Pharmacologic influences on human ovarian contractions
Spontaneous motility in whole ovarian follicles, as well as in strips from the stroma and capsule of ovaries, isolated from premenopausal and menopausal women, was explored. The pharmacologic contractile reactivity of these ovarian structures to different smooth muscle stimulating agents, ie, prosta...
Guardado en:
| Publicado: |
1976
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00297844_v47_n2_p218_Gimeno http://hdl.handle.net/20.500.12110/paper_00297844_v47_n2_p218_Gimeno |
| Aporte de: |
| id |
paper:paper_00297844_v47_n2_p218_Gimeno |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_00297844_v47_n2_p218_Gimeno2023-06-08T14:55:34Z Pharmacologic influences on human ovarian contractions acetylcholine noradrenalin phentolamine phenylephrine prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha serotonin drug interaction normal human ovary ovary contractility theoretical study Acetylcholine Adult Female Humans Menopause Middle Aged Muscle Contraction Muscle, Smooth Norepinephrine Ovary Ovulation Phentolamine Phenylephrine Prostaglandins E Prostaglandins F Serotonin Spontaneous motility in whole ovarian follicles, as well as in strips from the stroma and capsule of ovaries, isolated from premenopausal and menopausal women, was explored. The pharmacologic contractile reactivity of these ovarian structures to different smooth muscle stimulating agents, ie, prostaglandins E 1, E 2, F 2α; norepinephrine; 5 hydroxytriptamine; acetylcholine; phenylephrine; and phentolamine, was also studied. Strips from the capsule and stroma of isolated ovaries showed spontaneous motility in both menopausal and non menopausal preparations. The addition of phenylephrine, norepinephrine, acetylcholine, 5 HT, or PGF 2α induced a sustained tonic contractile tension, whereas PGE 1 elicited the opposite influence. Stromal strips from nonmenopausal women showed more reaction to norepinephrine than those from menopausal ones. Ovarian follicles did not exhibit spontaneous motility but responded to added norepinephrine. This influence was blocked by phentolamine, indicating the eventual participation of alphaadrenergic receptors. Acetylcholine, PGF 2α and, to a smaller extent, PGE 2 also increase follicular resting tension. On the contrary, PGE 1 was clearly inhibitory both upon the spontaneous basal tone and the PGF 2α induced sustained contractions. 1976 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00297844_v47_n2_p218_Gimeno http://hdl.handle.net/20.500.12110/paper_00297844_v47_n2_p218_Gimeno |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
acetylcholine noradrenalin phentolamine phenylephrine prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha serotonin drug interaction normal human ovary ovary contractility theoretical study Acetylcholine Adult Female Humans Menopause Middle Aged Muscle Contraction Muscle, Smooth Norepinephrine Ovary Ovulation Phentolamine Phenylephrine Prostaglandins E Prostaglandins F Serotonin |
| spellingShingle |
acetylcholine noradrenalin phentolamine phenylephrine prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha serotonin drug interaction normal human ovary ovary contractility theoretical study Acetylcholine Adult Female Humans Menopause Middle Aged Muscle Contraction Muscle, Smooth Norepinephrine Ovary Ovulation Phentolamine Phenylephrine Prostaglandins E Prostaglandins F Serotonin Pharmacologic influences on human ovarian contractions |
| topic_facet |
acetylcholine noradrenalin phentolamine phenylephrine prostaglandin prostaglandin e1 prostaglandin e2 prostaglandin f2 alpha serotonin drug interaction normal human ovary ovary contractility theoretical study Acetylcholine Adult Female Humans Menopause Middle Aged Muscle Contraction Muscle, Smooth Norepinephrine Ovary Ovulation Phentolamine Phenylephrine Prostaglandins E Prostaglandins F Serotonin |
| description |
Spontaneous motility in whole ovarian follicles, as well as in strips from the stroma and capsule of ovaries, isolated from premenopausal and menopausal women, was explored. The pharmacologic contractile reactivity of these ovarian structures to different smooth muscle stimulating agents, ie, prostaglandins E 1, E 2, F 2α; norepinephrine; 5 hydroxytriptamine; acetylcholine; phenylephrine; and phentolamine, was also studied. Strips from the capsule and stroma of isolated ovaries showed spontaneous motility in both menopausal and non menopausal preparations. The addition of phenylephrine, norepinephrine, acetylcholine, 5 HT, or PGF 2α induced a sustained tonic contractile tension, whereas PGE 1 elicited the opposite influence. Stromal strips from nonmenopausal women showed more reaction to norepinephrine than those from menopausal ones. Ovarian follicles did not exhibit spontaneous motility but responded to added norepinephrine. This influence was blocked by phentolamine, indicating the eventual participation of alphaadrenergic receptors. Acetylcholine, PGF 2α and, to a smaller extent, PGE 2 also increase follicular resting tension. On the contrary, PGE 1 was clearly inhibitory both upon the spontaneous basal tone and the PGF 2α induced sustained contractions. |
| title |
Pharmacologic influences on human ovarian contractions |
| title_short |
Pharmacologic influences on human ovarian contractions |
| title_full |
Pharmacologic influences on human ovarian contractions |
| title_fullStr |
Pharmacologic influences on human ovarian contractions |
| title_full_unstemmed |
Pharmacologic influences on human ovarian contractions |
| title_sort |
pharmacologic influences on human ovarian contractions |
| publishDate |
1976 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00297844_v47_n2_p218_Gimeno http://hdl.handle.net/20.500.12110/paper_00297844_v47_n2_p218_Gimeno |
| _version_ |
1768542775615160320 |