Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata

Conspicuous and sustained heart arrests, revealed as an increase in the magnitude of cardiac interbeat intervals, are elicited in the crab Neohelice granulata upon the presentation of a visual danger stimulus (VDS). Aiming to study the regulation of cardio-inhibitory responses (CIR) in vivo, we inve...

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Autores principales: Carbó Tano, Martín, Hermitte, Gabriela
Publicado: 2013
Materias:
Autonomic system
Cardiac response
GABA
Heart arrest
Invertebrate
4 aminobutyric acid
bicuculline
picrotoxin
animal experiment
animal model
article
bradycardia
cardioinhibitory response
controlled study
crab
heart arrest
heart beat
heart contraction
heart function
heart rate
in vivo study
male
nonhuman
priority journal
visual stimulation
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319384_v110-111_n_p198_Yang
http://hdl.handle.net/20.500.12110/paper_00319384_v110-111_n_p198_Yang
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_00319384_v110-111_n_p198_Yang
record_format dspace
spelling paper:paper_00319384_v110-111_n_p198_Yang2023-06-08T14:59:02Z Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata Carbó Tano, Martín Hermitte, Gabriela Autonomic system Cardiac response GABA Heart arrest Invertebrate 4 aminobutyric acid bicuculline picrotoxin animal experiment animal model article bradycardia cardioinhibitory response controlled study crab heart arrest heart beat heart contraction heart function heart rate in vivo study male nonhuman priority journal visual stimulation Conspicuous and sustained heart arrests, revealed as an increase in the magnitude of cardiac interbeat intervals, are elicited in the crab Neohelice granulata upon the presentation of a visual danger stimulus (VDS). Aiming to study the regulation of cardio-inhibitory responses (CIR) in vivo, we investigated whether GABA mediates the extrinsic regulation of the cardiac activity. We examined the possibility of abolishing CIR by injecting the GABAergic antagonists picrotoxin and bicuculline, right before sensory stimulation. Picrotoxin partially abolished the reversible cardiac arrests induced by VDS, whereas bicuculline showed no effects. These results suggest that the rapid responses of the cardiac system of the crab Neohelice to environmental disturbances, reminiscent of an autonomic-like regulation associated with fear, flight or fight, may be extrinsically regulated by the GABAergic system. © 2012 Elsevier Inc. Fil:Carbó Tano, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Hermitte, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319384_v110-111_n_p198_Yang http://hdl.handle.net/20.500.12110/paper_00319384_v110-111_n_p198_Yang
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Autonomic system
Cardiac response
GABA
Heart arrest
Invertebrate
4 aminobutyric acid
bicuculline
picrotoxin
animal experiment
animal model
article
bradycardia
cardioinhibitory response
controlled study
crab
heart arrest
heart beat
heart contraction
heart function
heart rate
in vivo study
male
nonhuman
priority journal
visual stimulation
spellingShingle Autonomic system
Cardiac response
GABA
Heart arrest
Invertebrate
4 aminobutyric acid
bicuculline
picrotoxin
animal experiment
animal model
article
bradycardia
cardioinhibitory response
controlled study
crab
heart arrest
heart beat
heart contraction
heart function
heart rate
in vivo study
male
nonhuman
priority journal
visual stimulation
Carbó Tano, Martín
Hermitte, Gabriela
Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata
topic_facet Autonomic system
Cardiac response
GABA
Heart arrest
Invertebrate
4 aminobutyric acid
bicuculline
picrotoxin
animal experiment
animal model
article
bradycardia
cardioinhibitory response
controlled study
crab
heart arrest
heart beat
heart contraction
heart function
heart rate
in vivo study
male
nonhuman
priority journal
visual stimulation
description Conspicuous and sustained heart arrests, revealed as an increase in the magnitude of cardiac interbeat intervals, are elicited in the crab Neohelice granulata upon the presentation of a visual danger stimulus (VDS). Aiming to study the regulation of cardio-inhibitory responses (CIR) in vivo, we investigated whether GABA mediates the extrinsic regulation of the cardiac activity. We examined the possibility of abolishing CIR by injecting the GABAergic antagonists picrotoxin and bicuculline, right before sensory stimulation. Picrotoxin partially abolished the reversible cardiac arrests induced by VDS, whereas bicuculline showed no effects. These results suggest that the rapid responses of the cardiac system of the crab Neohelice to environmental disturbances, reminiscent of an autonomic-like regulation associated with fear, flight or fight, may be extrinsically regulated by the GABAergic system. © 2012 Elsevier Inc.
author Carbó Tano, Martín
Hermitte, Gabriela
author_facet Carbó Tano, Martín
Hermitte, Gabriela
author_sort Carbó Tano, Martín
title Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata
title_short Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata
title_full Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata
title_fullStr Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata
title_full_unstemmed Picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab Neohelice granulata
title_sort picrotoxin but not bicuculline partially abolishes the cardio-inhibitory responses induced by visual stimulation in the crab neohelice granulata
publishDate 2013
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319384_v110-111_n_p198_Yang
http://hdl.handle.net/20.500.12110/paper_00319384_v110-111_n_p198_Yang
work_keys_str_mv AT carbotanomartin picrotoxinbutnotbicucullinepartiallyabolishesthecardioinhibitoryresponsesinducedbyvisualstimulationinthecrabneohelicegranulata
AT hermittegabriela picrotoxinbutnotbicucullinepartiallyabolishesthecardioinhibitoryresponsesinducedbyvisualstimulationinthecrabneohelicegranulata
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