Microwave-Assisted Synthesis of Pyrrolo[2,1-b]thiazoles Linked to a Carbohydrate Moiety

Mostrar todas las versiones(2)

Herein, we describe the synthesis of pyrrolo[2,1-b]thiazoles substituted on C-2 or C-5 with a protected carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and the N-alkylation step was assisted by microwave irradiation. The new products were completely...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Barradas, José Sebastián, Errea, María Inés, Sepúlveda, Claudia Soledad, Damonte, Elsa Beatriz, D'Accorso, Norma Beatriz
Publicado: 2013
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0022152X_v_n_p_Barradas
http://hdl.handle.net/20.500.12110/paper_0022152X_v_n_p_Barradas
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_0022152X_v_n_p_Barradas
record_format dspace
spelling paper:paper_0022152X_v_n_p_Barradas2023-06-08T14:46:51Z Microwave-Assisted Synthesis of Pyrrolo[2,1-b]thiazoles Linked to a Carbohydrate Moiety Barradas, José Sebastián Errea, María Inés Sepúlveda, Claudia Soledad Damonte, Elsa Beatriz D'Accorso, Norma Beatriz Herein, we describe the synthesis of pyrrolo[2,1-b]thiazoles substituted on C-2 or C-5 with a protected carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus of the methylated derivates was also evaluated. © 2013 HeteroCorporation. Fil:Barradas, J.S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Errea, M.I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sepúlveda, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Damonte, E.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:D'Accorso, N.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0022152X_v_n_p_Barradas http://hdl.handle.net/20.500.12110/paper_0022152X_v_n_p_Barradas
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
description Herein, we describe the synthesis of pyrrolo[2,1-b]thiazoles substituted on C-2 or C-5 with a protected carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus of the methylated derivates was also evaluated. © 2013 HeteroCorporation.
author Barradas, José Sebastián
Errea, María Inés
Sepúlveda, Claudia Soledad
Damonte, Elsa Beatriz
D'Accorso, Norma Beatriz
spellingShingle Barradas, José Sebastián
Errea, María Inés
Sepúlveda, Claudia Soledad
Damonte, Elsa Beatriz
D'Accorso, Norma Beatriz
Microwave-Assisted Synthesis of Pyrrolo[2,1-b]thiazoles Linked to a Carbohydrate Moiety
author_facet Barradas, José Sebastián
Errea, María Inés
Sepúlveda, Claudia Soledad
Damonte, Elsa Beatriz
D'Accorso, Norma Beatriz
author_sort Barradas, José Sebastián
title Microwave-Assisted Synthesis of Pyrrolo[2,1-b]thiazoles Linked to a Carbohydrate Moiety
title_short Microwave-Assisted Synthesis of Pyrrolo[2,1-b]thiazoles Linked to a Carbohydrate Moiety
title_full Microwave-Assisted Synthesis of Pyrrolo[2,1-b]thiazoles Linked to a Carbohydrate Moiety
title_fullStr Microwave-Assisted Synthesis of Pyrrolo[2,1-b]thiazoles Linked to a Carbohydrate Moiety
title_full_unstemmed Microwave-Assisted Synthesis of Pyrrolo[2,1-b]thiazoles Linked to a Carbohydrate Moiety
title_sort microwave-assisted synthesis of pyrrolo[2,1-b]thiazoles linked to a carbohydrate moiety
publishDate 2013
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0022152X_v_n_p_Barradas
http://hdl.handle.net/20.500.12110/paper_0022152X_v_n_p_Barradas
work_keys_str_mv AT barradasjosesebastian microwaveassistedsynthesisofpyrrolo21bthiazoleslinkedtoacarbohydratemoiety
AT erreamariaines microwaveassistedsynthesisofpyrrolo21bthiazoleslinkedtoacarbohydratemoiety
AT sepulvedaclaudiasoledad microwaveassistedsynthesisofpyrrolo21bthiazoleslinkedtoacarbohydratemoiety
AT damonteelsabeatriz microwaveassistedsynthesisofpyrrolo21bthiazoleslinkedtoacarbohydratemoiety
AT daccorsonormabeatriz microwaveassistedsynthesisofpyrrolo21bthiazoleslinkedtoacarbohydratemoiety
_version_ 1768542536449654784

Ejemplares similares