How the stimulus defines the dynamics of vesicle pool recruitment, fusion mode, and vesicle recycling in neuroendocrine cells
The pattern of stimulation defines important characteristics of the secretory process in neurons and neuroendocrine cells, including the pool of secretory vesicles being recruited, the type and amount of transmitters released, the mode of membrane retrieval, and the mechanisms associated with vesicl...
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paper:paper_00223042_v_n_p867_Cardenas2023-06-08T14:49:07Z How the stimulus defines the dynamics of vesicle pool recruitment, fusion mode, and vesicle recycling in neuroendocrine cells Marengo, Fernando Diego calcium endocytosis exocytosis immediately releasable pool kiss-and-run secretion actin calcineurin calcium channel calcium ion clathrin dynamin synaptotagmin voltage gated calcium channel calcium signaling cell fusion chromaffin cell endocytosis exocytosis human nerve cell nerve cell membrane steady potential nerve cell stimulation neurosecretion neurosecretory cell neurotransmitter release nonhuman priority journal Review secretory vesicle stimulus response synaptic transmission The pattern of stimulation defines important characteristics of the secretory process in neurons and neuroendocrine cells, including the pool of secretory vesicles being recruited, the type and amount of transmitters released, the mode of membrane retrieval, and the mechanisms associated with vesicle replenishment. This review analyzes the mechanisms that regulate these processes in chromaffin cells, as well as in other neuroendocrine and neuronal models. A common factor in these mechanisms is the spatial and temporal distribution of the Ca2+ signal generated during cell stimulation. For instance, neurosecretory cells and neurons have pools of vesicles with different locations with respect to Ca2+ channels, and those pools are therefore differentially recruited following different patterns of stimulation. In this regard, a brief stimulus will induce the exocytosis of a small pool of vesicles that is highly coupled to voltage-dependent Ca2+ channels, whereas longer or more intense stimulation will provoke a global Ca2+ increase, promoting exocytosis irrespective of vesicle location. The pattern of stimulation, and therefore the characteristics of the Ca2+ signal generated by the stimulus also influence the mode of exocytosis and the type of endocytosis. Indeed, low-frequency stimulation favors kiss-and-run exocytosis and clathrin-independent fast endocytosis, whereas higher frequencies promote full fusion and clathrin-dependent endocytosis. This latter type of endocytosis is accelerated at high-frequency stimulation. Synaptotagmins, calcineurin, dynamin, complexin, and actin remodeling, appear to be involved in the mechanisms that determine the response of these processes to Ca2+. (Figure presented.) In chromaffin cells, a brief stimulus induces the exocytosis of a small pool of vesicles that is highly coupled to voltage-dependent Ca2+ channels (A), whereas longer or high-frequency stimulation provokes a global Ca2+ increase, promoting exocytosis irrespective of vesicle location (B). Furthermore, low-frequency stimulation favors kiss-and-run exocytosis (A), whereas higher frequencies promote full fusion (B). In this review, we analyze the mechanisms by which a given stimulation pattern defines the mode of exocytosis, and recruitment and recycling of neurosecretory vesicles. This article is part of a mini review series on Chromaffin cells (ISCCB Meeting, 2015). © 2016 International Society for Neurochemistry Fil:Marengo, F.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223042_v_n_p867_Cardenas http://hdl.handle.net/20.500.12110/paper_00223042_v_n_p867_Cardenas |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
calcium endocytosis exocytosis immediately releasable pool kiss-and-run secretion actin calcineurin calcium channel calcium ion clathrin dynamin synaptotagmin voltage gated calcium channel calcium signaling cell fusion chromaffin cell endocytosis exocytosis human nerve cell nerve cell membrane steady potential nerve cell stimulation neurosecretion neurosecretory cell neurotransmitter release nonhuman priority journal Review secretory vesicle stimulus response synaptic transmission |
| spellingShingle |
calcium endocytosis exocytosis immediately releasable pool kiss-and-run secretion actin calcineurin calcium channel calcium ion clathrin dynamin synaptotagmin voltage gated calcium channel calcium signaling cell fusion chromaffin cell endocytosis exocytosis human nerve cell nerve cell membrane steady potential nerve cell stimulation neurosecretion neurosecretory cell neurotransmitter release nonhuman priority journal Review secretory vesicle stimulus response synaptic transmission Marengo, Fernando Diego How the stimulus defines the dynamics of vesicle pool recruitment, fusion mode, and vesicle recycling in neuroendocrine cells |
| topic_facet |
calcium endocytosis exocytosis immediately releasable pool kiss-and-run secretion actin calcineurin calcium channel calcium ion clathrin dynamin synaptotagmin voltage gated calcium channel calcium signaling cell fusion chromaffin cell endocytosis exocytosis human nerve cell nerve cell membrane steady potential nerve cell stimulation neurosecretion neurosecretory cell neurotransmitter release nonhuman priority journal Review secretory vesicle stimulus response synaptic transmission |
| description |
The pattern of stimulation defines important characteristics of the secretory process in neurons and neuroendocrine cells, including the pool of secretory vesicles being recruited, the type and amount of transmitters released, the mode of membrane retrieval, and the mechanisms associated with vesicle replenishment. This review analyzes the mechanisms that regulate these processes in chromaffin cells, as well as in other neuroendocrine and neuronal models. A common factor in these mechanisms is the spatial and temporal distribution of the Ca2+ signal generated during cell stimulation. For instance, neurosecretory cells and neurons have pools of vesicles with different locations with respect to Ca2+ channels, and those pools are therefore differentially recruited following different patterns of stimulation. In this regard, a brief stimulus will induce the exocytosis of a small pool of vesicles that is highly coupled to voltage-dependent Ca2+ channels, whereas longer or more intense stimulation will provoke a global Ca2+ increase, promoting exocytosis irrespective of vesicle location. The pattern of stimulation, and therefore the characteristics of the Ca2+ signal generated by the stimulus also influence the mode of exocytosis and the type of endocytosis. Indeed, low-frequency stimulation favors kiss-and-run exocytosis and clathrin-independent fast endocytosis, whereas higher frequencies promote full fusion and clathrin-dependent endocytosis. This latter type of endocytosis is accelerated at high-frequency stimulation. Synaptotagmins, calcineurin, dynamin, complexin, and actin remodeling, appear to be involved in the mechanisms that determine the response of these processes to Ca2+. (Figure presented.) In chromaffin cells, a brief stimulus induces the exocytosis of a small pool of vesicles that is highly coupled to voltage-dependent Ca2+ channels (A), whereas longer or high-frequency stimulation provokes a global Ca2+ increase, promoting exocytosis irrespective of vesicle location (B). Furthermore, low-frequency stimulation favors kiss-and-run exocytosis (A), whereas higher frequencies promote full fusion (B). In this review, we analyze the mechanisms by which a given stimulation pattern defines the mode of exocytosis, and recruitment and recycling of neurosecretory vesicles. This article is part of a mini review series on Chromaffin cells (ISCCB Meeting, 2015). © 2016 International Society for Neurochemistry |
| author |
Marengo, Fernando Diego |
| author_facet |
Marengo, Fernando Diego |
| author_sort |
Marengo, Fernando Diego |
| title |
How the stimulus defines the dynamics of vesicle pool recruitment, fusion mode, and vesicle recycling in neuroendocrine cells |
| title_short |
How the stimulus defines the dynamics of vesicle pool recruitment, fusion mode, and vesicle recycling in neuroendocrine cells |
| title_full |
How the stimulus defines the dynamics of vesicle pool recruitment, fusion mode, and vesicle recycling in neuroendocrine cells |
| title_fullStr |
How the stimulus defines the dynamics of vesicle pool recruitment, fusion mode, and vesicle recycling in neuroendocrine cells |
| title_full_unstemmed |
How the stimulus defines the dynamics of vesicle pool recruitment, fusion mode, and vesicle recycling in neuroendocrine cells |
| title_sort |
how the stimulus defines the dynamics of vesicle pool recruitment, fusion mode, and vesicle recycling in neuroendocrine cells |
| publishDate |
2016 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223042_v_n_p867_Cardenas http://hdl.handle.net/20.500.12110/paper_00223042_v_n_p867_Cardenas |
| work_keys_str_mv |
AT marengofernandodiego howthestimulusdefinesthedynamicsofvesiclepoolrecruitmentfusionmodeandvesiclerecyclinginneuroendocrinecells |
| _version_ |
1768544027798405120 |