Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy
1. 1. Five patients with chronic lead intoxication were treated with S-adenosyl-l-methionine (12 mg/kg body weight, daily), given intravenously, over a period of 22 days. 2. 2. A significant recovery of erythrocytic ALA-D was observed in all cases, after therapy. 3. 3. Blood lead content significant...
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1985
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v17_n5_p625_Paredes http://hdl.handle.net/20.500.12110/paper_0020711X_v17_n5_p625_Paredes |
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paper:paper_0020711X_v17_n5_p625_Paredes2025-07-30T17:23:33Z Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy Paredes, Sergio Raúl Batlle, Alcira María del Carmen glutathione lead porphobilinogen synthase s adenosylmethionine chelation clinical article drug therapy human intoxication lead poisoning therapy Adult Child Child, Preschool Erythrocytes Female gamma-Glutamyltransferase Glutathione Human Hydroxymethylbilane Synthase Lead Lead Poisoning Male Porphobilinogen Synthase Porphyrins S-Adenosylmethionine Support, Non-U.S. Gov't Time Factors 1. 1. Five patients with chronic lead intoxication were treated with S-adenosyl-l-methionine (12 mg/kg body weight, daily), given intravenously, over a period of 22 days. 2. 2. A significant recovery of erythrocytic ALA-D was observed in all cases, after therapy. 3. 3. Blood lead content significantly pathologic at the beginning of SAM administration, rapidly decreased within 24-48 h of initiating treatment, reaching nearly control values at the end of the trial. 4. 4. A good correlation between recovery of ALA-D activity and decreased concentration of lead in RBC was found. 5. 5. GSH content in blood was diminished in lead poisoned patients, increasing to normal levels after SAM administration. 6. 6. Other biochemical parameters such as Deaminase activity in RBC, ALA, PBG, porphyrins and lead in urine and serum γ-GT were measured, showing no important deviations from control values before, during or after treatment. 7. 7. Both biochemical and clinical improvement was observed, indicating that SAM therapy is beneficial in the treatment of lead intoxication. No untoward signs were observed. 8. 8. The mechanism of action of SAM is not yet clear; however, a chelating effect could be excluded, and very likely its action can be attributed to glutathione availability. © 1985. Fil:Paredes, S.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Del C. Batlle, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1985 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v17_n5_p625_Paredes http://hdl.handle.net/20.500.12110/paper_0020711X_v17_n5_p625_Paredes |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
glutathione lead porphobilinogen synthase s adenosylmethionine chelation clinical article drug therapy human intoxication lead poisoning therapy Adult Child Child, Preschool Erythrocytes Female gamma-Glutamyltransferase Glutathione Human Hydroxymethylbilane Synthase Lead Lead Poisoning Male Porphobilinogen Synthase Porphyrins S-Adenosylmethionine Support, Non-U.S. Gov't Time Factors |
| spellingShingle |
glutathione lead porphobilinogen synthase s adenosylmethionine chelation clinical article drug therapy human intoxication lead poisoning therapy Adult Child Child, Preschool Erythrocytes Female gamma-Glutamyltransferase Glutathione Human Hydroxymethylbilane Synthase Lead Lead Poisoning Male Porphobilinogen Synthase Porphyrins S-Adenosylmethionine Support, Non-U.S. Gov't Time Factors Paredes, Sergio Raúl Batlle, Alcira María del Carmen Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy |
| topic_facet |
glutathione lead porphobilinogen synthase s adenosylmethionine chelation clinical article drug therapy human intoxication lead poisoning therapy Adult Child Child, Preschool Erythrocytes Female gamma-Glutamyltransferase Glutathione Human Hydroxymethylbilane Synthase Lead Lead Poisoning Male Porphobilinogen Synthase Porphyrins S-Adenosylmethionine Support, Non-U.S. Gov't Time Factors |
| description |
1. 1. Five patients with chronic lead intoxication were treated with S-adenosyl-l-methionine (12 mg/kg body weight, daily), given intravenously, over a period of 22 days. 2. 2. A significant recovery of erythrocytic ALA-D was observed in all cases, after therapy. 3. 3. Blood lead content significantly pathologic at the beginning of SAM administration, rapidly decreased within 24-48 h of initiating treatment, reaching nearly control values at the end of the trial. 4. 4. A good correlation between recovery of ALA-D activity and decreased concentration of lead in RBC was found. 5. 5. GSH content in blood was diminished in lead poisoned patients, increasing to normal levels after SAM administration. 6. 6. Other biochemical parameters such as Deaminase activity in RBC, ALA, PBG, porphyrins and lead in urine and serum γ-GT were measured, showing no important deviations from control values before, during or after treatment. 7. 7. Both biochemical and clinical improvement was observed, indicating that SAM therapy is beneficial in the treatment of lead intoxication. No untoward signs were observed. 8. 8. The mechanism of action of SAM is not yet clear; however, a chelating effect could be excluded, and very likely its action can be attributed to glutathione availability. © 1985. |
| author |
Paredes, Sergio Raúl Batlle, Alcira María del Carmen |
| author_facet |
Paredes, Sergio Raúl Batlle, Alcira María del Carmen |
| author_sort |
Paredes, Sergio Raúl |
| title |
Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy |
| title_short |
Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy |
| title_full |
Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy |
| title_fullStr |
Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy |
| title_full_unstemmed |
Beneficial effect of S-adenosyl-l-methionine in lead intoxication. Another approach to clinical therapy |
| title_sort |
beneficial effect of s-adenosyl-l-methionine in lead intoxication. another approach to clinical therapy |
| publishDate |
1985 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0020711X_v17_n5_p625_Paredes http://hdl.handle.net/20.500.12110/paper_0020711X_v17_n5_p625_Paredes |
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| _version_ |
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