Enhancing a declarative memory in humans: The effect of clonazepam on reconsolidation

A consolidated memory recalled by a specific reminder can become unstable (labile) and susceptible to facilitation or impairment for a discrete period of time. This labilization phase is followed by a process of stabilization called reconsolidation. The phenomenon has been shown in diverse types of...

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Autores principales:	Forcato, Cecilia, Leiguarda, Ramón Héctor, Pedreira, Maria Eugenia
Publicado:	2013
Materias:	Benzodiazepines Memory: declarative/explicit Reconsolidation clonazepam placebo adult anxiety disorder article association controlled study declarative memory drug dose comparison drug mechanism explicit memory facilitation female GABAergic system human human experiment learning male memory consolidation memory reconsolidation normal human priority journal recall short term memory task performance verbal memory Adult Clonazepam Cues Dose-Response Relationship, Drug Female GABA Agonists Humans Male Memory Memory, Long-Term Memory, Short-Term Mental Recall Nootropic Agents Performance-Enhancing Substances Students Verbal Learning Young Adult
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283908_v64_n_p432_Rodriguez http://hdl.handle.net/20.500.12110/paper_00283908_v64_n_p432_Rodriguez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00283908_v64_n_p432_Rodriguez
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spelling	paper:paper_00283908_v64_n_p432_Rodriguez2023-06-08T14:55:10Z Enhancing a declarative memory in humans: The effect of clonazepam on reconsolidation Forcato, Cecilia Leiguarda, Ramón Héctor Pedreira, Maria Eugenia Benzodiazepines Memory: declarative/explicit Reconsolidation clonazepam placebo adult anxiety disorder article association controlled study declarative memory drug dose comparison drug mechanism explicit memory facilitation female GABAergic system human human experiment learning male memory consolidation memory reconsolidation normal human priority journal recall short term memory task performance verbal memory Adult Clonazepam Cues Dose-Response Relationship, Drug Female GABA Agonists Humans Male Memory Memory, Long-Term Memory, Short-Term Mental Recall Nootropic Agents Performance-Enhancing Substances Students Verbal Learning Young Adult A consolidated memory recalled by a specific reminder can become unstable (labile) and susceptible to facilitation or impairment for a discrete period of time. This labilization phase is followed by a process of stabilization called reconsolidation. The phenomenon has been shown in diverse types of memory, and different pharmacological agents have been used to disclose its presence. Several studies have revealed the relevance of the GABAergic system to this process. Consequently, our hypothesis is that the system is involved in the reconsolidation of declarative memory in humans. Thus, using our verbal learning task, we analyzed the effect of benzodiazepines on the re-stabilization of the declarative memory. On Day 1, volunteers learned an association between five cue- response-syllables. On Day 2, the verbal memory was labilized by a reminder presentation, and then a placebo capsule or 0.25 mg or 0.03 mg of clonazepam was administered to the subjects. The verbal memory was evaluated on Day 3. The volunteers who had received the 0.25 mg clonazepam along with the specific reminder on Day 2, exhibited memory improvement. In contrast, there was no effect when the drug was given without retrieval, when the memory was simply retrieved instead of being reactivated or when short-term memory testing was performed 4 h after reactivation. We discuss the GABAergic role in reconsolidation, which shows a collateral effect on other memories when the treatment is aimed at treating anxiety disorders. Further studies might elucidate the role of GABA in the reconsolidation process associated with dissimilar scenarios. This article is part of a Special Issue entitled 'Cognitive Enhancers'. © 2012 Elsevier Ltd. All rights reserved. Fil:Forcato, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Leiguarda, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pedreira, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283908_v64_n_p432_Rodriguez http://hdl.handle.net/20.500.12110/paper_00283908_v64_n_p432_Rodriguez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Benzodiazepines Memory: declarative/explicit Reconsolidation clonazepam placebo adult anxiety disorder article association controlled study declarative memory drug dose comparison drug mechanism explicit memory facilitation female GABAergic system human human experiment learning male memory consolidation memory reconsolidation normal human priority journal recall short term memory task performance verbal memory Adult Clonazepam Cues Dose-Response Relationship, Drug Female GABA Agonists Humans Male Memory Memory, Long-Term Memory, Short-Term Mental Recall Nootropic Agents Performance-Enhancing Substances Students Verbal Learning Young Adult
spellingShingle	Benzodiazepines Memory: declarative/explicit Reconsolidation clonazepam placebo adult anxiety disorder article association controlled study declarative memory drug dose comparison drug mechanism explicit memory facilitation female GABAergic system human human experiment learning male memory consolidation memory reconsolidation normal human priority journal recall short term memory task performance verbal memory Adult Clonazepam Cues Dose-Response Relationship, Drug Female GABA Agonists Humans Male Memory Memory, Long-Term Memory, Short-Term Mental Recall Nootropic Agents Performance-Enhancing Substances Students Verbal Learning Young Adult Forcato, Cecilia Leiguarda, Ramón Héctor Pedreira, Maria Eugenia Enhancing a declarative memory in humans: The effect of clonazepam on reconsolidation
topic_facet	Benzodiazepines Memory: declarative/explicit Reconsolidation clonazepam placebo adult anxiety disorder article association controlled study declarative memory drug dose comparison drug mechanism explicit memory facilitation female GABAergic system human human experiment learning male memory consolidation memory reconsolidation normal human priority journal recall short term memory task performance verbal memory Adult Clonazepam Cues Dose-Response Relationship, Drug Female GABA Agonists Humans Male Memory Memory, Long-Term Memory, Short-Term Mental Recall Nootropic Agents Performance-Enhancing Substances Students Verbal Learning Young Adult
description	A consolidated memory recalled by a specific reminder can become unstable (labile) and susceptible to facilitation or impairment for a discrete period of time. This labilization phase is followed by a process of stabilization called reconsolidation. The phenomenon has been shown in diverse types of memory, and different pharmacological agents have been used to disclose its presence. Several studies have revealed the relevance of the GABAergic system to this process. Consequently, our hypothesis is that the system is involved in the reconsolidation of declarative memory in humans. Thus, using our verbal learning task, we analyzed the effect of benzodiazepines on the re-stabilization of the declarative memory. On Day 1, volunteers learned an association between five cue- response-syllables. On Day 2, the verbal memory was labilized by a reminder presentation, and then a placebo capsule or 0.25 mg or 0.03 mg of clonazepam was administered to the subjects. The verbal memory was evaluated on Day 3. The volunteers who had received the 0.25 mg clonazepam along with the specific reminder on Day 2, exhibited memory improvement. In contrast, there was no effect when the drug was given without retrieval, when the memory was simply retrieved instead of being reactivated or when short-term memory testing was performed 4 h after reactivation. We discuss the GABAergic role in reconsolidation, which shows a collateral effect on other memories when the treatment is aimed at treating anxiety disorders. Further studies might elucidate the role of GABA in the reconsolidation process associated with dissimilar scenarios. This article is part of a Special Issue entitled 'Cognitive Enhancers'. © 2012 Elsevier Ltd. All rights reserved.
author	Forcato, Cecilia Leiguarda, Ramón Héctor Pedreira, Maria Eugenia
author_facet	Forcato, Cecilia Leiguarda, Ramón Héctor Pedreira, Maria Eugenia
author_sort	Forcato, Cecilia
title	Enhancing a declarative memory in humans: The effect of clonazepam on reconsolidation
title_short	Enhancing a declarative memory in humans: The effect of clonazepam on reconsolidation
title_full	Enhancing a declarative memory in humans: The effect of clonazepam on reconsolidation
title_fullStr	Enhancing a declarative memory in humans: The effect of clonazepam on reconsolidation
title_full_unstemmed	Enhancing a declarative memory in humans: The effect of clonazepam on reconsolidation
title_sort	enhancing a declarative memory in humans: the effect of clonazepam on reconsolidation
publishDate	2013
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283908_v64_n_p432_Rodriguez http://hdl.handle.net/20.500.12110/paper_00283908_v64_n_p432_Rodriguez
work_keys_str_mv	AT forcatocecilia enhancingadeclarativememoryinhumanstheeffectofclonazepamonreconsolidation AT leiguardaramonhector enhancingadeclarativememoryinhumanstheeffectofclonazepamonreconsolidation AT pedreiramariaeugenia enhancingadeclarativememoryinhumanstheeffectofclonazepamonreconsolidation
_version_	1768544215051010048

Enhancing a declarative memory in humans: The effect of clonazepam on reconsolidation

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