3H-noradrenaline metabolism in the isolated epididymal and prostatic portions of the rat vas deferens
The spontaneous 3H-noradrenaline efflux from the isolated epididymal and prostatic portions of the rat vas deferens, was investigated. The spontaneous tritium efflux was higher in the epididymal portion than in the prostatic one from normal animals. Such differences were abolished after castration....
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1981
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v29_n15_p1583_FernandezPardal http://hdl.handle.net/20.500.12110/paper_00243205_v29_n15_p1583_FernandezPardal |
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paper:paper_00243205_v29_n15_p1583_FernandezPardal |
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paper:paper_00243205_v29_n15_p1583_FernandezPardal2023-06-08T14:51:58Z 3H-noradrenaline metabolism in the isolated epididymal and prostatic portions of the rat vas deferens acetylsalicylic acid phenoxybenzamine phentolamine radioisotope 3,4 dihydroxymandelic acid 3,4 dihydroxyphenylethylene glycol 3,4-dihydroxymandelic acid 4 hydroxy 3 methoxyphenylethylene glycol drug derivative mandelic acid derivative noradrenalin animal experiment drug metabolism endocrine system epididymis male genital system metabolism noradrenalin h 3 prostate rat vas deferens animal article castration drug effect epididymis in vitro study male muscle contraction prostate rat strain vas deferens Animal Castration Epididymis In Vitro Male Mandelic Acids Methoxyhydroxyphenylglycol Muscle Contraction Norepinephrine Prostate Rats Rats, Inbred Strains Support, Non-U.S. Gov't Vas Deferens The spontaneous 3H-noradrenaline efflux from the isolated epididymal and prostatic portions of the rat vas deferens, was investigated. The spontaneous tritium efflux was higher in the epididymal portion than in the prostatic one from normal animals. Such differences were abolished after castration. On the other hand, acetylsalicylic acid enhanced the total tritium efflux only in the epididymal portion, whereas phentolamine and phenoxybenzamine increased the total tritium efflux from the two portions of the rat vas deferens in both experimental groups. The prostatic portion released a similar amount of 3H normetanephrine than the apididymal end, whereas other metabolic fractions (3,4-dihydroxyphenylglycol; 3,4-dihydroxymandelic acid and O-methylated deaminated metabolites) were smaller in the prostatic portion in comparison with the epididymal portion from control vas deferens. The results presented in the isolated rat vas deferens suggest the existence of a prostaglandin as well as an alpha adrenoceptive modulation of the spontaneous total tritium efflux. © 1981. 1981 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v29_n15_p1583_FernandezPardal http://hdl.handle.net/20.500.12110/paper_00243205_v29_n15_p1583_FernandezPardal |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
acetylsalicylic acid phenoxybenzamine phentolamine radioisotope 3,4 dihydroxymandelic acid 3,4 dihydroxyphenylethylene glycol 3,4-dihydroxymandelic acid 4 hydroxy 3 methoxyphenylethylene glycol drug derivative mandelic acid derivative noradrenalin animal experiment drug metabolism endocrine system epididymis male genital system metabolism noradrenalin h 3 prostate rat vas deferens animal article castration drug effect epididymis in vitro study male muscle contraction prostate rat strain vas deferens Animal Castration Epididymis In Vitro Male Mandelic Acids Methoxyhydroxyphenylglycol Muscle Contraction Norepinephrine Prostate Rats Rats, Inbred Strains Support, Non-U.S. Gov't Vas Deferens |
| spellingShingle |
acetylsalicylic acid phenoxybenzamine phentolamine radioisotope 3,4 dihydroxymandelic acid 3,4 dihydroxyphenylethylene glycol 3,4-dihydroxymandelic acid 4 hydroxy 3 methoxyphenylethylene glycol drug derivative mandelic acid derivative noradrenalin animal experiment drug metabolism endocrine system epididymis male genital system metabolism noradrenalin h 3 prostate rat vas deferens animal article castration drug effect epididymis in vitro study male muscle contraction prostate rat strain vas deferens Animal Castration Epididymis In Vitro Male Mandelic Acids Methoxyhydroxyphenylglycol Muscle Contraction Norepinephrine Prostate Rats Rats, Inbred Strains Support, Non-U.S. Gov't Vas Deferens 3H-noradrenaline metabolism in the isolated epididymal and prostatic portions of the rat vas deferens |
| topic_facet |
acetylsalicylic acid phenoxybenzamine phentolamine radioisotope 3,4 dihydroxymandelic acid 3,4 dihydroxyphenylethylene glycol 3,4-dihydroxymandelic acid 4 hydroxy 3 methoxyphenylethylene glycol drug derivative mandelic acid derivative noradrenalin animal experiment drug metabolism endocrine system epididymis male genital system metabolism noradrenalin h 3 prostate rat vas deferens animal article castration drug effect epididymis in vitro study male muscle contraction prostate rat strain vas deferens Animal Castration Epididymis In Vitro Male Mandelic Acids Methoxyhydroxyphenylglycol Muscle Contraction Norepinephrine Prostate Rats Rats, Inbred Strains Support, Non-U.S. Gov't Vas Deferens |
| description |
The spontaneous 3H-noradrenaline efflux from the isolated epididymal and prostatic portions of the rat vas deferens, was investigated. The spontaneous tritium efflux was higher in the epididymal portion than in the prostatic one from normal animals. Such differences were abolished after castration. On the other hand, acetylsalicylic acid enhanced the total tritium efflux only in the epididymal portion, whereas phentolamine and phenoxybenzamine increased the total tritium efflux from the two portions of the rat vas deferens in both experimental groups. The prostatic portion released a similar amount of 3H normetanephrine than the apididymal end, whereas other metabolic fractions (3,4-dihydroxyphenylglycol; 3,4-dihydroxymandelic acid and O-methylated deaminated metabolites) were smaller in the prostatic portion in comparison with the epididymal portion from control vas deferens. The results presented in the isolated rat vas deferens suggest the existence of a prostaglandin as well as an alpha adrenoceptive modulation of the spontaneous total tritium efflux. © 1981. |
| title |
3H-noradrenaline metabolism in the isolated epididymal and prostatic portions of the rat vas deferens |
| title_short |
3H-noradrenaline metabolism in the isolated epididymal and prostatic portions of the rat vas deferens |
| title_full |
3H-noradrenaline metabolism in the isolated epididymal and prostatic portions of the rat vas deferens |
| title_fullStr |
3H-noradrenaline metabolism in the isolated epididymal and prostatic portions of the rat vas deferens |
| title_full_unstemmed |
3H-noradrenaline metabolism in the isolated epididymal and prostatic portions of the rat vas deferens |
| title_sort |
3h-noradrenaline metabolism in the isolated epididymal and prostatic portions of the rat vas deferens |
| publishDate |
1981 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v29_n15_p1583_FernandezPardal http://hdl.handle.net/20.500.12110/paper_00243205_v29_n15_p1583_FernandezPardal |
| _version_ |
1768545406189305856 |