Kinetoplastids: Related protozoan pathogens, different diseases
Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their genetic relatedness and underlined difference...
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2008
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219738_v118_n4_p1301_Stuart http://hdl.handle.net/20.500.12110/paper_00219738_v118_n4_p1301_Stuart |
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paper:paper_00219738_v118_n4_p1301_Stuart2023-06-08T14:44:50Z Kinetoplastids: Related protozoan pathogens, different diseases amphotericin B lipid complex benznidazole eflornithine insecticide interleukin 1 interleukin 10 interleukin 12 interleukin 18 Leishmania vaccine meglumine antimonate melarsoprol miltefosine nifurtimox paromomycin pentamidine isethionate stibogluconate sodium suramin toll like receptor 4 toll like receptor 7 toll like receptor 8 toll like receptor 9 transforming growth factor beta Chagas disease continuous infusion flagellate gene sequence genome human infection control Leishmania Leishmania braziliensis Leishmania donovani Leishmania infantum Leishmania major Leishmania mexicana Leishmania tropica leishmaniasis nonhuman patient compliance priority journal protozoon review teratogenicity Trypanosoma Trypanosoma brucei Trypanosoma cruzi Trypanosoma gambiense unspecified side effect Animals Antiprotozoal Agents Genetic Vectors Genome, Protozoan Humans Kinetoplastida Mastigophora Infections Protozoan Vaccines Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their genetic relatedness and underlined differences in the diseases that they cause. As we discuss in this Review, steady progress using a combination of molecular, genetic, immunologic, and clinical approaches has substantially increased understanding of these pathogens and important aspects of the diseases that they cause. Consequently, the paths for developing additional measures to control these "neglected diseases" are becoming increasingly clear, and we believe that the opportunities for developing the drugs, diagnostics, vaccines, and other tools necessary to expand the armamentarium to combat these diseases have never been better. 2008 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219738_v118_n4_p1301_Stuart http://hdl.handle.net/20.500.12110/paper_00219738_v118_n4_p1301_Stuart |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
amphotericin B lipid complex benznidazole eflornithine insecticide interleukin 1 interleukin 10 interleukin 12 interleukin 18 Leishmania vaccine meglumine antimonate melarsoprol miltefosine nifurtimox paromomycin pentamidine isethionate stibogluconate sodium suramin toll like receptor 4 toll like receptor 7 toll like receptor 8 toll like receptor 9 transforming growth factor beta Chagas disease continuous infusion flagellate gene sequence genome human infection control Leishmania Leishmania braziliensis Leishmania donovani Leishmania infantum Leishmania major Leishmania mexicana Leishmania tropica leishmaniasis nonhuman patient compliance priority journal protozoon review teratogenicity Trypanosoma Trypanosoma brucei Trypanosoma cruzi Trypanosoma gambiense unspecified side effect Animals Antiprotozoal Agents Genetic Vectors Genome, Protozoan Humans Kinetoplastida Mastigophora Infections Protozoan Vaccines |
| spellingShingle |
amphotericin B lipid complex benznidazole eflornithine insecticide interleukin 1 interleukin 10 interleukin 12 interleukin 18 Leishmania vaccine meglumine antimonate melarsoprol miltefosine nifurtimox paromomycin pentamidine isethionate stibogluconate sodium suramin toll like receptor 4 toll like receptor 7 toll like receptor 8 toll like receptor 9 transforming growth factor beta Chagas disease continuous infusion flagellate gene sequence genome human infection control Leishmania Leishmania braziliensis Leishmania donovani Leishmania infantum Leishmania major Leishmania mexicana Leishmania tropica leishmaniasis nonhuman patient compliance priority journal protozoon review teratogenicity Trypanosoma Trypanosoma brucei Trypanosoma cruzi Trypanosoma gambiense unspecified side effect Animals Antiprotozoal Agents Genetic Vectors Genome, Protozoan Humans Kinetoplastida Mastigophora Infections Protozoan Vaccines Kinetoplastids: Related protozoan pathogens, different diseases |
| topic_facet |
amphotericin B lipid complex benznidazole eflornithine insecticide interleukin 1 interleukin 10 interleukin 12 interleukin 18 Leishmania vaccine meglumine antimonate melarsoprol miltefosine nifurtimox paromomycin pentamidine isethionate stibogluconate sodium suramin toll like receptor 4 toll like receptor 7 toll like receptor 8 toll like receptor 9 transforming growth factor beta Chagas disease continuous infusion flagellate gene sequence genome human infection control Leishmania Leishmania braziliensis Leishmania donovani Leishmania infantum Leishmania major Leishmania mexicana Leishmania tropica leishmaniasis nonhuman patient compliance priority journal protozoon review teratogenicity Trypanosoma Trypanosoma brucei Trypanosoma cruzi Trypanosoma gambiense unspecified side effect Animals Antiprotozoal Agents Genetic Vectors Genome, Protozoan Humans Kinetoplastida Mastigophora Infections Protozoan Vaccines |
| description |
Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their genetic relatedness and underlined differences in the diseases that they cause. As we discuss in this Review, steady progress using a combination of molecular, genetic, immunologic, and clinical approaches has substantially increased understanding of these pathogens and important aspects of the diseases that they cause. Consequently, the paths for developing additional measures to control these "neglected diseases" are becoming increasingly clear, and we believe that the opportunities for developing the drugs, diagnostics, vaccines, and other tools necessary to expand the armamentarium to combat these diseases have never been better. |
| title |
Kinetoplastids: Related protozoan pathogens, different diseases |
| title_short |
Kinetoplastids: Related protozoan pathogens, different diseases |
| title_full |
Kinetoplastids: Related protozoan pathogens, different diseases |
| title_fullStr |
Kinetoplastids: Related protozoan pathogens, different diseases |
| title_full_unstemmed |
Kinetoplastids: Related protozoan pathogens, different diseases |
| title_sort |
kinetoplastids: related protozoan pathogens, different diseases |
| publishDate |
2008 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00219738_v118_n4_p1301_Stuart http://hdl.handle.net/20.500.12110/paper_00219738_v118_n4_p1301_Stuart |
| _version_ |
1768542490871201792 |