Benzodiazepine receptor sites in bovine pineal

[3H]Flunitrazepam (FNZP) binds to a single class of high affinity binding sites in bovine pineal membranes (KD 2.8 nM). FNZP binding increased by 25% after exposure to γ-aminobutyric acid and exhibits a high degree of specificity for drugs acting on the central type of benzodiazepine receptor. High...

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Publicado:	1982
Materias:	Benzodiazepine binding Pineal gland β-Carboline binding 4 aminobutyric acid 4' chlorodiazepam benzodiazepine benzodiazepine receptor chlordiazepoxide clonazepam flumazenil flunitrazepam radioisotope animal cell beta carboline 3 carboxylic acid ethyl ester h 3 cattle cell membrane central nervous system drug receptor binding endocrine system flunitrazepam h 3 nonhuman pharmacokinetics pineal body Animal Cattle Flunitrazepam gamma-Aminobutyric Acid In Vitro Kinetics Membranes Pineal Gland Receptors, Cell Surface Receptors, GABA-A Support, Non-U.S. Gov't
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v86_n2_p287_Lowenstein http://hdl.handle.net/20.500.12110/paper_00142999_v86_n2_p287_Lowenstein
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00142999_v86_n2_p287_Lowenstein
record_format	dspace
spelling	paper:paper_00142999_v86_n2_p287_Lowenstein2023-06-08T14:36:56Z Benzodiazepine receptor sites in bovine pineal Benzodiazepine binding Pineal gland β-Carboline binding 4 aminobutyric acid 4' chlorodiazepam benzodiazepine benzodiazepine receptor chlordiazepoxide clonazepam flumazenil flunitrazepam radioisotope animal cell beta carboline 3 carboxylic acid ethyl ester h 3 cattle cell membrane central nervous system drug receptor binding endocrine system flunitrazepam h 3 nonhuman pharmacokinetics pineal body Animal Cattle Flunitrazepam gamma-Aminobutyric Acid In Vitro Kinetics Membranes Pineal Gland Receptors, Cell Surface Receptors, GABA-A Support, Non-U.S. Gov't [3H]Flunitrazepam (FNZP) binds to a single class of high affinity binding sites in bovine pineal membranes (KD 2.8 nM). FNZP binding increased by 25% after exposure to γ-aminobutyric acid and exhibits a high degree of specificity for drugs acting on the central type of benzodiazepine receptor. High affinity binding of [3H]ethyl-3-carboline ester to pineal membranes has a KD 0.8 nM and about 60% of the maximal number of FNZP binding sites. © 1983. 1982 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v86_n2_p287_Lowenstein http://hdl.handle.net/20.500.12110/paper_00142999_v86_n2_p287_Lowenstein
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Benzodiazepine binding Pineal gland β-Carboline binding 4 aminobutyric acid 4' chlorodiazepam benzodiazepine benzodiazepine receptor chlordiazepoxide clonazepam flumazenil flunitrazepam radioisotope animal cell beta carboline 3 carboxylic acid ethyl ester h 3 cattle cell membrane central nervous system drug receptor binding endocrine system flunitrazepam h 3 nonhuman pharmacokinetics pineal body Animal Cattle Flunitrazepam gamma-Aminobutyric Acid In Vitro Kinetics Membranes Pineal Gland Receptors, Cell Surface Receptors, GABA-A Support, Non-U.S. Gov't
spellingShingle	Benzodiazepine binding Pineal gland β-Carboline binding 4 aminobutyric acid 4' chlorodiazepam benzodiazepine benzodiazepine receptor chlordiazepoxide clonazepam flumazenil flunitrazepam radioisotope animal cell beta carboline 3 carboxylic acid ethyl ester h 3 cattle cell membrane central nervous system drug receptor binding endocrine system flunitrazepam h 3 nonhuman pharmacokinetics pineal body Animal Cattle Flunitrazepam gamma-Aminobutyric Acid In Vitro Kinetics Membranes Pineal Gland Receptors, Cell Surface Receptors, GABA-A Support, Non-U.S. Gov't Benzodiazepine receptor sites in bovine pineal
topic_facet	Benzodiazepine binding Pineal gland β-Carboline binding 4 aminobutyric acid 4' chlorodiazepam benzodiazepine benzodiazepine receptor chlordiazepoxide clonazepam flumazenil flunitrazepam radioisotope animal cell beta carboline 3 carboxylic acid ethyl ester h 3 cattle cell membrane central nervous system drug receptor binding endocrine system flunitrazepam h 3 nonhuman pharmacokinetics pineal body Animal Cattle Flunitrazepam gamma-Aminobutyric Acid In Vitro Kinetics Membranes Pineal Gland Receptors, Cell Surface Receptors, GABA-A Support, Non-U.S. Gov't
description	[3H]Flunitrazepam (FNZP) binds to a single class of high affinity binding sites in bovine pineal membranes (KD 2.8 nM). FNZP binding increased by 25% after exposure to γ-aminobutyric acid and exhibits a high degree of specificity for drugs acting on the central type of benzodiazepine receptor. High affinity binding of [3H]ethyl-3-carboline ester to pineal membranes has a KD 0.8 nM and about 60% of the maximal number of FNZP binding sites. © 1983.
title	Benzodiazepine receptor sites in bovine pineal
title_short	Benzodiazepine receptor sites in bovine pineal
title_full	Benzodiazepine receptor sites in bovine pineal
title_fullStr	Benzodiazepine receptor sites in bovine pineal
title_full_unstemmed	Benzodiazepine receptor sites in bovine pineal
title_sort	benzodiazepine receptor sites in bovine pineal
publishDate	1982
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v86_n2_p287_Lowenstein http://hdl.handle.net/20.500.12110/paper_00142999_v86_n2_p287_Lowenstein
_version_	1768546142797168640

Benzodiazepine receptor sites in bovine pineal

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