Role of the sympathetic nervous system in the control of thyroid compensatory growth of normal and hypophysectomized rats1
Compensatory thyroid growth in rats subjected to unilateral thyroidectomy (Tx) and superior cervical ganglionectomy (SCGx) performed ipsilaterally to the remaining lobe was about 2-fold that of rats subjected hemiTx alone, when assessed 7-15 days after surgery. HemiTx depressed serum T<inf>4&l...
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1985
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v40_n4_p309_Romeo http://hdl.handle.net/20.500.12110/paper_00283835_v40_n4_p309_Romeo |
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paper:paper_00283835_v40_n4_p309_Romeo2023-06-08T14:54:59Z Role of the sympathetic nervous system in the control of thyroid compensatory growth of normal and hypophysectomized rats1 Compensatory hypertrophy Pituitary gland Sympathetic superior cervical ganglion T<inf>4</inf> TSH thyrotropin thyroxine adrenergic system animal experiment autonomic nervous system endocrine system etiology hemithyroidectomy hypophysis nonhuman peripheral nervous system priority journal rat superior cervical ganglion Animal Female Ganglia, Sympathetic Hyperplasia Hypophysectomy Male Pituitary Gland Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroidectomy Thyrotropin Thyroxine Compensatory thyroid growth in rats subjected to unilateral thyroidectomy (Tx) and superior cervical ganglionectomy (SCGx) performed ipsilaterally to the remaining lobe was about 2-fold that of rats subjected hemiTx alone, when assessed 7-15 days after surgery. HemiTx depressed serum T<inf>4</inf> levels by 33% and increased serum TSH by 80% in control rats. Unilateral SCGx, which did not affect circulating T<inf>4</inf> or TSH by itself, prevented hemiTx-induced changes of hormone levels. After hypophysectomy (Hpx) thyroid involution ensued. The subsequent hemiTx of Hpx rats did not affect Hpx-induced thyroid regression 7 days later, but abolished it 15 days later. At this time a factorial analysis of variance revealed lack of significant interaction between Hpx and hemiTx thus suggesting that a similar thyroid growth ensues after hemiTx regardless of pituitary intactness. However, both serum T<inf>4</inf> and TSH levels were very low in Hpx rats regardless of whether one or two thyroid lobes were present indicating that thyroid growth in the absence of pituitary was not accompanied by increased secretory activity. SCGx performed ipsilaterally to the remaining lobe blunted the growth of the lobe in Hpx hemiTx rats. Moreover, the denervated thyroid lobe regressed in Hpx rats to values significantly lower than those of Hpx rats having intact sympathetic nerves both in the presence or in the absence of a contralateral thyroid lobe. SCGx did not modify the very low serum TSH and T<inf>4</inf> levels of Hpx rats. These results indicate that (1) in rats with intact pituitaries ipsilateral SCGx amplifies the compensatory growth and increases T<inf>4</inf> secretion of the remaining lobe after hemi Tx; (2) in Hpx rats ipsilateral SCGx blunted the growth that follows unilateral Tx and induces further regression of the denervated lobe regardless of whether a contralateral lobe is present or not. © 1985 S. Karger AG, Basel. 1985 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v40_n4_p309_Romeo http://hdl.handle.net/20.500.12110/paper_00283835_v40_n4_p309_Romeo |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Compensatory hypertrophy Pituitary gland Sympathetic superior cervical ganglion T<inf>4</inf> TSH thyrotropin thyroxine adrenergic system animal experiment autonomic nervous system endocrine system etiology hemithyroidectomy hypophysis nonhuman peripheral nervous system priority journal rat superior cervical ganglion Animal Female Ganglia, Sympathetic Hyperplasia Hypophysectomy Male Pituitary Gland Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroidectomy Thyrotropin Thyroxine |
| spellingShingle |
Compensatory hypertrophy Pituitary gland Sympathetic superior cervical ganglion T<inf>4</inf> TSH thyrotropin thyroxine adrenergic system animal experiment autonomic nervous system endocrine system etiology hemithyroidectomy hypophysis nonhuman peripheral nervous system priority journal rat superior cervical ganglion Animal Female Ganglia, Sympathetic Hyperplasia Hypophysectomy Male Pituitary Gland Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroidectomy Thyrotropin Thyroxine Role of the sympathetic nervous system in the control of thyroid compensatory growth of normal and hypophysectomized rats1 |
| topic_facet |
Compensatory hypertrophy Pituitary gland Sympathetic superior cervical ganglion T<inf>4</inf> TSH thyrotropin thyroxine adrenergic system animal experiment autonomic nervous system endocrine system etiology hemithyroidectomy hypophysis nonhuman peripheral nervous system priority journal rat superior cervical ganglion Animal Female Ganglia, Sympathetic Hyperplasia Hypophysectomy Male Pituitary Gland Rats Rats, Inbred Strains Support, Non-U.S. Gov't Thyroid Gland Thyroidectomy Thyrotropin Thyroxine |
| description |
Compensatory thyroid growth in rats subjected to unilateral thyroidectomy (Tx) and superior cervical ganglionectomy (SCGx) performed ipsilaterally to the remaining lobe was about 2-fold that of rats subjected hemiTx alone, when assessed 7-15 days after surgery. HemiTx depressed serum T<inf>4</inf> levels by 33% and increased serum TSH by 80% in control rats. Unilateral SCGx, which did not affect circulating T<inf>4</inf> or TSH by itself, prevented hemiTx-induced changes of hormone levels. After hypophysectomy (Hpx) thyroid involution ensued. The subsequent hemiTx of Hpx rats did not affect Hpx-induced thyroid regression 7 days later, but abolished it 15 days later. At this time a factorial analysis of variance revealed lack of significant interaction between Hpx and hemiTx thus suggesting that a similar thyroid growth ensues after hemiTx regardless of pituitary intactness. However, both serum T<inf>4</inf> and TSH levels were very low in Hpx rats regardless of whether one or two thyroid lobes were present indicating that thyroid growth in the absence of pituitary was not accompanied by increased secretory activity. SCGx performed ipsilaterally to the remaining lobe blunted the growth of the lobe in Hpx hemiTx rats. Moreover, the denervated thyroid lobe regressed in Hpx rats to values significantly lower than those of Hpx rats having intact sympathetic nerves both in the presence or in the absence of a contralateral thyroid lobe. SCGx did not modify the very low serum TSH and T<inf>4</inf> levels of Hpx rats. These results indicate that (1) in rats with intact pituitaries ipsilateral SCGx amplifies the compensatory growth and increases T<inf>4</inf> secretion of the remaining lobe after hemi Tx; (2) in Hpx rats ipsilateral SCGx blunted the growth that follows unilateral Tx and induces further regression of the denervated lobe regardless of whether a contralateral lobe is present or not. © 1985 S. Karger AG, Basel. |
| title |
Role of the sympathetic nervous system in the control of thyroid compensatory growth of normal and hypophysectomized rats1 |
| title_short |
Role of the sympathetic nervous system in the control of thyroid compensatory growth of normal and hypophysectomized rats1 |
| title_full |
Role of the sympathetic nervous system in the control of thyroid compensatory growth of normal and hypophysectomized rats1 |
| title_fullStr |
Role of the sympathetic nervous system in the control of thyroid compensatory growth of normal and hypophysectomized rats1 |
| title_full_unstemmed |
Role of the sympathetic nervous system in the control of thyroid compensatory growth of normal and hypophysectomized rats1 |
| title_sort |
role of the sympathetic nervous system in the control of thyroid compensatory growth of normal and hypophysectomized rats1 |
| publishDate |
1985 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v40_n4_p309_Romeo http://hdl.handle.net/20.500.12110/paper_00283835_v40_n4_p309_Romeo |
| _version_ |
1768545543405961216 |