Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors
Malnutrition is a worldwide problem affecting millions of unborn and young children during the most vulnerable stages of their development. In humans, poor maternal nutrition is a major cause of intrauterine growth restriction which is associated with an increased risk of perinatal mortality and lon...
Guardado en:
| Autores principales: | , |
|---|---|
| Publicado: |
2014
|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319384_v129_n_p237_Belluscio http://hdl.handle.net/20.500.12110/paper_00319384_v129_n_p237_Belluscio |
| Aporte de: |
| id |
paper:paper_00319384_v129_n_p237_Belluscio |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_00319384_v129_n_p237_Belluscio2023-06-08T14:59:02Z Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors Ceruti, Julieta María Cánepa, Eduardo Tomás Anxiety-related behavior Depressive-related behavior Maternal care Neurodevelopment Perinatal protein malnutrition Social behavior animal experiment anxiety disorder article controlled study depression exploratory behavior female growth lactation male malnutrition maternal care motivation mouse nervous system development nonhuman play pregnancy priority journal protein restriction reflex risk assessment social interaction animal animal behavior anxiety complication decision making depression etiology inbred mouse strain maternal behavior maternal nutrition physiology prenatal exposure protein calorie malnutrition risk sex difference social behavior Animals Anxiety Behavior, Animal Decision Making Depression Exploratory Behavior Female Growth Lactation Male Maternal Behavior Maternal Nutritional Physiological Phenomena Mice, Inbred Strains Motivation Pregnancy Prenatal Exposure Delayed Effects Protein-Energy Malnutrition Reflex Risk Sex Factors Social Behavior Malnutrition is a worldwide problem affecting millions of unborn and young children during the most vulnerable stages of their development. In humans, poor maternal nutrition is a major cause of intrauterine growth restriction which is associated with an increased risk of perinatal mortality and long-term morbidity. In addition, intrauterine growth restriction correlates with neurodevelopmental delays and alterations of brain structure and neurochemistry. While there is no doubt that maternal malnutrition is a principal cause of perturbed development of the fetal brain and that all nutrients have certain influence on brain maturation, proteins appear to be the most critical for the development of neurological functions. In the present study we assessed male and female mouse offspring, born to dams protein restricted during pregnancy and lactation, in physical growth and neurobehavioral development and also in social interaction, motivation, anxiety and depressive behaviors. Moreover, we evaluate the impact of the low protein diet on dams in relation to their maternal care and anxiety-related behavior given that these clearly affect pups development. We observed that maternal protein restriction during pregnancy and lactation delayed the physical growth and neurodevelopment of the offspring in a sex-independent manner. In addition, maternal undernutrition negatively affected offspring's juvenile social play, motivation, exploratory activity and risk assessment behaviors. These findings show that protein restriction during critical periods of development detrimentally program progeny behavior. © 2014 Elsevier Inc. Fil:Ceruti, J.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cánepa, E.T. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319384_v129_n_p237_Belluscio http://hdl.handle.net/20.500.12110/paper_00319384_v129_n_p237_Belluscio |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Anxiety-related behavior Depressive-related behavior Maternal care Neurodevelopment Perinatal protein malnutrition Social behavior animal experiment anxiety disorder article controlled study depression exploratory behavior female growth lactation male malnutrition maternal care motivation mouse nervous system development nonhuman play pregnancy priority journal protein restriction reflex risk assessment social interaction animal animal behavior anxiety complication decision making depression etiology inbred mouse strain maternal behavior maternal nutrition physiology prenatal exposure protein calorie malnutrition risk sex difference social behavior Animals Anxiety Behavior, Animal Decision Making Depression Exploratory Behavior Female Growth Lactation Male Maternal Behavior Maternal Nutritional Physiological Phenomena Mice, Inbred Strains Motivation Pregnancy Prenatal Exposure Delayed Effects Protein-Energy Malnutrition Reflex Risk Sex Factors Social Behavior |
| spellingShingle |
Anxiety-related behavior Depressive-related behavior Maternal care Neurodevelopment Perinatal protein malnutrition Social behavior animal experiment anxiety disorder article controlled study depression exploratory behavior female growth lactation male malnutrition maternal care motivation mouse nervous system development nonhuman play pregnancy priority journal protein restriction reflex risk assessment social interaction animal animal behavior anxiety complication decision making depression etiology inbred mouse strain maternal behavior maternal nutrition physiology prenatal exposure protein calorie malnutrition risk sex difference social behavior Animals Anxiety Behavior, Animal Decision Making Depression Exploratory Behavior Female Growth Lactation Male Maternal Behavior Maternal Nutritional Physiological Phenomena Mice, Inbred Strains Motivation Pregnancy Prenatal Exposure Delayed Effects Protein-Energy Malnutrition Reflex Risk Sex Factors Social Behavior Ceruti, Julieta María Cánepa, Eduardo Tomás Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors |
| topic_facet |
Anxiety-related behavior Depressive-related behavior Maternal care Neurodevelopment Perinatal protein malnutrition Social behavior animal experiment anxiety disorder article controlled study depression exploratory behavior female growth lactation male malnutrition maternal care motivation mouse nervous system development nonhuman play pregnancy priority journal protein restriction reflex risk assessment social interaction animal animal behavior anxiety complication decision making depression etiology inbred mouse strain maternal behavior maternal nutrition physiology prenatal exposure protein calorie malnutrition risk sex difference social behavior Animals Anxiety Behavior, Animal Decision Making Depression Exploratory Behavior Female Growth Lactation Male Maternal Behavior Maternal Nutritional Physiological Phenomena Mice, Inbred Strains Motivation Pregnancy Prenatal Exposure Delayed Effects Protein-Energy Malnutrition Reflex Risk Sex Factors Social Behavior |
| description |
Malnutrition is a worldwide problem affecting millions of unborn and young children during the most vulnerable stages of their development. In humans, poor maternal nutrition is a major cause of intrauterine growth restriction which is associated with an increased risk of perinatal mortality and long-term morbidity. In addition, intrauterine growth restriction correlates with neurodevelopmental delays and alterations of brain structure and neurochemistry. While there is no doubt that maternal malnutrition is a principal cause of perturbed development of the fetal brain and that all nutrients have certain influence on brain maturation, proteins appear to be the most critical for the development of neurological functions. In the present study we assessed male and female mouse offspring, born to dams protein restricted during pregnancy and lactation, in physical growth and neurobehavioral development and also in social interaction, motivation, anxiety and depressive behaviors. Moreover, we evaluate the impact of the low protein diet on dams in relation to their maternal care and anxiety-related behavior given that these clearly affect pups development. We observed that maternal protein restriction during pregnancy and lactation delayed the physical growth and neurodevelopment of the offspring in a sex-independent manner. In addition, maternal undernutrition negatively affected offspring's juvenile social play, motivation, exploratory activity and risk assessment behaviors. These findings show that protein restriction during critical periods of development detrimentally program progeny behavior. © 2014 Elsevier Inc. |
| author |
Ceruti, Julieta María Cánepa, Eduardo Tomás |
| author_facet |
Ceruti, Julieta María Cánepa, Eduardo Tomás |
| author_sort |
Ceruti, Julieta María |
| title |
Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors |
| title_short |
Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors |
| title_full |
Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors |
| title_fullStr |
Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors |
| title_full_unstemmed |
Early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors |
| title_sort |
early protein malnutrition negatively impacts physical growth and neurological reflexes and evokes anxiety and depressive-like behaviors |
| publishDate |
2014 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319384_v129_n_p237_Belluscio http://hdl.handle.net/20.500.12110/paper_00319384_v129_n_p237_Belluscio |
| work_keys_str_mv |
AT cerutijulietamaria earlyproteinmalnutritionnegativelyimpactsphysicalgrowthandneurologicalreflexesandevokesanxietyanddepressivelikebehaviors AT canepaeduardotomas earlyproteinmalnutritionnegativelyimpactsphysicalgrowthandneurologicalreflexesandevokesanxietyanddepressivelikebehaviors |
| _version_ |
1768542588471607296 |