N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase path...
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2014
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223042_v129_n1_p60_Baidanoff http://hdl.handle.net/20.500.12110/paper_00223042_v129_n1_p60_Baidanoff |
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paper:paper_00223042_v129_n1_p60_Baidanoff2025-07-30T17:31:08Z N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms Doctorovich, Fabio Ariel Suarez, Sebastian Golombek, Diego Andrés Chiesa, Juan José circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus melatonin melatonin derivative n nitrosomelatonin nitrate nitric oxide nitric oxide synthase nitrite PER1 protein protein c fos unclassified drug adult animal experiment animal model animal tissue article chronobiology circadian rhythm controlled study drug mechanism immunoreactivity in vivo study jet lag light dark cycle locomotion male nonhuman photic synchronization photoperiodicity priority journal suprachiasmatic nucleus Cricetinae Mammalia Murinae circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus Animals Circadian Rhythm Cricetinae Male Melatonin Mesocricetus Motor Activity Nitroso Compounds Photic Stimulation Photoperiod Suprachiasmatic Nucleus Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase pathway. We have employed a novel nitric oxide-donor, N-nitrosomelatonin, to enhance the photic synchronization of circadian rhythms in hamsters. The intraperitoneal administration of this drug before a sub-saturating light pulse at circadian time 18 generated a twofold increase of locomotor rhythm phase-advances, having no effect over saturating light pulses. This potentiation was also obtained even when inhibiting suprachiasmatic nitric oxide synthase activity. However, N-nitrosomelatonin had no effect on light-induced phase delays at circadian time 14. The photic-enhancing effects were correlated with an increased suprachiasmatic immunoreactivity of FBJ murine osteosarcoma viral oncogene and period1. Moreover, in vivo nitric oxide release by N-nitrosomelatonin was verified by measuring nitrate and nitrite levels in suprachiasmatic nuclei homogenates. The compound also accelerated resynchronization to an abrupt 6-h advance in the light:dark cycle (but not resynchronization to a 6-h delay). Here, we demonstrate the chronobiotic properties of N-nitrosomelatonin, emphasizing the importance of nitric oxide-mediated transduction for circadian phase advances. © 2013 International Society for Neurochemistry. Fil:Doctorovich, F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Suárez, S.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Golombek, D.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Chiesa, J.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223042_v129_n1_p60_Baidanoff http://hdl.handle.net/20.500.12110/paper_00223042_v129_n1_p60_Baidanoff |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus melatonin melatonin derivative n nitrosomelatonin nitrate nitric oxide nitric oxide synthase nitrite PER1 protein protein c fos unclassified drug adult animal experiment animal model animal tissue article chronobiology circadian rhythm controlled study drug mechanism immunoreactivity in vivo study jet lag light dark cycle locomotion male nonhuman photic synchronization photoperiodicity priority journal suprachiasmatic nucleus Cricetinae Mammalia Murinae circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus Animals Circadian Rhythm Cricetinae Male Melatonin Mesocricetus Motor Activity Nitroso Compounds Photic Stimulation Photoperiod Suprachiasmatic Nucleus |
| spellingShingle |
circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus melatonin melatonin derivative n nitrosomelatonin nitrate nitric oxide nitric oxide synthase nitrite PER1 protein protein c fos unclassified drug adult animal experiment animal model animal tissue article chronobiology circadian rhythm controlled study drug mechanism immunoreactivity in vivo study jet lag light dark cycle locomotion male nonhuman photic synchronization photoperiodicity priority journal suprachiasmatic nucleus Cricetinae Mammalia Murinae circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus Animals Circadian Rhythm Cricetinae Male Melatonin Mesocricetus Motor Activity Nitroso Compounds Photic Stimulation Photoperiod Suprachiasmatic Nucleus Doctorovich, Fabio Ariel Suarez, Sebastian Golombek, Diego Andrés Chiesa, Juan José N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms |
| topic_facet |
circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus melatonin melatonin derivative n nitrosomelatonin nitrate nitric oxide nitric oxide synthase nitrite PER1 protein protein c fos unclassified drug adult animal experiment animal model animal tissue article chronobiology circadian rhythm controlled study drug mechanism immunoreactivity in vivo study jet lag light dark cycle locomotion male nonhuman photic synchronization photoperiodicity priority journal suprachiasmatic nucleus Cricetinae Mammalia Murinae circadian jet lag N-nitrosomelatonin nitric oxide suprachiasmatic nucleus Animals Circadian Rhythm Cricetinae Male Melatonin Mesocricetus Motor Activity Nitroso Compounds Photic Stimulation Photoperiod Suprachiasmatic Nucleus |
| description |
Most physiological processes in mammals are synchronized to the daily light:dark cycle by a circadian clock located in the hypothalamic suprachiasmatic nucleus. Signal transduction of light-induced phase advances of the clock is mediated through a neuronal nitric oxide synthase-guanilyl cyclase pathway. We have employed a novel nitric oxide-donor, N-nitrosomelatonin, to enhance the photic synchronization of circadian rhythms in hamsters. The intraperitoneal administration of this drug before a sub-saturating light pulse at circadian time 18 generated a twofold increase of locomotor rhythm phase-advances, having no effect over saturating light pulses. This potentiation was also obtained even when inhibiting suprachiasmatic nitric oxide synthase activity. However, N-nitrosomelatonin had no effect on light-induced phase delays at circadian time 14. The photic-enhancing effects were correlated with an increased suprachiasmatic immunoreactivity of FBJ murine osteosarcoma viral oncogene and period1. Moreover, in vivo nitric oxide release by N-nitrosomelatonin was verified by measuring nitrate and nitrite levels in suprachiasmatic nuclei homogenates. The compound also accelerated resynchronization to an abrupt 6-h advance in the light:dark cycle (but not resynchronization to a 6-h delay). Here, we demonstrate the chronobiotic properties of N-nitrosomelatonin, emphasizing the importance of nitric oxide-mediated transduction for circadian phase advances. © 2013 International Society for Neurochemistry. |
| author |
Doctorovich, Fabio Ariel Suarez, Sebastian Golombek, Diego Andrés Chiesa, Juan José |
| author_facet |
Doctorovich, Fabio Ariel Suarez, Sebastian Golombek, Diego Andrés Chiesa, Juan José |
| author_sort |
Doctorovich, Fabio Ariel |
| title |
N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms |
| title_short |
N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms |
| title_full |
N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms |
| title_fullStr |
N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms |
| title_full_unstemmed |
N-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms |
| title_sort |
n-nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms |
| publishDate |
2014 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223042_v129_n1_p60_Baidanoff http://hdl.handle.net/20.500.12110/paper_00223042_v129_n1_p60_Baidanoff |
| work_keys_str_mv |
AT doctorovichfabioariel nnitrosomelatoninenhancesphoticsynchronizationofmammaliancircadianrhythms AT suarezsebastian nnitrosomelatoninenhancesphoticsynchronizationofmammaliancircadianrhythms AT golombekdiegoandres nnitrosomelatoninenhancesphoticsynchronizationofmammaliancircadianrhythms AT chiesajuanjose nnitrosomelatoninenhancesphoticsynchronizationofmammaliancircadianrhythms |
| _version_ |
1840323573618573312 |