Sensitivity of human peripheral blood mononuclear leukocytes to visible light

Overnight light exposure of cultured human peripheral blood mononuclear leukocytes [PBML], significantly increased basal [3H]thymidine incorporation and upon stimulation with phytohemagglutinin [PHA]. Melatonin (10-9 to 10-5 M) enhanced the light-induced increase of [3H]thymidine incorporation, whil...

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Autores principales:	Finocchiaro, Liliana María Elena, Glikin, Gerardo Claudio
Publicado:	1995
Materias:	melatonin peripheral blood mononuclear leukocytes serotonin visible light 5 hydroxyindoleacetic acid phytohemagglutinin thymidine thymidine h 3 unclassified drug article controlled study dna replication dna synthesis human human cell light membrane binding monocyte Base Sequence Cells, Cultured DNA DNA Primers Gene Expression Human In Vitro Indoles Leukocytes, Mononuclear Light Melatonin Molecular Sequence Data Opsin Serotonin Support, Non-U.S. Gov't
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v57_n11_p1097_Finocchiaro http://hdl.handle.net/20.500.12110/paper_00243205_v57_n11_p1097_Finocchiaro
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00243205_v57_n11_p1097_Finocchiaro
record_format	dspace
spelling	paper:paper_00243205_v57_n11_p1097_Finocchiaro2025-07-30T17:33:42Z Sensitivity of human peripheral blood mononuclear leukocytes to visible light Finocchiaro, Liliana María Elena Glikin, Gerardo Claudio melatonin peripheral blood mononuclear leukocytes serotonin visible light 5 hydroxyindoleacetic acid melatonin phytohemagglutinin serotonin thymidine thymidine h 3 unclassified drug article controlled study dna replication dna synthesis human human cell light membrane binding monocyte Base Sequence Cells, Cultured DNA DNA Primers Gene Expression Human In Vitro Indoles Leukocytes, Mononuclear Light Melatonin Molecular Sequence Data Opsin Serotonin Support, Non-U.S. Gov't Overnight light exposure of cultured human peripheral blood mononuclear leukocytes [PBML], significantly increased basal [3H]thymidine incorporation and upon stimulation with phytohemagglutinin [PHA]. Melatonin (10-9 to 10-5 M) enhanced the light-induced increase of [3H]thymidine incorporation, while serotonin (10-9 to 10-7 M) stimulated [3H]thymidine incorporation in the dark. The wavelengths responsible of this effect were restricted to the blue-green zone of the spectrum. The stimulatory effect of visible light on PHA-induced DNA replication had a circannual rhythm, being maximal during winter. In winter, white light also reduced melatonin and serotonin binding to PBML membranes and switched the PBML indole metabolism towards serotonin and 5-hydroxy-indole-acetic acid [HIAA] synthesis, with a concomitant decrease of melatonin production. © 1995. Fil:Finocchiaro, L.M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Glikin, G.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1995 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v57_n11_p1097_Finocchiaro http://hdl.handle.net/20.500.12110/paper_00243205_v57_n11_p1097_Finocchiaro
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	melatonin peripheral blood mononuclear leukocytes serotonin visible light 5 hydroxyindoleacetic acid melatonin phytohemagglutinin serotonin thymidine thymidine h 3 unclassified drug article controlled study dna replication dna synthesis human human cell light membrane binding monocyte Base Sequence Cells, Cultured DNA DNA Primers Gene Expression Human In Vitro Indoles Leukocytes, Mononuclear Light Melatonin Molecular Sequence Data Opsin Serotonin Support, Non-U.S. Gov't
spellingShingle	melatonin peripheral blood mononuclear leukocytes serotonin visible light 5 hydroxyindoleacetic acid melatonin phytohemagglutinin serotonin thymidine thymidine h 3 unclassified drug article controlled study dna replication dna synthesis human human cell light membrane binding monocyte Base Sequence Cells, Cultured DNA DNA Primers Gene Expression Human In Vitro Indoles Leukocytes, Mononuclear Light Melatonin Molecular Sequence Data Opsin Serotonin Support, Non-U.S. Gov't Finocchiaro, Liliana María Elena Glikin, Gerardo Claudio Sensitivity of human peripheral blood mononuclear leukocytes to visible light
topic_facet	melatonin peripheral blood mononuclear leukocytes serotonin visible light 5 hydroxyindoleacetic acid melatonin phytohemagglutinin serotonin thymidine thymidine h 3 unclassified drug article controlled study dna replication dna synthesis human human cell light membrane binding monocyte Base Sequence Cells, Cultured DNA DNA Primers Gene Expression Human In Vitro Indoles Leukocytes, Mononuclear Light Melatonin Molecular Sequence Data Opsin Serotonin Support, Non-U.S. Gov't
description	Overnight light exposure of cultured human peripheral blood mononuclear leukocytes [PBML], significantly increased basal [3H]thymidine incorporation and upon stimulation with phytohemagglutinin [PHA]. Melatonin (10-9 to 10-5 M) enhanced the light-induced increase of [3H]thymidine incorporation, while serotonin (10-9 to 10-7 M) stimulated [3H]thymidine incorporation in the dark. The wavelengths responsible of this effect were restricted to the blue-green zone of the spectrum. The stimulatory effect of visible light on PHA-induced DNA replication had a circannual rhythm, being maximal during winter. In winter, white light also reduced melatonin and serotonin binding to PBML membranes and switched the PBML indole metabolism towards serotonin and 5-hydroxy-indole-acetic acid [HIAA] synthesis, with a concomitant decrease of melatonin production. © 1995.
author	Finocchiaro, Liliana María Elena Glikin, Gerardo Claudio
author_facet	Finocchiaro, Liliana María Elena Glikin, Gerardo Claudio
author_sort	Finocchiaro, Liliana María Elena
title	Sensitivity of human peripheral blood mononuclear leukocytes to visible light
title_short	Sensitivity of human peripheral blood mononuclear leukocytes to visible light
title_full	Sensitivity of human peripheral blood mononuclear leukocytes to visible light
title_fullStr	Sensitivity of human peripheral blood mononuclear leukocytes to visible light
title_full_unstemmed	Sensitivity of human peripheral blood mononuclear leukocytes to visible light
title_sort	sensitivity of human peripheral blood mononuclear leukocytes to visible light
publishDate	1995
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v57_n11_p1097_Finocchiaro http://hdl.handle.net/20.500.12110/paper_00243205_v57_n11_p1097_Finocchiaro
work_keys_str_mv	AT finocchiarolilianamariaelena sensitivityofhumanperipheralbloodmononuclearleukocytestovisiblelight AT glikingerardoclaudio sensitivityofhumanperipheralbloodmononuclearleukocytestovisiblelight
_version_	1840327648008470528

Sensitivity of human peripheral blood mononuclear leukocytes to visible light

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