Bioactive constituents of Conyza albida

The bioactivity-guided fractionation of an active chloroform extract of Conyza albida led to the isolation of three alkenynes, deca-4,6-diyn-2-(Z)-enoic methyl ester (1), deca-4,6-diyn-2-(Z)-enoic ethyl ester (2) and deca-2,4-diene-4-hydroxy-6-yn-l,4-olide (3), and the terpenoid spathulenol (4), as...

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Publicado:	2000
Materias:	Alkenynes Compositae Conyza albida Cytotoxic activity DNA interaction DNA strand scission Topoisomerase 1 chloroform deca 2,4 diene 4 hydroxy 6 yn 1,4 olide deca 4,6 diyn 2 enoic ethyl ester deca 4,6 diyn 2 enoic methyl ester DNA DNA topoisomerase methyl green plant extract spathulenol unclassified drug animal experiment article controlled study cytotoxicity drug activity fractionation human human cell medicinal plant nonhuman plant leaf shrimp Asteraceae Humans Molecular Structure Plant Extracts Spectrum Analysis
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00320943_v66_n8_p720_DelPacciaroni http://hdl.handle.net/20.500.12110/paper_00320943_v66_n8_p720_DelPacciaroni
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00320943_v66_n8_p720_DelPacciaroni
record_format	dspace
spelling	paper:paper_00320943_v66_n8_p720_DelPacciaroni2023-06-08T15:00:06Z Bioactive constituents of Conyza albida Alkenynes Compositae Conyza albida Cytotoxic activity DNA interaction DNA strand scission Topoisomerase 1 chloroform deca 2,4 diene 4 hydroxy 6 yn 1,4 olide deca 4,6 diyn 2 enoic ethyl ester deca 4,6 diyn 2 enoic methyl ester DNA DNA topoisomerase methyl green plant extract spathulenol unclassified drug animal experiment article controlled study cytotoxicity drug activity fractionation human human cell medicinal plant nonhuman plant leaf shrimp Asteraceae Humans Molecular Structure Plant Extracts Spectrum Analysis The bioactivity-guided fractionation of an active chloroform extract of Conyza albida led to the isolation of three alkenynes, deca-4,6-diyn-2-(Z)-enoic methyl ester (1), deca-4,6-diyn-2-(Z)-enoic ethyl ester (2) and deca-2,4-diene-4-hydroxy-6-yn-l,4-olide (3), and the terpenoid spathulenol (4), as the active toxic metabolites in the Artemia sp. lethality test. When tested in the KB cell cytotoxicity assay, compounds 1-4 demonstrated 1C 50 values of 52.2, 38.4, 117.9, and 83.8 μM, respectively. All compounds studied were inactive in the DNA methyl green and DNA strand scission assays, while compounds 3 and 4 showed moderate activity as inhibitors of human topoisomerase I. Compound 2 is reported here for the first time. 2000 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00320943_v66_n8_p720_DelPacciaroni http://hdl.handle.net/20.500.12110/paper_00320943_v66_n8_p720_DelPacciaroni
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Alkenynes Compositae Conyza albida Cytotoxic activity DNA interaction DNA strand scission Topoisomerase 1 chloroform deca 2,4 diene 4 hydroxy 6 yn 1,4 olide deca 4,6 diyn 2 enoic ethyl ester deca 4,6 diyn 2 enoic methyl ester DNA DNA topoisomerase methyl green plant extract spathulenol unclassified drug animal experiment article controlled study cytotoxicity drug activity fractionation human human cell medicinal plant nonhuman plant leaf shrimp Asteraceae Humans Molecular Structure Plant Extracts Spectrum Analysis
spellingShingle	Alkenynes Compositae Conyza albida Cytotoxic activity DNA interaction DNA strand scission Topoisomerase 1 chloroform deca 2,4 diene 4 hydroxy 6 yn 1,4 olide deca 4,6 diyn 2 enoic ethyl ester deca 4,6 diyn 2 enoic methyl ester DNA DNA topoisomerase methyl green plant extract spathulenol unclassified drug animal experiment article controlled study cytotoxicity drug activity fractionation human human cell medicinal plant nonhuman plant leaf shrimp Asteraceae Humans Molecular Structure Plant Extracts Spectrum Analysis Bioactive constituents of Conyza albida
topic_facet	Alkenynes Compositae Conyza albida Cytotoxic activity DNA interaction DNA strand scission Topoisomerase 1 chloroform deca 2,4 diene 4 hydroxy 6 yn 1,4 olide deca 4,6 diyn 2 enoic ethyl ester deca 4,6 diyn 2 enoic methyl ester DNA DNA topoisomerase methyl green plant extract spathulenol unclassified drug animal experiment article controlled study cytotoxicity drug activity fractionation human human cell medicinal plant nonhuman plant leaf shrimp Asteraceae Humans Molecular Structure Plant Extracts Spectrum Analysis
description	The bioactivity-guided fractionation of an active chloroform extract of Conyza albida led to the isolation of three alkenynes, deca-4,6-diyn-2-(Z)-enoic methyl ester (1), deca-4,6-diyn-2-(Z)-enoic ethyl ester (2) and deca-2,4-diene-4-hydroxy-6-yn-l,4-olide (3), and the terpenoid spathulenol (4), as the active toxic metabolites in the Artemia sp. lethality test. When tested in the KB cell cytotoxicity assay, compounds 1-4 demonstrated 1C 50 values of 52.2, 38.4, 117.9, and 83.8 μM, respectively. All compounds studied were inactive in the DNA methyl green and DNA strand scission assays, while compounds 3 and 4 showed moderate activity as inhibitors of human topoisomerase I. Compound 2 is reported here for the first time.
title	Bioactive constituents of Conyza albida
title_short	Bioactive constituents of Conyza albida
title_full	Bioactive constituents of Conyza albida
title_fullStr	Bioactive constituents of Conyza albida
title_full_unstemmed	Bioactive constituents of Conyza albida
title_sort	bioactive constituents of conyza albida
publishDate	2000
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00320943_v66_n8_p720_DelPacciaroni http://hdl.handle.net/20.500.12110/paper_00320943_v66_n8_p720_DelPacciaroni
_version_	1768545821635117056

Bioactive constituents of Conyza albida

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