Assessment of colour vision in epileptic patients exposed to single-drug therapy
Diplopia, blurred vision and colour disturbances are well-known side effects associated with anti-epileptic drugs (AEDs). Farnsworth-Munsell 100-hue colour test (F-100) is an accepted and sensitive tool to detect changes in colour perception. To determine the impact of AEDs upon colour vision, we ev...
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1999
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00143022_v41_n4_p201_Lopez http://hdl.handle.net/20.500.12110/paper_00143022_v41_n4_p201_Lopez |
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paper:paper_00143022_v41_n4_p201_Lopez2023-06-08T14:36:56Z Assessment of colour vision in epileptic patients exposed to single-drug therapy Colour discrimination Epileptic patients Farnsworth-Munsell 100-hue test anticonvulsive agent carbamazepine phenytoin valproic acid adolescent adult aged article clinical article color vision defect controlled study epilepsy female filter human male priority journal vision test Adolescent Adult Aged Anticonvulsants Carbamazepine Color Perception Color Vision Defects Diplopia Epilepsy, Complex Partial Female Humans Male Middle Aged Phenytoin Severity of Illness Index Single-Blind Method Valproic Acid Diplopia, blurred vision and colour disturbances are well-known side effects associated with anti-epileptic drugs (AEDs). Farnsworth-Munsell 100-hue colour test (F-100) is an accepted and sensitive tool to detect changes in colour perception. To determine the impact of AEDs upon colour vision, we evaluated 37 consecutive patients with complex partial seizures exposed to monotherapy with phenytoin (PHT, carbamazepine (CBZ) or valproic acid (VPA). All had normal IQ and no congenital disturbances in colour vision or ocular diseases. Twenty normal controls were used for statistical analysis. Thirteen patients were exposed to PHT, 12 to CBZ and 12 to VPA. Visual colour perception was impaired in 30/37 (82%) of the study group. The most significant abnormality was detected in the blue-yellow axis in 10/13 patients exposed to PHT (p < 0.02) and in 8/12 treated with CBZ (p < 0.009). In 8/12 patients taking VPA, no significant abnormality was observed (p < 0.06). None of the studied patients complained of colour vision disturbances. Our findings strongly support the negative effect of AEDs upon colour vision discrimination, most likely due to changes at the retinal processing level. F-100 proved to be very useful to assess early toxicity due to AEDs. 1999 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00143022_v41_n4_p201_Lopez http://hdl.handle.net/20.500.12110/paper_00143022_v41_n4_p201_Lopez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Colour discrimination Epileptic patients Farnsworth-Munsell 100-hue test anticonvulsive agent carbamazepine phenytoin valproic acid adolescent adult aged article clinical article color vision defect controlled study epilepsy female filter human male priority journal vision test Adolescent Adult Aged Anticonvulsants Carbamazepine Color Perception Color Vision Defects Diplopia Epilepsy, Complex Partial Female Humans Male Middle Aged Phenytoin Severity of Illness Index Single-Blind Method Valproic Acid |
| spellingShingle |
Colour discrimination Epileptic patients Farnsworth-Munsell 100-hue test anticonvulsive agent carbamazepine phenytoin valproic acid adolescent adult aged article clinical article color vision defect controlled study epilepsy female filter human male priority journal vision test Adolescent Adult Aged Anticonvulsants Carbamazepine Color Perception Color Vision Defects Diplopia Epilepsy, Complex Partial Female Humans Male Middle Aged Phenytoin Severity of Illness Index Single-Blind Method Valproic Acid Assessment of colour vision in epileptic patients exposed to single-drug therapy |
| topic_facet |
Colour discrimination Epileptic patients Farnsworth-Munsell 100-hue test anticonvulsive agent carbamazepine phenytoin valproic acid adolescent adult aged article clinical article color vision defect controlled study epilepsy female filter human male priority journal vision test Adolescent Adult Aged Anticonvulsants Carbamazepine Color Perception Color Vision Defects Diplopia Epilepsy, Complex Partial Female Humans Male Middle Aged Phenytoin Severity of Illness Index Single-Blind Method Valproic Acid |
| description |
Diplopia, blurred vision and colour disturbances are well-known side effects associated with anti-epileptic drugs (AEDs). Farnsworth-Munsell 100-hue colour test (F-100) is an accepted and sensitive tool to detect changes in colour perception. To determine the impact of AEDs upon colour vision, we evaluated 37 consecutive patients with complex partial seizures exposed to monotherapy with phenytoin (PHT, carbamazepine (CBZ) or valproic acid (VPA). All had normal IQ and no congenital disturbances in colour vision or ocular diseases. Twenty normal controls were used for statistical analysis. Thirteen patients were exposed to PHT, 12 to CBZ and 12 to VPA. Visual colour perception was impaired in 30/37 (82%) of the study group. The most significant abnormality was detected in the blue-yellow axis in 10/13 patients exposed to PHT (p < 0.02) and in 8/12 treated with CBZ (p < 0.009). In 8/12 patients taking VPA, no significant abnormality was observed (p < 0.06). None of the studied patients complained of colour vision disturbances. Our findings strongly support the negative effect of AEDs upon colour vision discrimination, most likely due to changes at the retinal processing level. F-100 proved to be very useful to assess early toxicity due to AEDs. |
| title |
Assessment of colour vision in epileptic patients exposed to single-drug therapy |
| title_short |
Assessment of colour vision in epileptic patients exposed to single-drug therapy |
| title_full |
Assessment of colour vision in epileptic patients exposed to single-drug therapy |
| title_fullStr |
Assessment of colour vision in epileptic patients exposed to single-drug therapy |
| title_full_unstemmed |
Assessment of colour vision in epileptic patients exposed to single-drug therapy |
| title_sort |
assessment of colour vision in epileptic patients exposed to single-drug therapy |
| publishDate |
1999 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00143022_v41_n4_p201_Lopez http://hdl.handle.net/20.500.12110/paper_00143022_v41_n4_p201_Lopez |
| _version_ |
1768546568012562432 |