Blood parameters variation in Calomys musculinus infected with Junin virus, strain XJCl3

The aim of this study was to analyze the alterations in homeostasis induced by Junin virus during acute and persistent infection of C. musculinus. Virus presence in brain, hematological response and glycemia levels were evaluated. Newborn C. musculinus inoculated with 4000 DL50 of Junin virus, strai...

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Autores principales:	Steyerthal, Noemí Lucía, Lampuri, Jorge Salvador, Coto, Celia Esther
Publicado:	1990
Materias:	analysis of variance animal Arenavirus article Arvicolinae blood glucose blood level isolation and purification microbiology mouse serodiagnosis virus hemorrhagic fever Analysis of Variance Animals Arenaviruses, New World Blood Glucose Hemorrhagic Fever, American Mice Neutralization Tests
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v50_n4_p335_Steyerthal http://hdl.handle.net/20.500.12110/paper_00257680_v50_n4_p335_Steyerthal
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00257680_v50_n4_p335_Steyerthal
record_format	dspace
spelling	paper:paper_00257680_v50_n4_p335_Steyerthal2023-06-08T14:53:26Z Blood parameters variation in Calomys musculinus infected with Junin virus, strain XJCl3 Steyerthal, Noemí Lucía Lampuri, Jorge Salvador Coto, Celia Esther analysis of variance animal Arenavirus article Arvicolinae blood glucose blood level isolation and purification microbiology mouse serodiagnosis virus hemorrhagic fever Analysis of Variance Animals Arenaviruses, New World Arvicolinae Blood Glucose Hemorrhagic Fever, American Mice Neutralization Tests The aim of this study was to analyze the alterations in homeostasis induced by Junin virus during acute and persistent infection of C. musculinus. Virus presence in brain, hematological response and glycemia levels were evaluated. Newborn C. musculinus inoculated with 4000 DL50 of Junin virus, strain XJCl3 by intraperitoneal route developed a typical acute disease, with 50-70% mortality. Virus was isolated from brain starting day 6 post-infection (Fig. 1) and the peak titer (10(8) DL50/ml) was reached at 12 days post-infection. Neutralizing anti-Junin virus antibodies were detected from day 11 post-infection and all chronically infected animals developed persistent levels of neutralizing antibodies. In the acute stage of infection, 40% of the animals developed lymphopenia and neutrophilia (Fig. 2) while a slight variation was observed in the monocyte population. An important hypoglycemia was also seen in the acute infection (mean = 3.52 mmol/l) in comparison with control values (mean = 6.21 mmol/l), p less than 0.01 (Fig. 3). By contrast during the chronic stage of infection, neither hematological parameters (Table 2) varied between infected and control animals. Fil:Steyerthal, N.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Lampuri, J.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Coto, C.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1990 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v50_n4_p335_Steyerthal http://hdl.handle.net/20.500.12110/paper_00257680_v50_n4_p335_Steyerthal
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	analysis of variance animal Arenavirus article Arvicolinae blood glucose blood level isolation and purification microbiology mouse serodiagnosis virus hemorrhagic fever Analysis of Variance Animals Arenaviruses, New World Arvicolinae Blood Glucose Hemorrhagic Fever, American Mice Neutralization Tests
spellingShingle	analysis of variance animal Arenavirus article Arvicolinae blood glucose blood level isolation and purification microbiology mouse serodiagnosis virus hemorrhagic fever Analysis of Variance Animals Arenaviruses, New World Arvicolinae Blood Glucose Hemorrhagic Fever, American Mice Neutralization Tests Steyerthal, Noemí Lucía Lampuri, Jorge Salvador Coto, Celia Esther Blood parameters variation in Calomys musculinus infected with Junin virus, strain XJCl3
topic_facet	analysis of variance animal Arenavirus article Arvicolinae blood glucose blood level isolation and purification microbiology mouse serodiagnosis virus hemorrhagic fever Analysis of Variance Animals Arenaviruses, New World Arvicolinae Blood Glucose Hemorrhagic Fever, American Mice Neutralization Tests
description	The aim of this study was to analyze the alterations in homeostasis induced by Junin virus during acute and persistent infection of C. musculinus. Virus presence in brain, hematological response and glycemia levels were evaluated. Newborn C. musculinus inoculated with 4000 DL50 of Junin virus, strain XJCl3 by intraperitoneal route developed a typical acute disease, with 50-70% mortality. Virus was isolated from brain starting day 6 post-infection (Fig. 1) and the peak titer (10(8) DL50/ml) was reached at 12 days post-infection. Neutralizing anti-Junin virus antibodies were detected from day 11 post-infection and all chronically infected animals developed persistent levels of neutralizing antibodies. In the acute stage of infection, 40% of the animals developed lymphopenia and neutrophilia (Fig. 2) while a slight variation was observed in the monocyte population. An important hypoglycemia was also seen in the acute infection (mean = 3.52 mmol/l) in comparison with control values (mean = 6.21 mmol/l), p less than 0.01 (Fig. 3). By contrast during the chronic stage of infection, neither hematological parameters (Table 2) varied between infected and control animals.
author	Steyerthal, Noemí Lucía Lampuri, Jorge Salvador Coto, Celia Esther
author_facet	Steyerthal, Noemí Lucía Lampuri, Jorge Salvador Coto, Celia Esther
author_sort	Steyerthal, Noemí Lucía
title	Blood parameters variation in Calomys musculinus infected with Junin virus, strain XJCl3
title_short	Blood parameters variation in Calomys musculinus infected with Junin virus, strain XJCl3
title_full	Blood parameters variation in Calomys musculinus infected with Junin virus, strain XJCl3
title_fullStr	Blood parameters variation in Calomys musculinus infected with Junin virus, strain XJCl3
title_full_unstemmed	Blood parameters variation in Calomys musculinus infected with Junin virus, strain XJCl3
title_sort	blood parameters variation in calomys musculinus infected with junin virus, strain xjcl3
publishDate	1990
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v50_n4_p335_Steyerthal http://hdl.handle.net/20.500.12110/paper_00257680_v50_n4_p335_Steyerthal
work_keys_str_mv	AT steyerthalnoemilucia bloodparametersvariationincalomysmusculinusinfectedwithjuninvirusstrainxjcl3 AT lampurijorgesalvador bloodparametersvariationincalomysmusculinusinfectedwithjuninvirusstrainxjcl3 AT cotoceliaesther bloodparametersvariationincalomysmusculinusinfectedwithjuninvirusstrainxjcl3
_version_	1768546573225033728

Blood parameters variation in Calomys musculinus infected with Junin virus, strain XJCl3

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