Quantitative Trait Loci Affecting Starvation Resistance in Drosophila melanogaster
The ability to withstand periods of scarce food resources is an important fitness trait. Starvation resistance is a quantitative trait controlled by multiple interacting genes and exhibits considerable genetic variation in natural populations. This genetic variation could be maintained in the face o...
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2004
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00166731_v166_n4_p1807_Harbison http://hdl.handle.net/20.500.12110/paper_00166731_v166_n4_p1807_Harbison |
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paper:paper_00166731_v166_n4_p1807_Harbison2023-06-08T14:38:41Z Quantitative Trait Loci Affecting Starvation Resistance in Drosophila melanogaster article Drosophila melanogaster female fitness gene insertion gene interaction genetic analysis genetic selection genetic variability hypothesis insect genetics male nonhuman oocyte development phenotype priority journal quantitative trait locus reproduction starvation survival wild type Analysis of Variance Animals Crosses, Genetic DNA Transposable Elements Drosophila melanogaster Genes, Insect Genetic Complementation Test Mutation Quantitative Trait Loci Starvation Variation (Genetics) Arachnida Drosophila melanogaster Hexapoda Insecta insertion sequences Melanogaster The ability to withstand periods of scarce food resources is an important fitness trait. Starvation resistance is a quantitative trait controlled by multiple interacting genes and exhibits considerable genetic variation in natural populations. This genetic variation could be maintained in the face of strong selection due to a trade-off in resource allocation between reproductive activity and individual survival. Knowledge of the genes affecting starvation tolerance and the subset of genes that affect variation in starvation resistance in natural populations would enable us to evaluate this hypothesis from a quantitative genetic perspective. We screened 933 co-isogenic P-element insertion lines to identify candidate genes affecting starvation tolerance. A total of 383 P-element insertions induced highly significant and often sex-specific mutational variance in starvation resistance. We also used deficiency complementation mapping followed by complementation to mutations to identify 12 genes contributing to variation in starvation resistance between two wild-type strains. The genes we identified are involved in oogenesis, metabolism, and feeding behaviors, indicating a possible link to reproduction and survival. However, we also found genes with cell fate specification and cell proliferation phenotypes, which implies that resource allocation during development and at the cellular level may also influence the phenotypic response to starvation. 2004 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00166731_v166_n4_p1807_Harbison http://hdl.handle.net/20.500.12110/paper_00166731_v166_n4_p1807_Harbison |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
article Drosophila melanogaster female fitness gene insertion gene interaction genetic analysis genetic selection genetic variability hypothesis insect genetics male nonhuman oocyte development phenotype priority journal quantitative trait locus reproduction starvation survival wild type Analysis of Variance Animals Crosses, Genetic DNA Transposable Elements Drosophila melanogaster Genes, Insect Genetic Complementation Test Mutation Quantitative Trait Loci Starvation Variation (Genetics) Arachnida Drosophila melanogaster Hexapoda Insecta insertion sequences Melanogaster |
| spellingShingle |
article Drosophila melanogaster female fitness gene insertion gene interaction genetic analysis genetic selection genetic variability hypothesis insect genetics male nonhuman oocyte development phenotype priority journal quantitative trait locus reproduction starvation survival wild type Analysis of Variance Animals Crosses, Genetic DNA Transposable Elements Drosophila melanogaster Genes, Insect Genetic Complementation Test Mutation Quantitative Trait Loci Starvation Variation (Genetics) Arachnida Drosophila melanogaster Hexapoda Insecta insertion sequences Melanogaster Quantitative Trait Loci Affecting Starvation Resistance in Drosophila melanogaster |
| topic_facet |
article Drosophila melanogaster female fitness gene insertion gene interaction genetic analysis genetic selection genetic variability hypothesis insect genetics male nonhuman oocyte development phenotype priority journal quantitative trait locus reproduction starvation survival wild type Analysis of Variance Animals Crosses, Genetic DNA Transposable Elements Drosophila melanogaster Genes, Insect Genetic Complementation Test Mutation Quantitative Trait Loci Starvation Variation (Genetics) Arachnida Drosophila melanogaster Hexapoda Insecta insertion sequences Melanogaster |
| description |
The ability to withstand periods of scarce food resources is an important fitness trait. Starvation resistance is a quantitative trait controlled by multiple interacting genes and exhibits considerable genetic variation in natural populations. This genetic variation could be maintained in the face of strong selection due to a trade-off in resource allocation between reproductive activity and individual survival. Knowledge of the genes affecting starvation tolerance and the subset of genes that affect variation in starvation resistance in natural populations would enable us to evaluate this hypothesis from a quantitative genetic perspective. We screened 933 co-isogenic P-element insertion lines to identify candidate genes affecting starvation tolerance. A total of 383 P-element insertions induced highly significant and often sex-specific mutational variance in starvation resistance. We also used deficiency complementation mapping followed by complementation to mutations to identify 12 genes contributing to variation in starvation resistance between two wild-type strains. The genes we identified are involved in oogenesis, metabolism, and feeding behaviors, indicating a possible link to reproduction and survival. However, we also found genes with cell fate specification and cell proliferation phenotypes, which implies that resource allocation during development and at the cellular level may also influence the phenotypic response to starvation. |
| title |
Quantitative Trait Loci Affecting Starvation Resistance in Drosophila melanogaster |
| title_short |
Quantitative Trait Loci Affecting Starvation Resistance in Drosophila melanogaster |
| title_full |
Quantitative Trait Loci Affecting Starvation Resistance in Drosophila melanogaster |
| title_fullStr |
Quantitative Trait Loci Affecting Starvation Resistance in Drosophila melanogaster |
| title_full_unstemmed |
Quantitative Trait Loci Affecting Starvation Resistance in Drosophila melanogaster |
| title_sort |
quantitative trait loci affecting starvation resistance in drosophila melanogaster |
| publishDate |
2004 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00166731_v166_n4_p1807_Harbison http://hdl.handle.net/20.500.12110/paper_00166731_v166_n4_p1807_Harbison |
| _version_ |
1768546190091091968 |