20.500.12110/paper_00379727_v227_n8_p658_Sorianello
_version_	1768542589048324096

Actions of immunosuppressor drugs on the development of an experimental ovarian tumor

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