State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder
Anatomical and functional brain studies have converged to the hypothesis that autism spectrum disorders (ASD) are associated with atypical connectivity. Using a modified resting-state paradigm to drive subjects' attention, we provide evidence of a very marked interaction between ASD brain funct...
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2012
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paper:paper_00283932_v50_n14_p3653_Barttfeld2023-06-08T14:55:11Z State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder Leiguarda, Ramón Héctor Sigman, Mariano ADOS score Autism spectrum disorders Brain states Functional connectivity adult angular gyrus anterior cingulate anterior insula article attention autism basal ganglion brain region clinical article cognition controlled study disease association disease severity DSM-IV female functional magnetic resonance imaging human inferior parietal lobule inferior temporal cortex male precuneus prefrontal cortex state dependent learning Adolescent Attention Deficit Disorder with Hyperactivity Brain Brain Mapping Child Child Development Disorders, Pervasive Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Neural Pathways Oxygen Rest Young Adult Anatomical and functional brain studies have converged to the hypothesis that autism spectrum disorders (ASD) are associated with atypical connectivity. Using a modified resting-state paradigm to drive subjects' attention, we provide evidence of a very marked interaction between ASD brain functional connectivity and cognitive state. We show that functional connectivity changes in opposite ways in ASD and typicals as attention shifts from external world towards one's body generated information. Furthermore, ASD subject alter more markedly than typicals their connectivity across cognitive states. Using differences in brain connectivity across conditions, we ranked brain regions according to their classification power. Anterior insula and dorsal-anterior cingulate cortex were the regions that better characterize ASD differences with typical subjects across conditions, and this effect was modulated by ASD severity. These results pave the path for diagnosis of mental pathologies based on functional brain networks obtained from a library of mental states. © 2012 Elsevier Ltd. Fil:Leiguarda, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sigman, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283932_v50_n14_p3653_Barttfeld http://hdl.handle.net/20.500.12110/paper_00283932_v50_n14_p3653_Barttfeld |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
ADOS score Autism spectrum disorders Brain states Functional connectivity adult angular gyrus anterior cingulate anterior insula article attention autism basal ganglion brain region clinical article cognition controlled study disease association disease severity DSM-IV female functional magnetic resonance imaging human inferior parietal lobule inferior temporal cortex male precuneus prefrontal cortex state dependent learning Adolescent Attention Deficit Disorder with Hyperactivity Brain Brain Mapping Child Child Development Disorders, Pervasive Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Neural Pathways Oxygen Rest Young Adult |
| spellingShingle |
ADOS score Autism spectrum disorders Brain states Functional connectivity adult angular gyrus anterior cingulate anterior insula article attention autism basal ganglion brain region clinical article cognition controlled study disease association disease severity DSM-IV female functional magnetic resonance imaging human inferior parietal lobule inferior temporal cortex male precuneus prefrontal cortex state dependent learning Adolescent Attention Deficit Disorder with Hyperactivity Brain Brain Mapping Child Child Development Disorders, Pervasive Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Neural Pathways Oxygen Rest Young Adult Leiguarda, Ramón Héctor Sigman, Mariano State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder |
| topic_facet |
ADOS score Autism spectrum disorders Brain states Functional connectivity adult angular gyrus anterior cingulate anterior insula article attention autism basal ganglion brain region clinical article cognition controlled study disease association disease severity DSM-IV female functional magnetic resonance imaging human inferior parietal lobule inferior temporal cortex male precuneus prefrontal cortex state dependent learning Adolescent Attention Deficit Disorder with Hyperactivity Brain Brain Mapping Child Child Development Disorders, Pervasive Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Neural Pathways Oxygen Rest Young Adult |
| description |
Anatomical and functional brain studies have converged to the hypothesis that autism spectrum disorders (ASD) are associated with atypical connectivity. Using a modified resting-state paradigm to drive subjects' attention, we provide evidence of a very marked interaction between ASD brain functional connectivity and cognitive state. We show that functional connectivity changes in opposite ways in ASD and typicals as attention shifts from external world towards one's body generated information. Furthermore, ASD subject alter more markedly than typicals their connectivity across cognitive states. Using differences in brain connectivity across conditions, we ranked brain regions according to their classification power. Anterior insula and dorsal-anterior cingulate cortex were the regions that better characterize ASD differences with typical subjects across conditions, and this effect was modulated by ASD severity. These results pave the path for diagnosis of mental pathologies based on functional brain networks obtained from a library of mental states. © 2012 Elsevier Ltd. |
| author |
Leiguarda, Ramón Héctor Sigman, Mariano |
| author_facet |
Leiguarda, Ramón Héctor Sigman, Mariano |
| author_sort |
Leiguarda, Ramón Héctor |
| title |
State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder |
| title_short |
State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder |
| title_full |
State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder |
| title_fullStr |
State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder |
| title_full_unstemmed |
State-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder |
| title_sort |
state-dependent changes of connectivity patterns and functional brain network topology in autism spectrum disorder |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283932_v50_n14_p3653_Barttfeld http://hdl.handle.net/20.500.12110/paper_00283932_v50_n14_p3653_Barttfeld |
| work_keys_str_mv |
AT leiguardaramonhector statedependentchangesofconnectivitypatternsandfunctionalbrainnetworktopologyinautismspectrumdisorder AT sigmanmariano statedependentchangesofconnectivitypatternsandfunctionalbrainnetworktopologyinautismspectrumdisorder |
| _version_ |
1768545407636340736 |