Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis

Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those fromEurope, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Co...

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Autor principal:	Zumárraga, Martín José
Publicado:	2014
Materias:	adaptation bacterium common ancestry disease spread disease transmission genome geographical distribution Holocene pinniped Pleistocene skeleton tuberculosis Article bacterial genome bacterial transmission bacterium identification DNA damage DNA library human human tissue mutation rate Mycobacterium tuberculosis nonhuman Peruvian phylogeny population size priority journal single nucleotide polymorphism animal bone ethnology Europe genetics genomics history microbiology migration Peru seal transmission zoonosis Pinnipedia United States Mammalia Otariidae Animals Bone and Bones Genome, Bacterial Genomics History, Ancient Human Migration Humans Phylogeny Tuberculosis Zoonoses
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00280836_v514_n7253_p494_Bos http://hdl.handle.net/20.500.12110/paper_00280836_v514_n7253_p494_Bos
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00280836_v514_n7253_p494_Bos
record_format	dspace
spelling	paper:paper_00280836_v514_n7253_p494_Bos2023-06-08T14:54:46Z Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis Zumárraga, Martín José adaptation bacterium common ancestry disease spread disease transmission genome geographical distribution Holocene pinniped Pleistocene skeleton tuberculosis Article bacterial genome bacterial transmission bacterium identification DNA damage DNA library Holocene human human tissue mutation rate Mycobacterium tuberculosis nonhuman Peruvian phylogeny population size priority journal single nucleotide polymorphism tuberculosis animal bacterial genome bone ethnology Europe genetics genomics history microbiology migration Mycobacterium tuberculosis Peru seal transmission tuberculosis zoonosis Pinnipedia Europe United States Mammalia Mycobacterium tuberculosis Otariidae Animals Bone and Bones Europe Genome, Bacterial Genomics History, Ancient Human Migration Humans Mycobacterium tuberculosis Peru Phylogeny Pinnipedia Tuberculosis Zoonoses Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those fromEurope, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch3, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-oldmycobacterial genomesfromPeruvianhuman skeletons, revealing that amember of the M. tuberculosis complex caused human disease before contact.The ancient strains are distinct fromknownhuman-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean. © 2014 Macmillan Publishers Limited. All rights reserved. Fil:Zumarraga, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00280836_v514_n7253_p494_Bos http://hdl.handle.net/20.500.12110/paper_00280836_v514_n7253_p494_Bos
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	adaptation bacterium common ancestry disease spread disease transmission genome geographical distribution Holocene pinniped Pleistocene skeleton tuberculosis Article bacterial genome bacterial transmission bacterium identification DNA damage DNA library Holocene human human tissue mutation rate Mycobacterium tuberculosis nonhuman Peruvian phylogeny population size priority journal single nucleotide polymorphism tuberculosis animal bacterial genome bone ethnology Europe genetics genomics history microbiology migration Mycobacterium tuberculosis Peru seal transmission tuberculosis zoonosis Pinnipedia Europe United States Mammalia Mycobacterium tuberculosis Otariidae Animals Bone and Bones Europe Genome, Bacterial Genomics History, Ancient Human Migration Humans Mycobacterium tuberculosis Peru Phylogeny Pinnipedia Tuberculosis Zoonoses
spellingShingle	adaptation bacterium common ancestry disease spread disease transmission genome geographical distribution Holocene pinniped Pleistocene skeleton tuberculosis Article bacterial genome bacterial transmission bacterium identification DNA damage DNA library Holocene human human tissue mutation rate Mycobacterium tuberculosis nonhuman Peruvian phylogeny population size priority journal single nucleotide polymorphism tuberculosis animal bacterial genome bone ethnology Europe genetics genomics history microbiology migration Mycobacterium tuberculosis Peru seal transmission tuberculosis zoonosis Pinnipedia Europe United States Mammalia Mycobacterium tuberculosis Otariidae Animals Bone and Bones Europe Genome, Bacterial Genomics History, Ancient Human Migration Humans Mycobacterium tuberculosis Peru Phylogeny Pinnipedia Tuberculosis Zoonoses Zumárraga, Martín José Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis
topic_facet	adaptation bacterium common ancestry disease spread disease transmission genome geographical distribution Holocene pinniped Pleistocene skeleton tuberculosis Article bacterial genome bacterial transmission bacterium identification DNA damage DNA library Holocene human human tissue mutation rate Mycobacterium tuberculosis nonhuman Peruvian phylogeny population size priority journal single nucleotide polymorphism tuberculosis animal bacterial genome bone ethnology Europe genetics genomics history microbiology migration Mycobacterium tuberculosis Peru seal transmission tuberculosis zoonosis Pinnipedia Europe United States Mammalia Mycobacterium tuberculosis Otariidae Animals Bone and Bones Europe Genome, Bacterial Genomics History, Ancient Human Migration Humans Mycobacterium tuberculosis Peru Phylogeny Pinnipedia Tuberculosis Zoonoses
description	Modern strains of Mycobacterium tuberculosis from the Americas are closely related to those fromEurope, supporting the assumption that human tuberculosis was introduced post-contact1. This notion, however, is incompatible with archaeological evidence of pre-contact tuberculosis in the New World2. Comparative genomics of modern isolates suggests that M. tuberculosis attained its worldwide distribution following human dispersals out of Africa during the Pleistocene epoch3, although this has yet to be confirmed with ancient calibration points. Here we present three 1,000-year-oldmycobacterial genomesfromPeruvianhuman skeletons, revealing that amember of the M. tuberculosis complex caused human disease before contact.The ancient strains are distinct fromknownhuman-adapted forms and are most closely related to those adapted to seals and sea lions. Two independent dating approaches suggest a most recent common ancestor for the M. tuberculosis complex less than 6,000 years ago, which supports a Holocene dispersal of the disease. Our results implicate sea mammals as having played a role in transmitting the disease to humans across the ocean. © 2014 Macmillan Publishers Limited. All rights reserved.
author	Zumárraga, Martín José
author_facet	Zumárraga, Martín José
author_sort	Zumárraga, Martín José
title	Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis
title_short	Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis
title_full	Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis
title_fullStr	Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis
title_full_unstemmed	Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis
title_sort	pre-columbian mycobacterial genomes reveal seals as a source of new world human tuberculosis
publishDate	2014
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00280836_v514_n7253_p494_Bos http://hdl.handle.net/20.500.12110/paper_00280836_v514_n7253_p494_Bos
work_keys_str_mv	AT zumarragamartinjose precolumbianmycobacterialgenomesrevealsealsasasourceofnewworldhumantuberculosis
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Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis

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