Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms
Dose-response curves of the positive inotropic effect of PGF2α on isolated rat atria, were examined. It was found a distinct efficacy stimulating the contractile tension of isolated rat atria. The compound elicited a positive inotropism which was augmented in the presence of (-)-propranolol, subthre...
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1981
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v13_n6_p559_Canga http://hdl.handle.net/20.500.12110/paper_00316989_v13_n6_p559_Canga |
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paper:paper_00316989_v13_n6_p559_Canga2023-06-08T14:57:07Z Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms methoxamine noradrenalin phentolamine propranolol prostaglandin F prostaglandin F2 alpha adrenergic receptor methoxamine noradrenalin oxidopamine phentolamine propranolol prostaglandin f2 alpha tyramine adrenergic system animal article chemical sympathectomy drug effect heart atrium heart contraction in vitro study innervation male rat rat strain stimulation adrenergic system animal experiment autonomic nervous system drug response heart heart atrium heart muscle contractility inotropism Animal Dinoprost Heart Atrium In Vitro Male Methoxamine Myocardial Contraction Norepinephrine Phentolamine Propranolol Prostaglandins F Rats Rats, Inbred Strains Stimulation, Chemical Support, Non-U.S. Gov't Sympathectomy, Chemical Sympathetic Nervous System Dose-response curves of the positive inotropic effect of PGF2α on isolated rat atria, were examined. It was found a distinct efficacy stimulating the contractile tension of isolated rat atria. The compound elicited a positive inotropism which was augmented in the presence of (-)-propranolol, subthreshold doses of methoxamine, as well as after a treatment with 6-OHDA. On the contrary subthreshold concentrations of norepinephrine or the presence of phentolamine decreased the augmenting inotropic effect of PGF2α. The results suggest that the action of PGF2α is apparently direct and not mediated by the release of the tissue catecholamines. However, adrenergic mechanism appear to be somehow involved in the inotropic influence of PGF2α on the rat atria. © 1981 The Italian Pharmacological Society. 1981 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v13_n6_p559_Canga http://hdl.handle.net/20.500.12110/paper_00316989_v13_n6_p559_Canga |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
methoxamine noradrenalin phentolamine propranolol prostaglandin F prostaglandin F2 alpha adrenergic receptor methoxamine noradrenalin oxidopamine phentolamine propranolol prostaglandin f2 alpha tyramine adrenergic system animal article chemical sympathectomy drug effect heart atrium heart contraction in vitro study innervation male rat rat strain stimulation adrenergic system animal experiment autonomic nervous system drug response heart heart atrium heart muscle contractility inotropism Animal Dinoprost Heart Atrium In Vitro Male Methoxamine Myocardial Contraction Norepinephrine Phentolamine Propranolol Prostaglandins F Rats Rats, Inbred Strains Stimulation, Chemical Support, Non-U.S. Gov't Sympathectomy, Chemical Sympathetic Nervous System |
| spellingShingle |
methoxamine noradrenalin phentolamine propranolol prostaglandin F prostaglandin F2 alpha adrenergic receptor methoxamine noradrenalin oxidopamine phentolamine propranolol prostaglandin f2 alpha tyramine adrenergic system animal article chemical sympathectomy drug effect heart atrium heart contraction in vitro study innervation male rat rat strain stimulation adrenergic system animal experiment autonomic nervous system drug response heart heart atrium heart muscle contractility inotropism Animal Dinoprost Heart Atrium In Vitro Male Methoxamine Myocardial Contraction Norepinephrine Phentolamine Propranolol Prostaglandins F Rats Rats, Inbred Strains Stimulation, Chemical Support, Non-U.S. Gov't Sympathectomy, Chemical Sympathetic Nervous System Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms |
| topic_facet |
methoxamine noradrenalin phentolamine propranolol prostaglandin F prostaglandin F2 alpha adrenergic receptor methoxamine noradrenalin oxidopamine phentolamine propranolol prostaglandin f2 alpha tyramine adrenergic system animal article chemical sympathectomy drug effect heart atrium heart contraction in vitro study innervation male rat rat strain stimulation adrenergic system animal experiment autonomic nervous system drug response heart heart atrium heart muscle contractility inotropism Animal Dinoprost Heart Atrium In Vitro Male Methoxamine Myocardial Contraction Norepinephrine Phentolamine Propranolol Prostaglandins F Rats Rats, Inbred Strains Stimulation, Chemical Support, Non-U.S. Gov't Sympathectomy, Chemical Sympathetic Nervous System |
| description |
Dose-response curves of the positive inotropic effect of PGF2α on isolated rat atria, were examined. It was found a distinct efficacy stimulating the contractile tension of isolated rat atria. The compound elicited a positive inotropism which was augmented in the presence of (-)-propranolol, subthreshold doses of methoxamine, as well as after a treatment with 6-OHDA. On the contrary subthreshold concentrations of norepinephrine or the presence of phentolamine decreased the augmenting inotropic effect of PGF2α. The results suggest that the action of PGF2α is apparently direct and not mediated by the release of the tissue catecholamines. However, adrenergic mechanism appear to be somehow involved in the inotropic influence of PGF2α on the rat atria. © 1981 The Italian Pharmacological Society. |
| title |
Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms |
| title_short |
Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms |
| title_full |
Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms |
| title_fullStr |
Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms |
| title_full_unstemmed |
Inotropic effect of PGF2α on isolated rat atria. Influence of adrenergic mechanisms |
| title_sort |
inotropic effect of pgf2α on isolated rat atria. influence of adrenergic mechanisms |
| publishDate |
1981 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v13_n6_p559_Canga http://hdl.handle.net/20.500.12110/paper_00316989_v13_n6_p559_Canga |
| _version_ |
1768542305644445696 |