DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation

During development of the rat anterior pituitary gland (APG) there is a fall in DNA replication which is accompanied by a decline in the activity of the soluble DNA polymerase and of an endonuclease. This latter enzyme is capable of activating the DNA template for the DNA polymerase assay. Sulpiride...

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Detalles Bibliográficos
Publicado: 1979
Materias:
DNA synthesis
Pituitary gland
Prolactin
Sulpiride
dna polymerase
endonuclease
prolactin
sulpiride
thymidine kinase
adenohypophysis
animal experiment
dna synthesis
endocrine system
hypophysis
rat
Aging
Animals
Deoxyribonucleases
DNA
DNA Replication
DNA-Directed DNA Polymerase
Endonucleases
Pituitary Gland, Anterior
Rats
Thymidine Kinase
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v29_n1_p42_Kalbermann
http://hdl.handle.net/20.500.12110/paper_00283835_v29_n1_p42_Kalbermann
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_00283835_v29_n1_p42_Kalbermann
record_format dspace
spelling paper:paper_00283835_v29_n1_p42_Kalbermann2023-06-08T14:54:57Z DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation DNA synthesis Pituitary gland Prolactin Sulpiride dna polymerase endonuclease prolactin sulpiride thymidine kinase adenohypophysis animal experiment dna synthesis endocrine system hypophysis rat Aging Animals Deoxyribonucleases DNA DNA Replication DNA-Directed DNA Polymerase Endonucleases Pituitary Gland, Anterior Rats Sulpiride Thymidine Kinase During development of the rat anterior pituitary gland (APG) there is a fall in DNA replication which is accompanied by a decline in the activity of the soluble DNA polymerase and of an endonuclease. This latter enzyme is capable of activating the DNA template for the DNA polymerase assay. Sulpiride sulfate, a drug known to produce prolactin release from the APG, increases thymidine incorporation in the APG 20 h after the injection. This drug also enhances the activity of the soluble DNA polymerase while that of the endonuclease and thymidine kinase does not change. The results suggest that the intracellular prolactin content regulates DNA replication in mammotrophs and that the soluble DNA polymerase plays an important role in this regulation. © 1979 S. Karger AG, Basel. 1979 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v29_n1_p42_Kalbermann http://hdl.handle.net/20.500.12110/paper_00283835_v29_n1_p42_Kalbermann
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic DNA synthesis
Pituitary gland
Prolactin
Sulpiride
dna polymerase
endonuclease
prolactin
sulpiride
thymidine kinase
adenohypophysis
animal experiment
dna synthesis
endocrine system
hypophysis
rat
Aging
Animals
Deoxyribonucleases
DNA
DNA Replication
DNA-Directed DNA Polymerase
Endonucleases
Pituitary Gland, Anterior
Rats
Sulpiride
Thymidine Kinase
spellingShingle DNA synthesis
Pituitary gland
Prolactin
Sulpiride
dna polymerase
endonuclease
prolactin
sulpiride
thymidine kinase
adenohypophysis
animal experiment
dna synthesis
endocrine system
hypophysis
rat
Aging
Animals
Deoxyribonucleases
DNA
DNA Replication
DNA-Directed DNA Polymerase
Endonucleases
Pituitary Gland, Anterior
Rats
Sulpiride
Thymidine Kinase
DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation
topic_facet DNA synthesis
Pituitary gland
Prolactin
Sulpiride
dna polymerase
endonuclease
prolactin
sulpiride
thymidine kinase
adenohypophysis
animal experiment
dna synthesis
endocrine system
hypophysis
rat
Aging
Animals
Deoxyribonucleases
DNA
DNA Replication
DNA-Directed DNA Polymerase
Endonucleases
Pituitary Gland, Anterior
Rats
Sulpiride
Thymidine Kinase
description During development of the rat anterior pituitary gland (APG) there is a fall in DNA replication which is accompanied by a decline in the activity of the soluble DNA polymerase and of an endonuclease. This latter enzyme is capable of activating the DNA template for the DNA polymerase assay. Sulpiride sulfate, a drug known to produce prolactin release from the APG, increases thymidine incorporation in the APG 20 h after the injection. This drug also enhances the activity of the soluble DNA polymerase while that of the endonuclease and thymidine kinase does not change. The results suggest that the intracellular prolactin content regulates DNA replication in mammotrophs and that the soluble DNA polymerase plays an important role in this regulation. © 1979 S. Karger AG, Basel.
title DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation
title_short DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation
title_full DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation
title_fullStr DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation
title_full_unstemmed DNA synthesis in the pituitary gland of the rat: Effect of sulpiride and postnatal maturation
title_sort dna synthesis in the pituitary gland of the rat: effect of sulpiride and postnatal maturation
publishDate 1979
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283835_v29_n1_p42_Kalbermann
http://hdl.handle.net/20.500.12110/paper_00283835_v29_n1_p42_Kalbermann
_version_ 1768544720770826240

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