Mechanisms of action of endothelin-i in rat adrenal

Displacement curves of 125I-Endothelin-1 (ET-1) binding to rat adrenal cells with unlabeled ET-1, and the ET-1 receptor-related peptides sarafotoxin and BQ-123, show that rat adrenal cortex possess, as its bovine counterpart, two different receptors to ET-1 named ET-A and ET-B. Binding of ET-1 to it...

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Publicado:	1998
Materias:	Adrenal cells Aldosterone Endothelin-1 1 (5 isoquinolinesulfonyl) 2 methylpiperazine aldosterone calcium 45 calcium channel corticotropin cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl) endothelin 1 endothelin A receptor endothelin B receptor iodine 125 ouabain sarafotoxin S6b adrenal cortex adrenal gland animal tissue article controlled study negative feedback nonhuman rat renin angiotensin aldosterone system zona glomerulosa
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v63_n15_p1315_Pecci http://hdl.handle.net/20.500.12110/paper_00243205_v63_n15_p1315_Pecci
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00243205_v63_n15_p1315_Pecci
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spelling	paper:paper_00243205_v63_n15_p1315_Pecci2023-06-08T14:52:02Z Mechanisms of action of endothelin-i in rat adrenal Adrenal cells Aldosterone Endothelin-1 1 (5 isoquinolinesulfonyl) 2 methylpiperazine aldosterone calcium 45 calcium channel corticotropin cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl) endothelin 1 endothelin A receptor endothelin B receptor iodine 125 ouabain sarafotoxin S6b adrenal cortex adrenal gland animal tissue article controlled study negative feedback nonhuman rat renin angiotensin aldosterone system zona glomerulosa Displacement curves of 125I-Endothelin-1 (ET-1) binding to rat adrenal cells with unlabeled ET-1, and the ET-1 receptor-related peptides sarafotoxin and BQ-123, show that rat adrenal cortex possess, as its bovine counterpart, two different receptors to ET-1 named ET-A and ET-B. Binding of ET-1 to its rat adrenal receptors stimulates i) aldosterone production, in vivo and in vitro ii) calcium influx, which is mediated through voltage dependent- and receptor operated- calcium channels, iii) cholesterol uptake, iv) stimulation of Na+/K+-ATPase and iv) diacylglycerol production. While the last effect is mediated through ET-A receptors the others involve binding of ET-1 to ET-B receptors. Finally, ouabain potentiates the ET-1-mediated stimulation of aldosterone production, suggesting that the effect of the peptidic hormone on Na+/K+-ATPase could act as a negative feedback mechanism. 1998 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v63_n15_p1315_Pecci http://hdl.handle.net/20.500.12110/paper_00243205_v63_n15_p1315_Pecci
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Adrenal cells Aldosterone Endothelin-1 1 (5 isoquinolinesulfonyl) 2 methylpiperazine aldosterone calcium 45 calcium channel corticotropin cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl) endothelin 1 endothelin A receptor endothelin B receptor iodine 125 ouabain sarafotoxin S6b adrenal cortex adrenal gland animal tissue article controlled study negative feedback nonhuman rat renin angiotensin aldosterone system zona glomerulosa
spellingShingle	Adrenal cells Aldosterone Endothelin-1 1 (5 isoquinolinesulfonyl) 2 methylpiperazine aldosterone calcium 45 calcium channel corticotropin cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl) endothelin 1 endothelin A receptor endothelin B receptor iodine 125 ouabain sarafotoxin S6b adrenal cortex adrenal gland animal tissue article controlled study negative feedback nonhuman rat renin angiotensin aldosterone system zona glomerulosa Mechanisms of action of endothelin-i in rat adrenal
topic_facet	Adrenal cells Aldosterone Endothelin-1 1 (5 isoquinolinesulfonyl) 2 methylpiperazine aldosterone calcium 45 calcium channel corticotropin cyclo(dextro tryptophyl dextro aspartylprolyl dextro valylleucyl) endothelin 1 endothelin A receptor endothelin B receptor iodine 125 ouabain sarafotoxin S6b adrenal cortex adrenal gland animal tissue article controlled study negative feedback nonhuman rat renin angiotensin aldosterone system zona glomerulosa
description	Displacement curves of 125I-Endothelin-1 (ET-1) binding to rat adrenal cells with unlabeled ET-1, and the ET-1 receptor-related peptides sarafotoxin and BQ-123, show that rat adrenal cortex possess, as its bovine counterpart, two different receptors to ET-1 named ET-A and ET-B. Binding of ET-1 to its rat adrenal receptors stimulates i) aldosterone production, in vivo and in vitro ii) calcium influx, which is mediated through voltage dependent- and receptor operated- calcium channels, iii) cholesterol uptake, iv) stimulation of Na+/K+-ATPase and iv) diacylglycerol production. While the last effect is mediated through ET-A receptors the others involve binding of ET-1 to ET-B receptors. Finally, ouabain potentiates the ET-1-mediated stimulation of aldosterone production, suggesting that the effect of the peptidic hormone on Na+/K+-ATPase could act as a negative feedback mechanism.
title	Mechanisms of action of endothelin-i in rat adrenal
title_short	Mechanisms of action of endothelin-i in rat adrenal
title_full	Mechanisms of action of endothelin-i in rat adrenal
title_fullStr	Mechanisms of action of endothelin-i in rat adrenal
title_full_unstemmed	Mechanisms of action of endothelin-i in rat adrenal
title_sort	mechanisms of action of endothelin-i in rat adrenal
publishDate	1998
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v63_n15_p1315_Pecci http://hdl.handle.net/20.500.12110/paper_00243205_v63_n15_p1315_Pecci
_version_	1768546480031793152

Mechanisms of action of endothelin-i in rat adrenal

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