Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I

1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2....

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Autores principales:	Ríos de Molina, María del Carmen, Wainstok de Calmanovici, Rosa, San Martín de Viale, Leonor Carmen
Publicado:	1987
Materias:	hexachlorobenzene uroporphyrinogen decarboxylase animal model liver nonhuman porphyria rat Animal Carboxy-Lyases Chlorobenzenes Female Hexachlorobenzene Liver Porphyria Porphyrinogens Rats Rats, Inbred Strains Support, Non-U.S. Gov't Uroporphyrinogen Decarboxylase Uroporphyrinogens
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v19_n4_p365_RiosdeMolinadel http://hdl.handle.net/20.500.12110/paper_0020711X_v19_n4_p365_RiosdeMolinadel
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_0020711X_v19_n4_p365_RiosdeMolinadel
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spelling	paper:paper_0020711X_v19_n4_p365_RiosdeMolinadel2023-06-08T14:41:08Z Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I Ríos de Molina, María del Carmen Wainstok de Calmanovici, Rosa San Martín de Viale, Leonor Carmen hexachlorobenzene uroporphyrinogen decarboxylase animal model liver nonhuman porphyria rat Animal Carboxy-Lyases Chlorobenzenes Female Hexachlorobenzene Liver Porphyria Porphyrinogens Rats Rats, Inbred Strains Support, Non-U.S. Gov't Uroporphyrinogen Decarboxylase Uroporphyrinogens 1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2. The same enzyme is involved in the Urogen decarboxylation of both isomeric series I and III and catalyses the four steps in both cases. HCB affects all of them. 3. 3. HCB blocks the four steps of Urogen III decarboxylation to the same degree, as a function of intoxication time. 4. 4. HCB leads, in general, to an increase in the efficiency (Km/Vmax) of the porphyric system. These data can be interpreted as a reaction of the organism to overcome the enzymatic blockade. © 1987. Fil:Rios de Molina del, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Wainstok de Calmanovici, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:San Martin de Viale, L.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1987 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v19_n4_p365_RiosdeMolinadel http://hdl.handle.net/20.500.12110/paper_0020711X_v19_n4_p365_RiosdeMolinadel
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	hexachlorobenzene uroporphyrinogen decarboxylase animal model liver nonhuman porphyria rat Animal Carboxy-Lyases Chlorobenzenes Female Hexachlorobenzene Liver Porphyria Porphyrinogens Rats Rats, Inbred Strains Support, Non-U.S. Gov't Uroporphyrinogen Decarboxylase Uroporphyrinogens
spellingShingle	hexachlorobenzene uroporphyrinogen decarboxylase animal model liver nonhuman porphyria rat Animal Carboxy-Lyases Chlorobenzenes Female Hexachlorobenzene Liver Porphyria Porphyrinogens Rats Rats, Inbred Strains Support, Non-U.S. Gov't Uroporphyrinogen Decarboxylase Uroporphyrinogens Ríos de Molina, María del Carmen Wainstok de Calmanovici, Rosa San Martín de Viale, Leonor Carmen Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
topic_facet	hexachlorobenzene uroporphyrinogen decarboxylase animal model liver nonhuman porphyria rat Animal Carboxy-Lyases Chlorobenzenes Female Hexachlorobenzene Liver Porphyria Porphyrinogens Rats Rats, Inbred Strains Support, Non-U.S. Gov't Uroporphyrinogen Decarboxylase Uroporphyrinogens
description	1. 1. The present work studies the action of hexachlorobenzene (HCB) on the decarboxylation of uroporphyrinogen (Urogen) I and III and also on the decarboxylation of intermediate porphyrinogens of series III under different conditions using liver of normal and porphyric rats as enzyme source. 2. 2. The same enzyme is involved in the Urogen decarboxylation of both isomeric series I and III and catalyses the four steps in both cases. HCB affects all of them. 3. 3. HCB blocks the four steps of Urogen III decarboxylation to the same degree, as a function of intoxication time. 4. 4. HCB leads, in general, to an increase in the efficiency (Km/Vmax) of the porphyric system. These data can be interpreted as a reaction of the organism to overcome the enzymatic blockade. © 1987.
author	Ríos de Molina, María del Carmen Wainstok de Calmanovici, Rosa San Martín de Viale, Leonor Carmen
author_facet	Ríos de Molina, María del Carmen Wainstok de Calmanovici, Rosa San Martín de Viale, Leonor Carmen
author_sort	Ríos de Molina, María del Carmen
title	Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
title_short	Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
title_full	Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
title_fullStr	Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
title_full_unstemmed	Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I
title_sort	liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. studies with intermediate porphyrinogens of series iii and with uroporphyrinogen i
publishDate	1987
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v19_n4_p365_RiosdeMolinadel http://hdl.handle.net/20.500.12110/paper_0020711X_v19_n4_p365_RiosdeMolinadel
work_keys_str_mv	AT riosdemolinamariadelcarmen liverporphyrinogencarboxylyaseinhexachlorobenzeneporphyricratsstudieswithintermediateporphyrinogensofseriesiiiandwithuroporphyrinogeni AT wainstokdecalmanovicirosa liverporphyrinogencarboxylyaseinhexachlorobenzeneporphyricratsstudieswithintermediateporphyrinogensofseriesiiiandwithuroporphyrinogeni AT sanmartindevialeleonorcarmen liverporphyrinogencarboxylyaseinhexachlorobenzeneporphyricratsstudieswithintermediateporphyrinogensofseriesiiiandwithuroporphyrinogeni
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Liver porphyrinogen carboxylyase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I

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