Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase
1. 1. Basal levels and allyl-isopropylacetamide (AIA) or veronal induced levels of δ-aminolevulinate synthetase (ALA-S), cytochrome P-450 (cyt P-450) and cytochrome oxidase were determined in tumor (T) and liver of both normal mice (NM) and T bearing mice (TBM). 2. 2. Basal levels of ALA-S were near...
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1990
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v22_n9_p1005_Navone http://hdl.handle.net/20.500.12110/paper_0020711X_v22_n9_p1005_Navone |
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paper:paper_0020711X_v22_n9_p1005_Navone2023-06-08T14:41:12Z Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase Batlle, Alcira María del Carmen 5 aminolevulinate synthase allylisopropylacetamide barbital cytochrome c oxidase cytochrome p450 animal cell article breast cancer liver mouse nonhuman 5-Aminolevulinate Synthetase Allylisopropylacetamide Animal Barbital Cytochrome P-450 Enzyme System Cytochrome-c Oxidase Enzyme Induction Heme Liver Male Mammary Neoplasms, Experimental Mice Mice, Inbred BALB C Support, Non-U.S. Gov't Animalia 1. 1. Basal levels and allyl-isopropylacetamide (AIA) or veronal induced levels of δ-aminolevulinate synthetase (ALA-S), cytochrome P-450 (cyt P-450) and cytochrome oxidase were determined in tumor (T) and liver of both normal mice (NM) and T bearing mice (TBM). 2. 2. Basal levels of ALA-S were nearly the same in either source. The amount of cyt P-450 was lower in TBM liver than in NM liver, and no detectable in T. While the basal activity of cytochrome oxidase in TBM liver and T were higher than those of NM liver. 3. 3. In AIA intoxicated animals there was a lower induction of ALA-S in liver of TBM than in NM liver. There was no induction in T ALA-S. The loss of cyt P-450 was less in TBM liver when compared with NM liver. 4. 4. The induction level of cyt P-450 after veronal administration was nearly the same in liver of both TBM and NM. 5. 5. We conclude that lower induction of liver ALA-S activity in TBM liver is due to correspondingly lower drug metabolism ability of TBM liver. Otherwise our results suggest that the control mechanism operating in T and probably in its original tissue are different from those described for normal liver. © 1990. Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1990 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v22_n9_p1005_Navone http://hdl.handle.net/20.500.12110/paper_0020711X_v22_n9_p1005_Navone |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
5 aminolevulinate synthase allylisopropylacetamide barbital cytochrome c oxidase cytochrome p450 animal cell article breast cancer liver mouse nonhuman 5-Aminolevulinate Synthetase Allylisopropylacetamide Animal Barbital Cytochrome P-450 Enzyme System Cytochrome-c Oxidase Enzyme Induction Heme Liver Male Mammary Neoplasms, Experimental Mice Mice, Inbred BALB C Support, Non-U.S. Gov't Animalia |
| spellingShingle |
5 aminolevulinate synthase allylisopropylacetamide barbital cytochrome c oxidase cytochrome p450 animal cell article breast cancer liver mouse nonhuman 5-Aminolevulinate Synthetase Allylisopropylacetamide Animal Barbital Cytochrome P-450 Enzyme System Cytochrome-c Oxidase Enzyme Induction Heme Liver Male Mammary Neoplasms, Experimental Mice Mice, Inbred BALB C Support, Non-U.S. Gov't Animalia Batlle, Alcira María del Carmen Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase |
| topic_facet |
5 aminolevulinate synthase allylisopropylacetamide barbital cytochrome c oxidase cytochrome p450 animal cell article breast cancer liver mouse nonhuman 5-Aminolevulinate Synthetase Allylisopropylacetamide Animal Barbital Cytochrome P-450 Enzyme System Cytochrome-c Oxidase Enzyme Induction Heme Liver Male Mammary Neoplasms, Experimental Mice Mice, Inbred BALB C Support, Non-U.S. Gov't Animalia |
| description |
1. 1. Basal levels and allyl-isopropylacetamide (AIA) or veronal induced levels of δ-aminolevulinate synthetase (ALA-S), cytochrome P-450 (cyt P-450) and cytochrome oxidase were determined in tumor (T) and liver of both normal mice (NM) and T bearing mice (TBM). 2. 2. Basal levels of ALA-S were nearly the same in either source. The amount of cyt P-450 was lower in TBM liver than in NM liver, and no detectable in T. While the basal activity of cytochrome oxidase in TBM liver and T were higher than those of NM liver. 3. 3. In AIA intoxicated animals there was a lower induction of ALA-S in liver of TBM than in NM liver. There was no induction in T ALA-S. The loss of cyt P-450 was less in TBM liver when compared with NM liver. 4. 4. The induction level of cyt P-450 after veronal administration was nearly the same in liver of both TBM and NM. 5. 5. We conclude that lower induction of liver ALA-S activity in TBM liver is due to correspondingly lower drug metabolism ability of TBM liver. Otherwise our results suggest that the control mechanism operating in T and probably in its original tissue are different from those described for normal liver. © 1990. |
| author |
Batlle, Alcira María del Carmen |
| author_facet |
Batlle, Alcira María del Carmen |
| author_sort |
Batlle, Alcira María del Carmen |
| title |
Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase |
| title_short |
Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase |
| title_full |
Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase |
| title_fullStr |
Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase |
| title_full_unstemmed |
Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-I. Effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase |
| title_sort |
heme regulation in mouse mammary carcinoma and liver of tumor bearing mice-i. effect of allyl-isopropylacetamide and veronal on δ -aminolevulinate synthetase, cytochrome p-450 and cytochrome oxidase |
| publishDate |
1990 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v22_n9_p1005_Navone http://hdl.handle.net/20.500.12110/paper_0020711X_v22_n9_p1005_Navone |
| work_keys_str_mv |
AT batllealciramariadelcarmen hemeregulationinmousemammarycarcinomaandliveroftumorbearingmiceieffectofallylisopropylacetamideandveronalondaminolevulinatesynthetasecytochromep450andcytochromeoxidase |
| _version_ |
1768545678085062656 |