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spelling paper:paper_00145793_v589_n19_p2763_DeRossi2023-06-08T14:37:44Z Asymmetries in kinesin-2 and cytoplasmic dynein contributions to melanosome transport De Rossi, Maria Emilia Sued, Mariela Rodríguez, Daniela Andrea Bruno, Luciana Levi, Valeria Intracellular transport Molecular motors Single particle tracking Xenopus laevis melanophores cytoplasmic dynein kinesin 2 molecular motor cytoplasmic dynein kinesin Xenopus protein animal cell Article cell aggregation cell culture cell organelle cell transport elasticity mathematical model melanophore melanosome microtubule nonhuman priority journal Xenopus laevis animal melanosome metabolism transport at the cellular level Animals Biological Transport Cytoplasmic Dyneins Kinesin Melanosomes Xenopus laevis Xenopus Proteins The mechanisms involved in bidirectional transport along microtubules remain largely unknown. We explored the collective action of kinesin-2 and dynein motors during transport of melanosomes in Xenopus laevis melanophores. These motors are attached to organelles through accessory proteins establishing a complex molecular linker. We determined both the stiffness of this linker and the organelles speed and observed that these parameters depended on the organelle size and cargo direction. Our results suggest that melanosome transport is driven by two dissimilar teams: whereas dynein motors compete with kinesin-2 affecting the properties of plus-end directed organelles, kinesin-2 does not seem to play a similar role during minus-end transport. © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Fil:De Rossi, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Sued, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rodríguez, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bruno, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Levi, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v589_n19_p2763_DeRossi http://hdl.handle.net/20.500.12110/paper_00145793_v589_n19_p2763_DeRossi
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Intracellular transport
Molecular motors
Single particle tracking
Xenopus laevis melanophores
cytoplasmic dynein
kinesin 2
molecular motor
cytoplasmic dynein
kinesin
Xenopus protein
animal cell
Article
cell aggregation
cell culture
cell organelle
cell transport
elasticity
mathematical model
melanophore
melanosome
microtubule
nonhuman
priority journal
Xenopus laevis
animal
melanosome
metabolism
transport at the cellular level
Animals
Biological Transport
Cytoplasmic Dyneins
Kinesin
Melanosomes
Xenopus laevis
Xenopus Proteins
spellingShingle Intracellular transport
Molecular motors
Single particle tracking
Xenopus laevis melanophores
cytoplasmic dynein
kinesin 2
molecular motor
cytoplasmic dynein
kinesin
Xenopus protein
animal cell
Article
cell aggregation
cell culture
cell organelle
cell transport
elasticity
mathematical model
melanophore
melanosome
microtubule
nonhuman
priority journal
Xenopus laevis
animal
melanosome
metabolism
transport at the cellular level
Animals
Biological Transport
Cytoplasmic Dyneins
Kinesin
Melanosomes
Xenopus laevis
Xenopus Proteins
De Rossi, Maria Emilia
Sued, Mariela
Rodríguez, Daniela Andrea
Bruno, Luciana
Levi, Valeria
Asymmetries in kinesin-2 and cytoplasmic dynein contributions to melanosome transport
topic_facet Intracellular transport
Molecular motors
Single particle tracking
Xenopus laevis melanophores
cytoplasmic dynein
kinesin 2
molecular motor
cytoplasmic dynein
kinesin
Xenopus protein
animal cell
Article
cell aggregation
cell culture
cell organelle
cell transport
elasticity
mathematical model
melanophore
melanosome
microtubule
nonhuman
priority journal
Xenopus laevis
animal
melanosome
metabolism
transport at the cellular level
Animals
Biological Transport
Cytoplasmic Dyneins
Kinesin
Melanosomes
Xenopus laevis
Xenopus Proteins
description The mechanisms involved in bidirectional transport along microtubules remain largely unknown. We explored the collective action of kinesin-2 and dynein motors during transport of melanosomes in Xenopus laevis melanophores. These motors are attached to organelles through accessory proteins establishing a complex molecular linker. We determined both the stiffness of this linker and the organelles speed and observed that these parameters depended on the organelle size and cargo direction. Our results suggest that melanosome transport is driven by two dissimilar teams: whereas dynein motors compete with kinesin-2 affecting the properties of plus-end directed organelles, kinesin-2 does not seem to play a similar role during minus-end transport. © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
author De Rossi, Maria Emilia
Sued, Mariela
Rodríguez, Daniela Andrea
Bruno, Luciana
Levi, Valeria
author_facet De Rossi, Maria Emilia
Sued, Mariela
Rodríguez, Daniela Andrea
Bruno, Luciana
Levi, Valeria
author_sort De Rossi, Maria Emilia
title Asymmetries in kinesin-2 and cytoplasmic dynein contributions to melanosome transport
title_short Asymmetries in kinesin-2 and cytoplasmic dynein contributions to melanosome transport
title_full Asymmetries in kinesin-2 and cytoplasmic dynein contributions to melanosome transport
title_fullStr Asymmetries in kinesin-2 and cytoplasmic dynein contributions to melanosome transport
title_full_unstemmed Asymmetries in kinesin-2 and cytoplasmic dynein contributions to melanosome transport
title_sort asymmetries in kinesin-2 and cytoplasmic dynein contributions to melanosome transport
publishDate 2015
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v589_n19_p2763_DeRossi
http://hdl.handle.net/20.500.12110/paper_00145793_v589_n19_p2763_DeRossi
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