Neuroendocrine changes in female rats born from streptozotocin-diabetic mothers
In adult female rats born from Streptozotocin-diabetic mothers, blood glucose measured under basal conditions or 30 min later after glucose administration was similar to controls; however at 180 min 50% of offspring from diabetics was moderately hyperglycemic whereas 100% of controls were normoglyce...
Guardado en:
| Publicado: |
1987
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00185043_v19_n11_p545_Foglia http://hdl.handle.net/20.500.12110/paper_00185043_v19_n11_p545_Foglia |
| Aporte de: |
| id |
paper:paper_00185043_v19_n11_p545_Foglia |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_00185043_v19_n11_p545_Foglia2023-06-08T14:39:32Z Neuroendocrine changes in female rats born from streptozotocin-diabetic mothers estradiol luteinizing hormone progesterone receptor steroid receptor central nervous system child endocrine system etiology female genital system hypothalamus nonhuman pregnancy pregnancy diabetes mellitus progeny rat streptozocin diabetes In adult female rats born from Streptozotocin-diabetic mothers, blood glucose measured under basal conditions or 30 min later after glucose administration was similar to controls; however at 180 min 50% of offspring from diabetics was moderately hyperglycemic whereas 100% of controls were normoglycemic. The time of vaginal opening, and after maturity, the number of rats with regular estrous cycles was in the range of controls. After ovariectomy, control rats receiving estradiol showed a sharp increase of serum LH at 4 pm following progesterone treatment at 10 am, while rats born from diabetic mothers failed to modify serum LH. Estradiol receptors in cell nuclei and cytosolic progestin receptors were determined in anterior pituitary, hypothalamus, and preoptic area of rats subjected to a 4-day estradiol treatment. Changes were statistically significant in the hypothalamus only, in that rats born from diabetic mothers showed reduced induction of progestin receptors coupled to increased binding of (3H)-estradiol in cell nuclei. These findings bring support for a hypothalamic defect in rats born from diabetic mothers, the reduction of hypothalamic progestin receptors being reflected in the reduced sensitivity to the positive feedback action of progesterone to release LH. 1987 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00185043_v19_n11_p545_Foglia http://hdl.handle.net/20.500.12110/paper_00185043_v19_n11_p545_Foglia |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
estradiol luteinizing hormone progesterone receptor steroid receptor central nervous system child endocrine system etiology female genital system hypothalamus nonhuman pregnancy pregnancy diabetes mellitus progeny rat streptozocin diabetes |
| spellingShingle |
estradiol luteinizing hormone progesterone receptor steroid receptor central nervous system child endocrine system etiology female genital system hypothalamus nonhuman pregnancy pregnancy diabetes mellitus progeny rat streptozocin diabetes Neuroendocrine changes in female rats born from streptozotocin-diabetic mothers |
| topic_facet |
estradiol luteinizing hormone progesterone receptor steroid receptor central nervous system child endocrine system etiology female genital system hypothalamus nonhuman pregnancy pregnancy diabetes mellitus progeny rat streptozocin diabetes |
| description |
In adult female rats born from Streptozotocin-diabetic mothers, blood glucose measured under basal conditions or 30 min later after glucose administration was similar to controls; however at 180 min 50% of offspring from diabetics was moderately hyperglycemic whereas 100% of controls were normoglycemic. The time of vaginal opening, and after maturity, the number of rats with regular estrous cycles was in the range of controls. After ovariectomy, control rats receiving estradiol showed a sharp increase of serum LH at 4 pm following progesterone treatment at 10 am, while rats born from diabetic mothers failed to modify serum LH. Estradiol receptors in cell nuclei and cytosolic progestin receptors were determined in anterior pituitary, hypothalamus, and preoptic area of rats subjected to a 4-day estradiol treatment. Changes were statistically significant in the hypothalamus only, in that rats born from diabetic mothers showed reduced induction of progestin receptors coupled to increased binding of (3H)-estradiol in cell nuclei. These findings bring support for a hypothalamic defect in rats born from diabetic mothers, the reduction of hypothalamic progestin receptors being reflected in the reduced sensitivity to the positive feedback action of progesterone to release LH. |
| title |
Neuroendocrine changes in female rats born from streptozotocin-diabetic mothers |
| title_short |
Neuroendocrine changes in female rats born from streptozotocin-diabetic mothers |
| title_full |
Neuroendocrine changes in female rats born from streptozotocin-diabetic mothers |
| title_fullStr |
Neuroendocrine changes in female rats born from streptozotocin-diabetic mothers |
| title_full_unstemmed |
Neuroendocrine changes in female rats born from streptozotocin-diabetic mothers |
| title_sort |
neuroendocrine changes in female rats born from streptozotocin-diabetic mothers |
| publishDate |
1987 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00185043_v19_n11_p545_Foglia http://hdl.handle.net/20.500.12110/paper_00185043_v19_n11_p545_Foglia |
| _version_ |
1768542674455887872 |