The RNA Response to DNA Damage

Multicellular organisms must ensure genome integrity to prevent accumulation of mutations, cell death, and cancer. The DNA damage response (DDR) is a complex network that senses, signals, and executes multiple programs including DNA repair, cell cycle arrest, senescence, and apoptosis. This entails...

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Autores principales:	Giono, Luciana Eugenia, Muñoz, Manuel Javier, Kornblihtt, Alberto Rodolfo
Publicado:	2016
Materias:	alternative splicing DNA damage response ncRNAs p53 RNA processing caspase 2 caspase 8 caspase 9 cyclin D1 cyclin E DNA elastin Fas antigen fibronectin growth arrest and DNA damage inducible protein 45 heterogeneous nuclear ribonucleoprotein heterogeneous nuclear ribonucleoprotein C heterogeneous nuclear ribonucleoprotein K long untranslated RNA messenger RNA microRNA protein Bax protein bcl x protein p21 protein p53 RNA RNA polymerase II survivin untranslated RNA alternative RNA splicing DNA damage DNA transcription excision repair genetic transcription human nonhuman priority journal protein localization Review RNA degradation RNA metabolism RNA translation transcription elongation translation regulation DNA repair gene expression genetics DNA Damage DNA Repair Gene Expression Humans
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00222836_v428_n12_p2636_Giono http://hdl.handle.net/20.500.12110/paper_00222836_v428_n12_p2636_Giono
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	paper:paper_00222836_v428_n12_p2636_Giono2025-07-30T17:30:49Z The RNA Response to DNA Damage Giono, Luciana Eugenia Muñoz, Manuel Javier Kornblihtt, Alberto Rodolfo alternative splicing DNA damage response ncRNAs p53 RNA processing caspase 2 caspase 8 caspase 9 cyclin D1 cyclin E DNA elastin Fas antigen fibronectin growth arrest and DNA damage inducible protein 45 heterogeneous nuclear ribonucleoprotein heterogeneous nuclear ribonucleoprotein C heterogeneous nuclear ribonucleoprotein K long untranslated RNA messenger RNA microRNA protein Bax protein bcl x protein p21 protein p53 RNA RNA polymerase II survivin untranslated RNA RNA alternative RNA splicing DNA damage DNA transcription excision repair genetic transcription human nonhuman priority journal protein localization Review RNA degradation RNA metabolism RNA processing RNA translation transcription elongation translation regulation DNA damage DNA repair gene expression genetics DNA Damage DNA Repair Gene Expression Humans RNA Multicellular organisms must ensure genome integrity to prevent accumulation of mutations, cell death, and cancer. The DNA damage response (DDR) is a complex network that senses, signals, and executes multiple programs including DNA repair, cell cycle arrest, senescence, and apoptosis. This entails regulation of a variety of cellular processes: DNA replication and transcription, RNA processing, mRNA translation and turnover, and post-translational modification, degradation, and relocalization of proteins. Accumulated evidence over the past decades has shown that RNAs and RNA metabolism are both regulators and regulated actors of the DDR. This review aims to present a comprehensive overview of the current knowledge on the many interactions between the DNA damage and RNA fields. © 2016 Elsevier Ltd. Fil:Giono, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Muñoz, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Kornblihtt, A.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00222836_v428_n12_p2636_Giono http://hdl.handle.net/20.500.12110/paper_00222836_v428_n12_p2636_Giono
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	alternative splicing DNA damage response ncRNAs p53 RNA processing caspase 2 caspase 8 caspase 9 cyclin D1 cyclin E DNA elastin Fas antigen fibronectin growth arrest and DNA damage inducible protein 45 heterogeneous nuclear ribonucleoprotein heterogeneous nuclear ribonucleoprotein C heterogeneous nuclear ribonucleoprotein K long untranslated RNA messenger RNA microRNA protein Bax protein bcl x protein p21 protein p53 RNA RNA polymerase II survivin untranslated RNA RNA alternative RNA splicing DNA damage DNA transcription excision repair genetic transcription human nonhuman priority journal protein localization Review RNA degradation RNA metabolism RNA processing RNA translation transcription elongation translation regulation DNA damage DNA repair gene expression genetics DNA Damage DNA Repair Gene Expression Humans RNA
spellingShingle	alternative splicing DNA damage response ncRNAs p53 RNA processing caspase 2 caspase 8 caspase 9 cyclin D1 cyclin E DNA elastin Fas antigen fibronectin growth arrest and DNA damage inducible protein 45 heterogeneous nuclear ribonucleoprotein heterogeneous nuclear ribonucleoprotein C heterogeneous nuclear ribonucleoprotein K long untranslated RNA messenger RNA microRNA protein Bax protein bcl x protein p21 protein p53 RNA RNA polymerase II survivin untranslated RNA RNA alternative RNA splicing DNA damage DNA transcription excision repair genetic transcription human nonhuman priority journal protein localization Review RNA degradation RNA metabolism RNA processing RNA translation transcription elongation translation regulation DNA damage DNA repair gene expression genetics DNA Damage DNA Repair Gene Expression Humans RNA Giono, Luciana Eugenia Muñoz, Manuel Javier Kornblihtt, Alberto Rodolfo The RNA Response to DNA Damage
topic_facet	alternative splicing DNA damage response ncRNAs p53 RNA processing caspase 2 caspase 8 caspase 9 cyclin D1 cyclin E DNA elastin Fas antigen fibronectin growth arrest and DNA damage inducible protein 45 heterogeneous nuclear ribonucleoprotein heterogeneous nuclear ribonucleoprotein C heterogeneous nuclear ribonucleoprotein K long untranslated RNA messenger RNA microRNA protein Bax protein bcl x protein p21 protein p53 RNA RNA polymerase II survivin untranslated RNA RNA alternative RNA splicing DNA damage DNA transcription excision repair genetic transcription human nonhuman priority journal protein localization Review RNA degradation RNA metabolism RNA processing RNA translation transcription elongation translation regulation DNA damage DNA repair gene expression genetics DNA Damage DNA Repair Gene Expression Humans RNA
description	Multicellular organisms must ensure genome integrity to prevent accumulation of mutations, cell death, and cancer. The DNA damage response (DDR) is a complex network that senses, signals, and executes multiple programs including DNA repair, cell cycle arrest, senescence, and apoptosis. This entails regulation of a variety of cellular processes: DNA replication and transcription, RNA processing, mRNA translation and turnover, and post-translational modification, degradation, and relocalization of proteins. Accumulated evidence over the past decades has shown that RNAs and RNA metabolism are both regulators and regulated actors of the DDR. This review aims to present a comprehensive overview of the current knowledge on the many interactions between the DNA damage and RNA fields. © 2016 Elsevier Ltd.
author	Giono, Luciana Eugenia Muñoz, Manuel Javier Kornblihtt, Alberto Rodolfo
author_facet	Giono, Luciana Eugenia Muñoz, Manuel Javier Kornblihtt, Alberto Rodolfo
author_sort	Giono, Luciana Eugenia
title	The RNA Response to DNA Damage
title_short	The RNA Response to DNA Damage
title_full	The RNA Response to DNA Damage
title_fullStr	The RNA Response to DNA Damage
title_full_unstemmed	The RNA Response to DNA Damage
title_sort	rna response to dna damage
publishDate	2016
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00222836_v428_n12_p2636_Giono http://hdl.handle.net/20.500.12110/paper_00222836_v428_n12_p2636_Giono
work_keys_str_mv	AT gionolucianaeugenia thernaresponsetodnadamage AT munozmanueljavier thernaresponsetodnadamage AT kornblihttalbertorodolfo thernaresponsetodnadamage AT gionolucianaeugenia rnaresponsetodnadamage AT munozmanueljavier rnaresponsetodnadamage AT kornblihttalbertorodolfo rnaresponsetodnadamage
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The RNA Response to DNA Damage

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