Behavioral tagging is a general mechanism of long-term memory formation
In daily life, memories are intertwined events. Little is known about the mechanisms involved in their interactions. Using two hippocampus-dependent (spatial object recognition and contextual fear conditioning) and one hippocampus-independent (conditioned taste aversion) learning tasks, we show that...
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2009
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paper:paper_00278424_v106_n34_p14599_Ballarini2023-06-08T14:54:23Z Behavioral tagging is a general mechanism of long-term memory formation Moncada, Diego Martínez, María Cecilia Alen, Nadia Viola, Haydée Ana María Hippocampus Insular cortex Memory consolidation Novelty Protein synthesis animal experiment article behavior conditioned reflex conditioning controlled study hippocampus learning long term memory male nonhuman open field behavior priority journal protein synthesis rat recognition short term memory task performance taste aversion training Animals Behavior, Animal Conditioning (Psychology) Discrimination Learning Fear Hippocampus Learning Long-Term Potentiation Male Memory Memory, Short-Term Neocortex Neuronal Plasticity Psychomotor Performance Rats Rats, Wistar Saccharin Sodium Chloride Spatial Behavior Taste Time Factors Rattus In daily life, memories are intertwined events. Little is known about the mechanisms involved in their interactions. Using two hippocampus-dependent (spatial object recognition and contextual fear conditioning) and one hippocampus-independent (conditioned taste aversion) learning tasks, we show that in rats subjected to weak training protocols that induce solely short term memory (STM), long term memory (LTM) is promoted and formed only if training sessions took place in contingence with a novel, but not familiar, experience occurring during a critical time window around training. This process requires newly synthesized proteins induced by novelty and reveals a general mechanism of LTM formation that begins with the setting of a "learning tag" established by a weak training. These findings represent the first comprehensive set of evidences indicating the existence of a behavioral tagging process that in analogy to the synaptic tagging and capture process, need the creation of a transient, protein synthesis-independent, and input specific tag. Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Martinez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Alen, N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v106_n34_p14599_Ballarini http://hdl.handle.net/20.500.12110/paper_00278424_v106_n34_p14599_Ballarini |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Hippocampus Insular cortex Memory consolidation Novelty Protein synthesis animal experiment article behavior conditioned reflex conditioning controlled study hippocampus learning long term memory male nonhuman open field behavior priority journal protein synthesis rat recognition short term memory task performance taste aversion training Animals Behavior, Animal Conditioning (Psychology) Discrimination Learning Fear Hippocampus Learning Long-Term Potentiation Male Memory Memory, Short-Term Neocortex Neuronal Plasticity Psychomotor Performance Rats Rats, Wistar Saccharin Sodium Chloride Spatial Behavior Taste Time Factors Rattus |
| spellingShingle |
Hippocampus Insular cortex Memory consolidation Novelty Protein synthesis animal experiment article behavior conditioned reflex conditioning controlled study hippocampus learning long term memory male nonhuman open field behavior priority journal protein synthesis rat recognition short term memory task performance taste aversion training Animals Behavior, Animal Conditioning (Psychology) Discrimination Learning Fear Hippocampus Learning Long-Term Potentiation Male Memory Memory, Short-Term Neocortex Neuronal Plasticity Psychomotor Performance Rats Rats, Wistar Saccharin Sodium Chloride Spatial Behavior Taste Time Factors Rattus Moncada, Diego Martínez, María Cecilia Alen, Nadia Viola, Haydée Ana María Behavioral tagging is a general mechanism of long-term memory formation |
| topic_facet |
Hippocampus Insular cortex Memory consolidation Novelty Protein synthesis animal experiment article behavior conditioned reflex conditioning controlled study hippocampus learning long term memory male nonhuman open field behavior priority journal protein synthesis rat recognition short term memory task performance taste aversion training Animals Behavior, Animal Conditioning (Psychology) Discrimination Learning Fear Hippocampus Learning Long-Term Potentiation Male Memory Memory, Short-Term Neocortex Neuronal Plasticity Psychomotor Performance Rats Rats, Wistar Saccharin Sodium Chloride Spatial Behavior Taste Time Factors Rattus |
| description |
In daily life, memories are intertwined events. Little is known about the mechanisms involved in their interactions. Using two hippocampus-dependent (spatial object recognition and contextual fear conditioning) and one hippocampus-independent (conditioned taste aversion) learning tasks, we show that in rats subjected to weak training protocols that induce solely short term memory (STM), long term memory (LTM) is promoted and formed only if training sessions took place in contingence with a novel, but not familiar, experience occurring during a critical time window around training. This process requires newly synthesized proteins induced by novelty and reveals a general mechanism of LTM formation that begins with the setting of a "learning tag" established by a weak training. These findings represent the first comprehensive set of evidences indicating the existence of a behavioral tagging process that in analogy to the synaptic tagging and capture process, need the creation of a transient, protein synthesis-independent, and input specific tag. |
| author |
Moncada, Diego Martínez, María Cecilia Alen, Nadia Viola, Haydée Ana María |
| author_facet |
Moncada, Diego Martínez, María Cecilia Alen, Nadia Viola, Haydée Ana María |
| author_sort |
Moncada, Diego |
| title |
Behavioral tagging is a general mechanism of long-term memory formation |
| title_short |
Behavioral tagging is a general mechanism of long-term memory formation |
| title_full |
Behavioral tagging is a general mechanism of long-term memory formation |
| title_fullStr |
Behavioral tagging is a general mechanism of long-term memory formation |
| title_full_unstemmed |
Behavioral tagging is a general mechanism of long-term memory formation |
| title_sort |
behavioral tagging is a general mechanism of long-term memory formation |
| publishDate |
2009 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v106_n34_p14599_Ballarini http://hdl.handle.net/20.500.12110/paper_00278424_v106_n34_p14599_Ballarini |
| work_keys_str_mv |
AT moncadadiego behavioraltaggingisageneralmechanismoflongtermmemoryformation AT martinezmariacecilia behavioraltaggingisageneralmechanismoflongtermmemoryformation AT alennadia behavioraltaggingisageneralmechanismoflongtermmemoryformation AT violahaydeeanamaria behavioraltaggingisageneralmechanismoflongtermmemoryformation |
| _version_ |
1768545317505990656 |