Aggregation Studies of Lithium Diahlkylamides. The Role of Aggregates in the Carbonylation Reaction

13C NMR spectroscopy and isotopic exchange in carbonylation intermediates have been successfully employed to characterize aggregation of lithium dialkylamides in THF solution. It is shown that lithium (3-oxapentamethylene)amide forms a 1:1 mixed aggregate with morpholine. The aggregate remains even...

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Publicado: 1993
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223263_v58_n7_p1847_Nudelman
http://hdl.handle.net/20.500.12110/paper_00223263_v58_n7_p1847_Nudelman
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_00223263_v58_n7_p1847_Nudelman
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spelling paper:paper_00223263_v58_n7_p1847_Nudelman2023-06-08T14:49:28Z Aggregation Studies of Lithium Diahlkylamides. The Role of Aggregates in the Carbonylation Reaction 13C NMR spectroscopy and isotopic exchange in carbonylation intermediates have been successfully employed to characterize aggregation of lithium dialkylamides in THF solution. It is shown that lithium (3-oxapentamethylene)amide forms a 1:1 mixed aggregate with morpholine. The aggregate remains even in diluted THF solution. Lithium pentamethyleneamide also forms aggregates with piperidine while the less acidic amines do not form mixed aggregates with the corresponding lithium dialkylamide either in the solid state or in THF solution. The product composition in the carbonylation reaction of lithium dialkylamides is highly dependent on their aggregation states, and this phenomenon can be successfully used for synthetic purposes. © 1993, American Chemical Society. All rights reserved. 1993 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223263_v58_n7_p1847_Nudelman http://hdl.handle.net/20.500.12110/paper_00223263_v58_n7_p1847_Nudelman
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
description 13C NMR spectroscopy and isotopic exchange in carbonylation intermediates have been successfully employed to characterize aggregation of lithium dialkylamides in THF solution. It is shown that lithium (3-oxapentamethylene)amide forms a 1:1 mixed aggregate with morpholine. The aggregate remains even in diluted THF solution. Lithium pentamethyleneamide also forms aggregates with piperidine while the less acidic amines do not form mixed aggregates with the corresponding lithium dialkylamide either in the solid state or in THF solution. The product composition in the carbonylation reaction of lithium dialkylamides is highly dependent on their aggregation states, and this phenomenon can be successfully used for synthetic purposes. © 1993, American Chemical Society. All rights reserved.
title Aggregation Studies of Lithium Diahlkylamides. The Role of Aggregates in the Carbonylation Reaction
spellingShingle Aggregation Studies of Lithium Diahlkylamides. The Role of Aggregates in the Carbonylation Reaction
title_short Aggregation Studies of Lithium Diahlkylamides. The Role of Aggregates in the Carbonylation Reaction
title_full Aggregation Studies of Lithium Diahlkylamides. The Role of Aggregates in the Carbonylation Reaction
title_fullStr Aggregation Studies of Lithium Diahlkylamides. The Role of Aggregates in the Carbonylation Reaction
title_full_unstemmed Aggregation Studies of Lithium Diahlkylamides. The Role of Aggregates in the Carbonylation Reaction
title_sort aggregation studies of lithium diahlkylamides. the role of aggregates in the carbonylation reaction
publishDate 1993
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223263_v58_n7_p1847_Nudelman
http://hdl.handle.net/20.500.12110/paper_00223263_v58_n7_p1847_Nudelman
_version_ 1768546102241394688

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